In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 1 ( 2021-1-15), p. e0245131-
Abstract:
To establish the prevalence of multimorbidity in people with chronic kidney disease (CKD) stages 1–5 and transiently impaired renal function and identify factors associated with multimorbidity. Design and setting Prospective cohort study in UK primary care. Participants 861 participants aged 60 and older with decreased renal function of whom, 584 (65.8%) had CKD and 277 (32.2%) did not have CKD. Interventions Participants underwent medical history and clinical assessment, and blood and urine sampling. Primary and secondary outcome measures Multimorbidity was defined as presence of ≥2 chronic conditions including CKD. Prevalence of each condition, co-existing conditions and multimorbidity were described and logistic regression was used to identify predictors of multimorbidity. Results The mean (±SD) age of participants was 74±7 years, 54% were women and 98% were white. After CKD, the next most prevalent condition was hypertension (n = 511, 59.3%), followed by obesity (n = 265, 30.8%) ischemic heart disease (n = 145, 16.8%) and diabetes (n = 133, 15.4%). Having two co-existing conditions was most common (27%), the most common combination of which was hypertension and obesity (29%). One or three conditions was the next most prevalent combination (20% and 21% respectively). The prevalence of multimorbidity was 73.9% (95%CI 70.9–76.8) in all participants and 86.6% (95%CI 83.9–89.3) in those with any-stage CKD. Logistic regression found a significant association between increasing age (OR 1.07, 95%CI 1.04–0.10), increasing BMI (OR 1.15, 95%CI 1.10–1.20) and decreasing eGFR (OR 0.99, 95%CI 0.98–1.00) with multimorbidity. Conclusions This analysis is the first to provide an accurate estimate of the prevalence of multimorbidity in a screened older primary care population living with or at risk of CKD across all stages. Hypertension and obesity were the most common combination of conditions other than CKD that people were living with, suggesting that there may be multiple reasons for closely monitoring health status in individuals with CKD.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0245131
DOI:
10.1371/journal.pone.0245131.g001
DOI:
10.1371/journal.pone.0245131.g002
DOI:
10.1371/journal.pone.0245131.t001
DOI:
10.1371/journal.pone.0245131.t002
DOI:
10.1371/journal.pone.0245131.t003
DOI:
10.1371/journal.pone.0245131.t004
DOI:
10.1371/journal.pone.0245131.s001
DOI:
10.1371/journal.pone.0245131.s002
DOI:
10.1371/journal.pone.0245131.s003
DOI:
10.1371/journal.pone.0245131.s004
DOI:
10.1371/journal.pone.0245131.s005
DOI:
10.1371/journal.pone.0245131.s006
DOI:
10.1371/journal.pone.0245131.s007
DOI:
10.1371/journal.pone.0245131.r001
DOI:
10.1371/journal.pone.0245131.r002
DOI:
10.1371/journal.pone.0245131.r003
DOI:
10.1371/journal.pone.0245131.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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