In:
Annals of Neurology, Wiley, Vol. 11, No. 2 ( 1982-02), p. 177-181
Abstract:
In vitro immune function was assessed in patients with multiple sclerosis (MS) who were receiving Imuran therapy, in untreated MS patients, and in controls. In untreated stable MS patients, concanavalin A (Con A)‐driven mitogenic reactivity (T effector function) and Con A‐induced suppressor activity were modestly reduced compared to controls; pokeweed mitogen‐induced immunoglobulin G (IgG) secretion was increased. Untreated patients with active MS demonstrated high levels of IgG secretion and marked decreases in suppressor activity. In Imuran‐treated patients, Con A mitogenic responses and suppressor activity were comparable to those observed in untreated stable patients, and IgG secretion was reduced. The results in the treated patients likely reflect a direct effect of Imuran on B cell function rather than an indirect effect mediated via suppressor cells.
Type of Medium:
Online Resource
ISSN:
0364-5134
,
1531-8249
DOI:
10.1002/ana.410110211
Language:
English
Publisher:
Wiley
Publication Date:
1982
detail.hit.zdb_id:
2037912-2
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