In:
BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
Abstract:
Prostate cancer is a common cancer in men. Genetic variations in inflammatory response genes can potentially influence the risk of prostate cancer. We aimed to examine the association between PPARG Pro12Ala, NFKB1 -94 ins/del, NFKBIA -826C/T, COX-1 (50C 〉 T), and COX-2 (-1195G 〉 A) polymorphisms on prostate cancer risk. The genotypes of the polymorphisms were ascertained in 543 prostate cancer patients and 753 controls through PCR-RFLP and the risk association was evaluated statistically using logistic regression analysis. The NFKB1 -94 polymorphism was shown to decrease prostate cancer risk in both heterozygous and homozygous comparison models (odds ratios of 0.74 (95% CI = 0.58–0.96) ( P = 0.02 ) and 0.57 (95% CI = 0.42–0.78) ( P 〈 0.01 ), resp.). An opposite finding was observed for COX-2 (-1195) polymorphism (odds ratios of 1.58 (95% CI = 1.15–2.18) ( P 〈 0.01 ) for heterozygous comparison model and 2.08 (95% CI = 1.48–2.92) ( P 〈 0.01 ) for homozygous comparison model). No association was observed for other polymorphisms. In conclusion, NFKB1 -94 ins/del and COX-2 (-1195G 〉 A) polymorphisms may be, respectively, associated with decreased and increased prostate cancer risk in the Chinese population.
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2015
detail.hit.zdb_id:
2698540-8
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