In:
Pediatrics International, Wiley, Vol. 60, No. 3 ( 2018-03), p. 270-275
Abstract:
Neurological sequelae occur in 40% of patients with acute encephalopathy ( AE ). The early prediction of poor outcomes is critical to the initiation of appropriate treatment. The aim of the present study was therefore to elucidate prognostic factors that can be quickly and feasibly evaluated on hospital admission in patients with AE . Methods We analyzed data from 51 AE patients admitted to Hirakata City Hospital between January 2005 and December 2014. Age at onset, sex, underlying disease, status epilepticus ( SE ), presence of benzodiazepine‐resistant SE ( BZD ‐resistant SE ), and basic blood serum parameters on admission were evaluated in relation to each patient's outcome. Results On univariate analysis age at onset, BZD ‐resistant SE , and serum aspartate aminotransferase ( AST ), alanine aminotransferase, lactate dehydrogenase, and platelet count varied significantly according to outcome. On multivariate analysis age at onset (≤21 months), presence of BZD ‐resistant SE , and AST (≥46 IU /L) were identified as independent variables associated with poor outcome. Conclusion Age at onset, presence of BZD ‐resistant SE , and AST are associated with a poor prognosis in AE .
Type of Medium:
Online Resource
ISSN:
1328-8067
,
1442-200X
DOI:
10.1111/ped.2018.60.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2008621-0
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