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  • 1
    Online Resource
    Online Resource
    Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture ; 2023
    In:  The Indian Journal of Animal Sciences Vol. 93, No. 7 ( 2023-08-02)
    In: The Indian Journal of Animal Sciences, Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture, Vol. 93, No. 7 ( 2023-08-02)
    Abstract: Brucellosis is one of the most common contagious and neglected bacterial zoonotic diseases. The disease has been reported in ruminants in almost all Indian states. But there is a lack of comprehensive information on the seroprevalence of brucellosis in the Indian subcontinent. A systematic review and meta-analysis on the seroprevalence of brucellosis among ruminants of India was conducted from the published articles (January 1970 - June 2020) by including 172 studies screened from 567 publications. The estimated brucellosis seroprevalence of cattle, buffalo, sheep, goat, yak and mithun was 14% (95% CI: 12% - 16%), 8% (95% CI: 6% - 9%), 8% (95% CI: 7% - 10%), 8% (95% CI: 7% - 9%), 16% (95% CI: 7% - 28%) and 26% (95% CI: 12% - 42%), respectively. Sub-group analysiswas performed based on diagnostic tests, regions, publication year, and sample size. The estimated seroprevalence of brucellosis in cattle and goats was found to be higher in the central region compared to other regions. Similarly, the western region showed a higher seroprevalence for brucellosis in buffalo and sheep. Given the estimated animal population of 2021, the meta-analysis estimated that the total number of seropositive animals would be 26.95 million cattle (95% CI: 23.09–30.78), 8.78 million buffaloes (95% CI: 6.59–9.89), 5.94 million sheep (95% CI: 5.20–7.43), 11.91 million goats (95% CI: 10.42–13.40), 9.6 thousand yaks (95% CI: 0.0042–0.0168), and 100 thousand mithun (95% CI: 0.05–0.16). Further, the comprehensive picture of the brucellosis seroprevalence may help the decisionmaking authorities in formulating better prevention and control strategies for brucellosis in India.
    Type of Medium: Online Resource
    ISSN: 2394-3327 , 0367-8318
    Language: Unknown
    Publisher: Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture
    Publication Date: 2023
    detail.hit.zdb_id: 2558768-7
    SSG: 12,22
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  • 2
    Online Resource
    Online Resource
    Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture ; 2023
    In:  The Indian Journal of Animal Sciences Vol. 92, No. 7 ( 2023-08-02)
    In: The Indian Journal of Animal Sciences, Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture, Vol. 92, No. 7 ( 2023-08-02)
    Abstract: Brucellosis is one of the most common contagious and neglected bacterial zoonotic diseases. The disease has been reported in ruminants in almost all Indian states. But there is a lack of comprehensive information on the seroprevalence of brucellosis in the Indian subcontinent. A systematic review and meta-analysis on the seroprevalence of brucellosis among ruminants of India was conducted from the published articles (January 1970 - June 2020) by including 172 studies screened from 567 publications. The estimated brucellosis seroprevalence of cattle, buffalo, sheep, goat, yak and mithun was 14% (95% CI: 12% - 16%), 8% (95% CI: 6% - 9%), 8% (95% CI: 7% - 10%), 8% (95% CI: 7% - 9%), 16% (95% CI: 7% - 28%) and 26% (95% CI: 12% - 42%), respectively. Sub-group analysiswas performed based on diagnostic tests, regions, publication year, and sample size. The estimated seroprevalence of brucellosis in cattle and goats was found to be higher in the central region compared to other regions. Similarly, the western region showed a higher seroprevalence for brucellosis in buffalo and sheep. Given the estimated animal population of 2021, the meta-analysis estimated that the total number of seropositive animals would be 26.95 million cattle (95% CI: 23.09–30.78), 8.78 million buffaloes (95% CI: 6.59–9.89), 5.94 million sheep (95% CI: 5.20–7.43), 11.91 million goats (95% CI: 10.42–13.40), 9.6 thousand yaks (95% CI: 0.0042–0.0168), and 100 thousand mithun (95% CI: 0.05–0.16). Further, the comprehensive picture of the brucellosis seroprevalence may help the decisionmaking authorities in formulating better prevention and control strategies for brucellosis in India.
    Type of Medium: Online Resource
    ISSN: 2394-3327 , 0367-8318
    Language: Unknown
    Publisher: Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture
    Publication Date: 2023
    detail.hit.zdb_id: 2558768-7
    SSG: 12,22
    Location Call Number Limitation Availability
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  • 3
    Online Resource
    Online Resource
    Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture ; 2020
    In:  The Indian Journal of Animal Sciences Vol. 90, No. 3 ( 2020-07-17), p. 303-317
    In: The Indian Journal of Animal Sciences, Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture, Vol. 90, No. 3 ( 2020-07-17), p. 303-317
    Abstract: After the appearance of first cases of ‘pneumonia of unknown origin’ in the Wuhan city, China, during late 2019, the disease progressed fast. Its cause was identified as a novel coronavirus, named provisionally 2019-nCoV. Subsequently, an official name was given as SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) by the International Committee on Taxonomy of Viruses (ICTV) study group. The World Health Organization (WHO) named the Coronavirus disease-2019 as COVID-19. The epidemics of COVID-2019 have been recorded over 113 countries/territories/areas apart from China and filched more than 4,292 humans, affecting severely around 1,18,326 cases in a short span. The status of COVID-2019 emergency revised by the WHO within 42 days from Public Health International Emergency (January 30, 2020) to a pandemic (March 11, 2020). Nonetheless, the case fatality rate (CFR) of the current epidemic is on the rise (between 2–4%), relatively is lower than the previous SARS-CoV (2002/2003) and MERS-CoV (2012) outbreaks. Even though investigations are on its way, the researchers across the globe have assumptions of animal-origin of current SARS-CoV-2. A recent case report provides evidence of mild COVID-2019 infection in a pet dog that acquired COVID-2019 infection from his owner in Hong Kong. The news on travellers associated spread across the globe have also put many countries on alert with the cancellation of tourist visa to all affected countries and postponement of events where international visits were required. A few diagnostic approaches, including quantitative and differential real-time polymerase chain reaction assays, have been recommended for the screening of the individuals at risk. In the absence of any selective vaccine against SARS-CoV-2, re-purposed drugs are advocated in many studies. This article discourse the current worldwide situation of COVID-2019 with information on virus, epidemiology, host, the role of animals, effective diagnosis, therapeutics, preventive and control approaches making people aware on the disease outcomes.
    Type of Medium: Online Resource
    ISSN: 0367-8318
    Language: Unknown
    Publisher: Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture
    Publication Date: 2020
    detail.hit.zdb_id: 2558768-7
    SSG: 12,22
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  • 4
    In: Pathogens, MDPI AG, Vol. 9, No. 7 ( 2020-06-28), p. 519-
    Abstract: The technology-driven world of the 21st century is currently confronted with a major threat to humankind, represented by the coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus-2 (SARS-CoV-2). As of now, COVID-19 has affected more than 6 million confirmed cases and took 0.39 million human lives. SARS-CoV-2 spreads much faster than its two ancestors, SARS-CoV and Middle East respiratory syndrome-CoV (MERS-CoV), but has low fatality rates. Our analyses speculate that the efficient replication and transmission of SARS-CoV-2 might be due to the high-density basic amino acid residues, preferably positioned in close proximity at both the furin-like cleavage sites (S1/S2 and S2’) within the spike protein. Given the high genomic similarities of SARS-CoV-2 to bat SARS-like CoVs, it is likely that bats serve as a reservoir host for its progenitor. Women and children are less susceptible to SARS-CoV-2 infection, while the elderly and people with comorbidities are more prone to serious clinical outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. The cohesive approach amongst researchers across the globe has delivered high-end viral diagnostics. However, home-based point-of-care diagnostics are still under development, which may prove transformative in current COVID-19 pandemic containment. Similarly, vaccines and therapeutics against COVID-19 are currently in the pipeline for clinical trials. In this review, we discuss the noteworthy advancements, focusing on the etiological viral agent, comparative genomic analysis, population susceptibility, disease epidemiology and diagnosis, animal reservoirs, laboratory animal models, disease transmission, therapeutics, vaccine challenges, and disease mitigation measures.
    Type of Medium: Online Resource
    ISSN: 2076-0817
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2695572-6
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  • 5
    In: Tropical Animal Health and Production, Springer Science and Business Media LLC, Vol. 52, No. 1 ( 2020-1), p. 445-452
    Type of Medium: Online Resource
    ISSN: 0049-4747 , 1573-7438
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2005233-9
    SSG: 22
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  • 6
    In: Veterinary Quarterly, Informa UK Limited, Vol. 40, No. 1 ( 2020-01-01), p. 229-242
    Type of Medium: Online Resource
    ISSN: 0165-2176 , 1875-5941
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2141817-2
    SSG: 22
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  • 7
    In: Epidemiology and Infection, Cambridge University Press (CUP), Vol. 147 ( 2019)
    Abstract: A cross-sectional study was conducted from 2014 to 2017 in 13 organised pig farms located in eight states of India (Northern, North-Eastern and Southern regions) to identify the risk factors, pathotype and antimicrobial resistance of Escherichia coli associated with pre- and post-weaning piglet diarrhoea. The data collected through questionnaire survey were used to identify the risk factors by univariable analysis, in which weaning status, season, altitude, ventilation in the shed, use of heater/cooler for temperature control in the sheds, feed type, water source, and use of disinfectant, were the potential risk factors. In logistic regression model, weaning and source of water were the significant risk factors. The piglet diarrhoea prevalence was almost similar across the regions. Of the 909 faecal samples collected (North – 310, North-East – 194 and South – 405) for isolation of E. coli , pathotyping and antibiotic screening, 531 E. coli were isolated in MacConkey agar added with cefotaxime, where 345 isolates were extended spectrum β -lactamase (ESBL) producers and were positive for bla CTX-M-1 ( n = 147), bla TEM ( n = 151), qnr A ( n = 98), qnr B ( n = 116), qnr S ( n = 53), tet A ( n = 46), tet B ( n = 48) and sul 1 ( n = 54) genes. Multiple antibiotic resistance (MAR) index revealed that 14 (2.64%) isolates had MAR index of 1. On the virulence screening of E. coli , 174 isolates harboured alone or combination of Stx 1, Stx 2, eae A, hly A genes. The isolates from diarrhoeic and post-weaning samples harboured higher number of virulence genes than non-diarrhoeic and pre-weaning. Alleviating the risk factors might reduce the piglet diarrhoea cases. The presence of multidrug-resistant and ESBL-producing pathogenic E. coli in piglets appears a public health concern.
    Type of Medium: Online Resource
    ISSN: 0950-2688 , 1469-4409
    RVK:
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2019
    detail.hit.zdb_id: 1470211-3
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  • 8
    In: Veterinary Research Communications, Springer Science and Business Media LLC, Vol. 45, No. 2-3 ( 2021-09), p. 163-170
    Type of Medium: Online Resource
    ISSN: 0165-7380 , 1573-7446
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2011124-1
    SSG: 22
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  • 9
    In: Frontiers in Molecular Biosciences, Frontiers Media SA, Vol. 8 ( 2021-7-28)
    Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to coronavirus disease 2019 (COVID-19) pandemic affecting nearly 71.2 million humans in more than 191 countries, with more than 1.6 million mortalities as of 12 December, 2020. The spike glycoprotein (S-protein), anchored onto the virus envelope, is the trimer of S-protein comprised of S1 and S2 domains which interacts with host cell receptors and facilitates virus-cell membrane fusion. The S1 domain comprises of a receptor binding domain (RBD) possessing an N-terminal domain and two subdomains (SD1 and SD2). Certain regions of S-protein of SARS-CoV-2 such as S2 domain and fragment of the RBD remain conserved despite the high selection pressure. These conserved regions of the S-protein are extrapolated as the potential target for developing molecular diagnostic techniques. Further, the S-protein acts as an antigenic target for different serological assay platforms for the diagnosis of COVID-19. Virus-specific IgM and IgG antibodies can be used to detect viral proteins in ELISA and lateral flow immunoassays. The S-protein of SARS-CoV-2 has very high sequence similarity to SARS-CoV-1, and the monoclonal antibodies (mAbs) against SARS-CoV-1 cross-react with S-protein of SARS-CoV-2 and neutralize its activity. Furthermore, in vitro studies have demonstrated that polyclonal antibodies targeted against the RBD of S-protein of SARS-CoV-1 can neutralize SARS-CoV-2 thus inhibiting its infectivity in permissive cell lines. Research on coronaviral S-proteins paves the way for the development of vaccines that may prevent SARS-CoV-2 infection and alleviate the current global coronavirus pandemic. However, specific neutralizing mAbs against SARS-CoV-2 are in clinical development. Therefore, neutralizing antibodies targeting SARS-CoV-2 S-protein are promising specific antiviral therapeutics for pre-and post-exposure prophylaxis and treatment of SARS-CoV-2 infection. We hereby review the approaches taken by researchers across the world to use spike gene and S-glycoprotein for the development of effective diagnostics, vaccines and therapeutics against SARA-CoV-2 infection the COVID-19 pandemic.
    Type of Medium: Online Resource
    ISSN: 2296-889X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2814330-9
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  • 10
    Online Resource
    Online Resource
    Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture ; 2021
    In:  The Indian Journal of Animal Sciences Vol. 91, No. 10 ( 2021-10-26)
    In: The Indian Journal of Animal Sciences, Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture, Vol. 91, No. 10 ( 2021-10-26)
    Abstract: Of the 1,415 human pathogens identified, 175 are responsible for causing emerging diseases, 132 are zoonotic and majority of the diseases are categorized as emerging or re-emerging. Emerging novel Coronavirus (COVID- 19) is one of them, and it is responsible for causing social and economically critical disease in both humans and animals. This review presents the understanding of epidemiological characteristics of the COVID-19 pandemic related to host, agent, and the environment with transmission and spread of the disease for better prevention of the COVID-19. The inclination of the viruses to spillover between different species and determining the number of the reservoir of coronaviruses in an entirely new host to create infection is of emerging importance. The understanding of disease patterns will potentiate our expertise to alert how, when, and where the potential epidemic will occur. One health approach involves co-operation from all the sectors, including healthcare (medical and veterinary), environmental, pharmaceutical, educational, research, police, and administration, to combat the COVID-19 pandemic and reduce the public health threat.
    Type of Medium: Online Resource
    ISSN: 0367-8318
    Language: Unknown
    Publisher: Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture
    Publication Date: 2021
    detail.hit.zdb_id: 2558768-7
    SSG: 12,22
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