In:
FEBS Letters, Wiley, Vol. 508, No. 3 ( 2001-11-23), p. 484-488
Kurzfassung:
We recently showed that FliC of Salmonella enteritidis increased human β‐defensin‐2 (hBD‐2) expression, and now describe the signaling responsible pathway. FliC increased the intracellular Ca 2+ concentration ([Ca 2+ ] in ) in Caco‐2 cells. The [Ca 2+ ] in increase induced by FliC was prevented by U73122 and heparin, but not by chelating extracellular Ca 2+ or pertussis toxin. The FliC‐induced increase in hBD‐2 promoter activity via nuclear factor κB (NF‐κB) was also inhibited by chelation of intracellular Ca 2+ or by U73122. We conclude that FliC increased [Ca 2+ ] in via inositol 1,4,5‐trisphosphate, which was followed by up‐regulating hBD‐2 mRNA expression via an NF‐κB‐dependent pathway.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(01)03088-5
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2001
ZDB Id:
1460391-3
SSG:
12
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