In:
ChemPhysChem, Wiley, Vol. 17, No. 23 ( 2016-12-05), p. 3916-3922
Abstract:
Five novel surfactants were prepared by modifying the three hydroxy groups of sodium cholate with triethylene glycol chains endcapped with an amide ( SC‐C 1 , SC‐ n C 4 , and SC‐ n C 5 ) or a carbamoyl group ( SC‐O n C 4 and SC‐O t C 4 ). The phase behavior of aqueous mixtures of these surfactants with 1,2‐dimyristoyl‐ sn ‐glycero‐3‐phosphatidylcholine (DMPC) was systematically studied by 31 P NMR spectroscopy. The surfactants endcapped with carbamate groups ( SC‐O n C 4 and SC‐O t C 4 ) formed magnetically alignable bicelles over unprecedentedly wide ranges of conditions, in terms of temperature (from 21–23 to 〉 90 °C), lipid/surfactant ratio (from 5 to 8), total lipid content (5–20 wt %), and lipid type [DMPC, 1,2‐dilauroyl‐ sn ‐glycero‐3‐phosphatidylcholine (DLPC), or 1‐palmitoyl‐2‐oleoyl‐ sn ‐glycero‐3‐phosphatidylcholine (POPC)]. In conjunction with appropriate phospholipids, the carbamate‐endcapped surfactants afforded unique bicelles, characterized by exceptional thermal stabilities (from 0 to 〉 90 °C), biomimetic lipid compositions (DMPC/POPC=25:75 to 50:50), and extremely large 2 H quadrupole splittings (up to 71 Hz).
Type of Medium:
Online Resource
ISSN:
1439-4235
,
1439-7641
DOI:
10.1002/cphc.201600897
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2025223-7
detail.hit.zdb_id:
2021755-9
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