In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 144, No. Suppl_1 ( 2021-11-16)
Abstract:
Background: Carotid plaque is a well-known prognostic factor for cardiovascular disease and stroke. However, it is unclear which atherosclerotic risk factors are related to plaque transformation in the non-pharmacological population. Purpose: To examine the atherosclerotic risk factors associated with the progression of carotid plaque according to the severity of atherosclerosis Methods: We investigated 738 male participants without medication who underwent the 1 st and the 2 nd health checkups (mean duration: 2.0±1.6 years). We measured carotid plaque thickness (PT) evaluated by using ultrasonography at three points of the right and left carotid artery. Plaque score (PS) was calculated by summing all the PT. We divided into three groups following previous reports: normal stage, PS 〈 1.1 mm; early stage, 1.1 mm 〈 PS 〈 5.1 mm; advanced stage, PS 〉 5.1 mm. We used the risk factors such as age, body mass index, systolic blood pressure (SBP), fasting blood sugar, low-density lipoprotein cholesterol (LDL-C), smoking habits, and exercise habits for analysis. Results: At 1 st health checkup, 108 participants had already progressed to the advanced stage of carotid plaque, 454 participants had the early stage, and 176 participants had the normal stage. 14% of participants with the early stage at 1 st health checkup had progressed to the advanced stage at 2 nd health checkup, and 42% of participants with the normal stage at 1 st health checkup had progressed the early stage at 2 nd health checkup. In multivariate logistic regression analysis, SBP was an independent risk factor for progression of PS stage from the normal stage at 1 st health checkup to the early stage at 2 nd health checkup (SBP; OR 1.27, CI 1.01-1.60, p 〈 0.05). In addition, LDL-C was an independent risk factor associated with further progression of carotid plaque from the early stage at 1 st health checkup to the advanced stage at 2 nd health checkup (LDL-C; OR 1.10, CI 1.00-1.21, p 〈 0.05). Conclusions: SBP was associated with the carotid plaque progression of early atherosclerosis, while LDL-C was associated with the progression of advanced atherosclerosis. We should be aware of risk factors according to the stage of plaque progression.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.144.suppl_1.12227
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021
detail.hit.zdb_id:
1466401-X
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