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  • 1
    Online Resource
    Online Resource
    P0378SERUM URIC ACID IS ASSOCIATED WITH PROGNOSIS OF LUPUS NEPHRITIS IN FEMALE BUT NOT IN MALE
    Oxford University Press (OUP) ; 2020
    In:  Nephrology Dialysis Transplantation Vol. 35, No. Supplement_3 ( 2020-06-01)
    Details
    In: Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 35, No. Supplement_3 ( 2020-06-01)
    Abstract: Lupus nephritis (LN) is one of the major complications of systemic lupus erythematosus. Early intervention in lupus nephritis is known to benefit patients' prognosis. Recent studies have found an association between hyperuricemia and lupus nephritis, but the sex-specific role of uric acid in lupus nephritis remains unclear. The purpose of this study is to elucidate the relationship between lupus nephritis and hyperuricemia, and to investigate sex differences. Method We retrospectively analyzed 394 patients who diagnosed with LN by renal biopsy. We assessed the effect of serum uric acid on progression of LN using Kaplan–Meier survival analyses and Cox proportional hazards models. The study’s primary end point was LN progression that was defined as the initiation of dialysis. Results The male had a higher mean of serum uric acid level than female. In the overall patient analysis, every 1 mg / dL increase in baseline uric acid level increased the risk of LN progression by about 16.9%. The serum uric acid level was an independent risk factor for LN progression in female (hazard ratio [HR], 1.177; confidence interval [CI] ,1.024 to 1.353; P & lt;0.001) but not in male (HR, 1.0351; CI, 0.661 to 1.622; P = 0.880). A sensitivity analysis involving serum uric acid tertile generated consistent and robust results. Conclusion The serum uric acid level was an independent risk factor for LN progression in female but no in male.
    Type of Medium: Online Resource
    ISSN: 0931-0509 , 1460-2385
    URL: Article
    DOI: 10.1093/ndt/gfaa142.P0378
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
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  • 2
    Online Resource
    Online Resource
    #5394 PHYSICAL ACTIVITY AND THE RISK OF DEMENTIA IN END-STAGE RENAL DISEASE PATIENTS WITH HEMODIALYSIS: A NATIONWIDE POPULATION-BASED STUDY
    Oxford University Press (OUP) ; 2023
    In:  Nephrology Dialysis Transplantation Vol. 38, No. Supplement_1 ( 2023-06-14)
    Details
    In: Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 38, No. Supplement_1 ( 2023-06-14)
    Abstract: Several studies have reported that dementia has a high prevalence in patients with end-stage renal disease (ESRD) patients. However, the relationship between physical activity and the risk of developing dementia has not been elucidated in ESRD patients with hemodialysis. Method A total 19,877 hemodialysis patients aged ≥ 40 years who underwent health check-ups were identified from the Korean National Health Insurance Service database and were analysed in this study. Individuals with physical activities were defined as meeting following criteria: (i) three or more days/week of vigorous activity of at least 20 min per day or (ii) five or more days/week of moderate-intensity activity of at least 30 min per day. The occurrence of dementia was monitored through the end of 2018 by the ICD-10 codes. Results During the 4.6-year follow-up, 1,755 patients with hemodialysis developed dementia. Physical activity was associated with the lower risk of any dementia (hazard ratio [HR], 0.779, 95% confidence interval (CI), 0.7-0.867) even after adjusting for several confounding factors. Risk of developing dementia was still lower in hemodialysis patients with physical activity when we analyse the risk of Alzheimer's dementia and vascular dementia separately (HR 0.817 and 0.685, respectively). In subgroup analyses, the risk of dementia tended to lower in hemodialysis patients with physical activity than without physical activity in all subgroups. Conclusion Physical activity is associated the lower risk of developing dementia in ESRD patients with hemodialysis.
    Type of Medium: Online Resource
    ISSN: 0931-0509 , 1460-2385
    URL: Article
    DOI: 10.1093/ndt/gfad063c_5394
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    P0376EFFECTS OF HYPERURICEMIA ON THE PROGNOSIS OF IGA NEPHROPATHY AND ITS SEX DIFFERENCE
    Oxford University Press (OUP) ; 2020
    In:  Nephrology Dialysis Transplantation Vol. 35, No. Supplement_3 ( 2020-06-01)
    Details
    In: Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 35, No. Supplement_3 ( 2020-06-01)
    Abstract: Hyperuricemia is a potential risk factor for immunoglobulin A nephropathy (IgAN) progression, but its sex-specific effects on IgAN progression remain unclear. This study aimed to determine the effect of serum uric acid on IgAN progression and whether its effect varied according to sex. Method A total of 4339 patients were retrospectively analyzed at a university medical school. We assessed the effect of serum uric acid on IgAN progression using Kaplan–Meier survival analyses and Cox proportional hazards models. The study’s primary end point was IgAN progression that was defined as a 50% decline in the estimated glomerular filtration rate or the initiation of dialysis. Results On average, the serum uric acid levels were higher in the men than in the women. In the fully adjusted Cox proportional hazards model that considered all subjects, the risk of IgAN progression increased by about 25.6% for every 1 mg/dL increase in the baseline uric acid level. The serum uric acid level was an independent risk factor for IgAN progression in both sexes, but its effect was more pronounced in the women (hazard ratio [HR], 1.383; confidence interval [CI] ,1.263 to 1.514; P & lt;0.001) than in the men (HR, 1.181; CI, 1.097 to 1.272; P & lt;0.001) (Pinteraction & lt;0.001). A sensitivity analysis involving serum uric acid quartiles generated consistent and robust results. Conclusion The serum uric acid level was an independent risk factor for IgAN progression, and its effect was more pronounced among the women compared with that among the men.
    Type of Medium: Online Resource
    ISSN: 0931-0509 , 1460-2385
    URL: Article
    DOI: 10.1093/ndt/gfaa142.P0376
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
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  • 4
    Online Resource
    Online Resource
    3D‐Printed Functional Hydrogel by DNA‐Induced Biomineralization for Accelerated Diabetic Wound Healing
    Wiley ; 2023
    In:  Advanced Science Vol. 10, No. 17 ( 2023-06)
    Details
    In: Advanced Science, Wiley, Vol. 10, No. 17 ( 2023-06)
    Abstract: Chronic wounds in diabetic patients are challenging because their prolonged inflammation makes healing difficult, thus burdening patients, society, and health care systems. Customized dressing materials are needed to effectively treat such wounds that vary in shape and depth. The continuous development of 3D‐printing technology along with artificial intelligence has increased the precision, versatility, and compatibility of various materials, thus providing the considerable potential to meet the abovementioned needs. Herein, functional 3D‐printing inks comprising DNA from salmon sperm and DNA‐induced biosilica inspired by marine sponges, are developed for the machine learning‐based 3D‐printing of wound dressings. The DNA and biomineralized silica are incorporated into hydrogel inks in a fast, facile manner. The 3D‐printed wound dressing thus generates provided appropriate porosity, characterized by effective exudate and blood absorption at wound sites, and mechanical tunability indicated by good shape fidelity and printability during optimized 3D printing. Moreover, the DNA and biomineralized silica act as nanotherapeutics, enhancing the biological activity of the dressings in terms of reactive oxygen species scavenging, angiogenesis, and anti‐inflammation activity, thereby accelerating acute and diabetic wound healing. These bioinspired 3D‐printed hydrogels produce using a DNA‐induced biomineralization strategy are an excellent functional platform for clinical applications in acute and chronic wound repair.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v10.17
    DOI: 10.1002/advs.202300816
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    3D‐Printed Functional Hydrogel by DNA‐Induced Biomineralization for Accelerated Diabetic Wound Healing (Adv. Sci. 17/2023)
    Wiley ; 2023
    In:  Advanced Science Vol. 10, No. 17 ( 2023-06)
    Details
    In: Advanced Science, Wiley, Vol. 10, No. 17 ( 2023-06)
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v10.17
    DOI: 10.1002/advs.202370104
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 6
    Online Resource
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    MO489: Weight Change and Risk of Depression in Patients With Diabetic Kidney Disease: A Nationwide Population-Based Study
    Oxford University Press (OUP) ; 2022
    In:  Nephrology Dialysis Transplantation Vol. 37, No. Supplement_3 ( 2022-05-03)
    Details
    In: Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 37, No. Supplement_3 ( 2022-05-03)
    Abstract: Several studies have reported that depression has a high prevalence in patients with diabetes or chronic kidney disease. However, the relationship between weight changes and the risk of depression has not been elucidated in patients with diabetic kidney disease (DKD). METHOD From the Korean National Health Insurance Service database, we selected 67 866 patients with DKD with body weight data from two consecutive health examinations with a 2-year interval between 2009 and 2012. The weight change & gt;2 years was categorized into five groups: ≥10% weight loss, 5%–10% weight loss, & lt;5% weight change, 5%–10% weight gain and ≥10% weight gain. The occurrence of depression was monitored through the end of 2018 by the ICD-10 codes. RESULTS During the 5.24-year follow-up, 17 023 patients with DKD developed depression. The weight change and the risk of depression showed a U-shaped relationship: patients with ≥10% weight loss [hazard ratio (HR): 1.116] and those with ≥10% weight gain (HR: 1.114) showed higher HRs than those with ≤5% weight change, even after adjusting for several confounding factors. In subgroup analyses, the risk of depression tended to increase as weight gain or weight loss increased in all subgroups. CONCLUSION Both weight loss and weight gain increased the risk of depression in patients with DKD
    Type of Medium: Online Resource
    ISSN: 0931-0509 , 1460-2385
    URL: Article
    DOI: 10.1093/ndt/gfac071.020
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
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