In:
Artificial Organs, Wiley, Vol. 46, No. 8 ( 2022-08), p. 1522-1532
Abstract:
Thermography is a noninvasive technology to detect low temperatures in poorly circulated areas. In ex vivo lung perfusion (EVLP), lungs are rewarmed to body temperature during the initial 1 h. Currently, the effect of graft thermal changes during the rewarming phase on pulmonary function is unknown. In this study, we evaluated the correlation of lung surface temperature with physiological parameters, wet/dry ratio, and transplant suitability in Lund‐type EVLP. Methods Fifteen pigs were divided into three groups: control group (no warm ischemia) or donation after circulatory death groups with 60 or 90 min of warm ischemia ( n = 5, each). Thermal images of the lower lobes were continuously collected from the bottom of an organ chamber using infrared thermography throughout EVLP. Results At 8 min, lung surface temperatures of nonsuitable cases were significantly lower than in suitable cases (25.1 ± 0.6 vs. 27.8 ± 1.2°C, p 〈 0.001), while there was no difference in lung surface temperatures between the two groups at 0–4 min and 12–120 min. There was a significant negative correlation between lung surface temperatures at 8 min and wet/dry ratio at 2 h in the lower lobes ( R = −0.769, p 〈 0.001, cutoff = 26°C, area under the curve = 1.0). A lung surface temperature of 〈 26°C was significantly correlated with poor pulmonary function and transplant nonsuitability. Conclusion A lung surface temperature of ≥26°C at 8 min is a good early predictor of transplant suitability in cellular EVLP and might be applicable in clinical EVLP.
Type of Medium:
Online Resource
ISSN:
0160-564X
,
1525-1594
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2003825-2
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