In:
Clinical Phytoscience, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2020-12)
Abstract:
Chemotherapy is the most widely used means of controlling trypanosomosis, however, effectiveness of the drugs available is limited by a number of factors. This study investigates the oxidative stress profile of aqueous extract of the fruit pulp of Adansonia digitata on some organs in rats infected with Trypanosoma brucei brucei . Methods Thirty-five male albino rats were divided into 7 groups of 5 rats each. Groups B, C, D, E, F and G were inoculated with 0.20 ml of suspension containing 10 6 T. b. brucei . Group A were neither infected nor treated. Group B were infected but not treated. At onset of parasitaemia, rats in group C were treated with diminazene aceturate at 3.5 mg/kg body weight once, while rats in group D were treated with vitamin C at 200 mg/kg body weight for 3 days consecutively. Rats in groups E, F and G were treated orally for 3 days with the aqueous extract of fruit pulp of A. digitata at a dosage of 40 mg/kg, 80 mg/kg and 160 mg/kg body weight respectively. Liver and kidney tissues of the rats were collected at necropsy (10 days PI) for oxidative stress analysis. Results There was a significant ( p 〈 0.05) effect in the concentration levels of malondialdehyde, superoxide dismutase , glutathione peroxidase and catalase among the different groups treated with aqueous extract of fruit pulp of A. digitata . Conclusion The extract of A. digitata exert protective effects against tissue peroxidation in albino rats experimentally infected with T . b . brucei .
Type of Medium:
Online Resource
ISSN:
2199-1197
DOI:
10.1186/s40816-020-00203-x
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2020
detail.hit.zdb_id:
2834057-7
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