In:
Annals of Neurology, Wiley, Vol. 88, No. 5 ( 2020-11), p. 1034-1042
Abstract:
In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on magnetic resonance imaging by their paramagnetic rims, and increasing evidence supports their association with severity of clinical disease. We studied their potential role in differential diagnosis, screening an international multicenter clinical research‐based sample of 438 individuals affected by different neurological conditions (MS, other inflammatory, infectious, and non‐inflammatory conditions). Paramagnetic rim lesions, rare in other neurological conditions (52% of MS vs 7% of non‐MS cases), yielded high specificity (93%) in differentiating MS from non‐MS. Future prospective multicenter studies should validate their role as a diagnostic biomarker. ANN NEUROL 2020;88:1034–1042
Type of Medium:
Online Resource
ISSN:
0364-5134
,
1531-8249
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2037912-2
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