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  • 1
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    Online Resource
    Evaluasi Pengobatan Covid-19 di Rumah Sakit Bahteramas Provinsi Sulawesi Tenggara Tahun 2020-2021
    Program Studi Farmasi STIKES Mandala Waluya ; 2023
    In:  Jurnal Mandala Pharmacon Indonesia Vol. 9, No. 1 ( 2023-06-30), p. 71-79
    Details
    In: Jurnal Mandala Pharmacon Indonesia, Program Studi Farmasi STIKES Mandala Waluya, Vol. 9, No. 1 ( 2023-06-30), p. 71-79
    Abstract: Covid-19 merupakan penyakit yang disebabkan oleh SARS-CoV-2 yang menginfeksi seluruh dunia di akhir tahun 2019. Data WHO Per April 2021 melaporkan 141.057.106 kasus yang terkonfirmasi COVID-19. Di Indonesia terdapat 1.609.300 kasus dan di Sulawesi Tenggara khususnya Rumah Sakit Bahteramas pasien yang telah di konfirmasi positif sebanyak 609 orang. Dalam pengobatan Covid-19, Rumah Sakit memberikan berbagai macam terapi untuk mengobati berbagai gejala yang ditimbulkan akibat infeksi Covid-19. Tujuan penelitian ini adalah untuk mengetahui gambaran terapi Covid-19 dengan mengikuti kesesuaian pedoman Covid-19 di Rumah Sakit Bahteramas tahun 2020-2021. Penelitian ini merupakan penelitian deskriptif dengan pendekatan retrospektif melalui pengambilan data rekam medik pada pasien Covid-19 di Rumah Sakit Bahteramas Provinsi Sulawesi Tenggara dengan jumlah sampel penelitian ini sebanyak 154. Hasil penelitian ini menunjukkan penggunaan obat pada pasien Covid-19 terdiri dari terapi antivirus; oseltamivir 18% dan favipiravir 5%, golongan antibiotik; azitromisin 17% dan levoflaksasin 2% dan terapi supportif; paracetamol 8%, asetilsistein 16%, deksametason 1%, lanzoprasol 1%, vitamin C 16%, zink 2%, become C® 10%, becefort® 3%, Amlodipine 1%. Pengobatan pasien Covid-19 yang diberikan di Rumah Sakit Bahteramas telah sesuai dengan pedoman Kementerian Kesehatan Republik Indonesia tahun 2020.
    Type of Medium: Online Resource
    ISSN: 2598-9979 , 2442-6032
    URL: Issue
    URL: Article
    DOI: 10.35311/jmpi.v9i1
    DOI: 10.35311/jmpi.v9i1.300
    Language: Unknown
    Publisher: Program Studi Farmasi STIKES Mandala Waluya
    Publication Date: 2023
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  • 2
    Online Resource
    Online Resource
    Antibacterial Activities of Kacapiring Leaf Ethanol Extract (Gardenia jasminoides Ellis) on the Bacteria of Staphylococcus aureus and Propionibacterium acnes
    Universitas Halu Oleo ; 2019
    In:  MEDULA Vol. 6, No. 3 ( 2019-11-28)
    Details
    In: MEDULA, Universitas Halu Oleo, Vol. 6, No. 3 ( 2019-11-28)
    Abstract: ABSTRACTBackground and Objective(s): Infection is the process of entering pathogenic bacteria or microorganisms into the body capable of causing disease. Bacterial infections can cause skin infections such as acne. Acne is inflammation that is accompanied by blockage of the oil glands of the skin and hair (pilosebasea duct). Gardenia jasminoides Ellis is a plant that empirically can be used to treat infectious diseases caused by bacteria. This study was conducted to determine the antibacterial activity of the extracts of kacapiring leaves (Gardenia jasminoides Ellis) against Staphylococcus aureus and Propionibacterium acnes bacteria. Methods: Making extracts was done by maceration method  using  96% ethanol. The concentrations of extracts  used  were 5%, 10% and  15%,  with chloramphenicol and clindamycin as positive controls and distilled water as negative controls. Antibacterial activity was tested by the Cup-plate technique. Results: The antibacterial activity of kacapiring leaves ethanol extract to S. aureus showed that at concentrations of 5%, 10% and 15% the inhibitory power diameters values were respectively 5.58 mm, 9.3 mm and 11.41 mm while the antibacterial activity of extracts kacapiring leaves ethanol to P. acnes bacteria at concentrations of 5%, 10% and 15% had inhibitory power diameters of 6.33 mm, 9.25 mm and 11 mm respectively. Conclusion: Ethanol extract of kacapiring leaves has antibacterial activity against Staphylococcus aureus and Propionibacterium acnes bacteria. At a concentration of 5% and 10%, it shows the moderate category and at a concentration of 15% shows a strong category.Keywords: antibacterial, cup-plate technique , gardenia jasminoides
    Type of Medium: Online Resource
    ISSN: 2443-0218 , 2339-1006
    URL: Issue
    URL: Article
    DOI: 10.46496/medula.v6i3
    DOI: 10.46496/medula.v6i3.9652
    Language: Unknown
    Publisher: Universitas Halu Oleo
    Publication Date: 2019
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  • 3
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    Online Resource
    SOSIALISASI DAN EDUKASI TENTANG BAHAYA NARKOBA PADA MASYARAKAT PESISIR DI SMPN SATU ATAP TAPULAGA KECAMATAN SOROPIA
    Universitas Halu Oleo ; 2023
    In:  Mosiraha: Jurnal Pengabdian Farmasi Vol. 1, No. 1 ( 2023-03-27), p. 20-24
    Details
    In: Mosiraha: Jurnal Pengabdian Farmasi, Universitas Halu Oleo, Vol. 1, No. 1 ( 2023-03-27), p. 20-24
    Abstract: Narkoba adalah singkatan dari narkotika, psikotropika dan bahan adiktif lainnya. Istilah lainnya  adalah  NAPZA  (narkotika,  psikotropika  dan  zat  adiktif). Salah satu kelompok masyarakat yang rawan terpapar penyalahgunaan Narkoba yaitu pada rentang usia 15-35 tahun atau generasi milenial. Kelompok usia remaja justru memiliki keinginan yang besar untuk mencoba-coba, mengikuti trend dan gaya hidup, serta memilih hidup bersenang senang.  Tujuan dari pengabdian ini yaitu dilakukannya kegiatan sosialisasi mengenai bahaya penyalahgunaan narkoba di Sekolah Menengah Pertama (SMP) Negeri Satu Atap Tapulaga  untuk meningkatkan pemahaman tentang dampak yang ditimbulkan dari penggunaan narkoba, baik secara fisik, psikis maupun sosial ekonomi. Metode yang diberikan berupa informasi melalui penyuluhan, leaflet dan media sosial. Hasil dari kegiatan pengabdian yang telah dilakukan yaitu bertambahnya pengetahuan Siswa/Siswi SMPN Satu Atap Desa Tapulaga tentang bahaya penggunaan narkoba dan mendapatkan informasi yang jelas mengenai narkoba.
    Type of Medium: Online Resource
    ISSN: 2986-8165
    URL: Issue
    URL: Article
    DOI: 10.33772/mosiraha.v1i1
    DOI: 10.33772/mosiraha.v1i1.4
    Language: Unknown
    Publisher: Universitas Halu Oleo
    Publication Date: 2023
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  • 4
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    Online Resource
    Uji Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Notika (Arcboldiodendron calosericeum Kobuski) Terhadap Kadar Kolesterol Total Tikus (Rattus norvegicus) Jantan Galur Wistar
    Universitas Negeri Gorontalo ; 2019
    In:  Journal Syifa Sciences and Clinical Research Vol. 2, No. 1 ( 2019-11-13), p. 1-10
    Details
    In: Journal Syifa Sciences and Clinical Research, Universitas Negeri Gorontalo, Vol. 2, No. 1 ( 2019-11-13), p. 1-10
    Abstract: Hyperlipidemia is an increase of lipid due to excessive fat consumption, that the intake and alteration of lipid is not balanced. Notika are plants that contain secondary metabolites in the form of flavonoids, tannins, saponins and triterpenoids which are antioxidant compounds that are thought to have the effect of reducing blood lipids. This study aims to determine the effect of ethanol extract of leaves of Notika on decreasing total cholesterol levels in rats induced by egg and propylthiouracil (PTU). This research was experimental in 6 groups, namely 4 groups given ethanol extract of leaves of Notika at a dose of 50 mg/kgBB, 100 mg/kgBB, 200 mg/kgBB, and 300 mg/kgBB, one group was given Na CMC 0.5% as a negative control, and one group was given simvastatin 10 mg as a positive control. The results showed that the ethanol extract of the leaves of Notika significantly reduced the total cholesterol level of rats with a significant value 0.05 and 300 mg/kgBB is an effective dose to reduce total cholesterol level.
    Type of Medium: Online Resource
    ISSN: 2656-9612 , 2656-8187
    URL: Article
    DOI: 10.37311/jsscr.v2i1.2704
    Language: Unknown
    Publisher: Universitas Negeri Gorontalo
    Publication Date: 2019
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  • 5
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    Online Resource
    Uji Toksisitas Akut Ekstrak Air Dan Ekstrak Etanol Daun Kacapiring (Gardenia jasminoides Ellis) Terhadap Larva Artemia Salina Leach Dengan Metode Brine Shrimp Lethality Test (BSLT)
    Universitas Negeri Gorontalo ; 2021
    In:  Indonesian Journal of Pharmaceutical Education Vol. 1, No. 2 ( 2021-05-30), p. 98-106
    Details
    In: Indonesian Journal of Pharmaceutical Education, Universitas Negeri Gorontalo, Vol. 1, No. 2 ( 2021-05-30), p. 98-106
    Abstract: A toxicity test is a test to detect the toxic effect of a substance on a biological system and to obtain typical dose-response data from the test preparation. This study aims to determine the content of secondary metabolites from the aqueous extract and ethanolic extract of gardenia leaves, characterization of gardenia leaf extract, and acute toxicity using the BSLT method against Artemia salina Leach shrimp larvae.Phytochemical screening tests were carried out by the color change method which included the alkaloid test, flavonoid test, tannin test, saponin test, and terpenoid test. Extract characterization tests include determination of water-soluble extract, determination of ethanol-soluble extract, determination of water content, and determination of ash content. Acute toxicity test using the Brine Shrimp Lethality Test (BSLT) method using Artemia salina Leach shrimp larvae.The results of the phytochemical screening test for the aqueous extract of gardenia leaves showed positive results on saponins, while the phytochemical screening tests on ethanol extracts showed positive results on alkaloids, flavonoids, saponins, tannins, and terpenoids. The results of the characterization test on the aqueous extract of gardenia leaves were that the ethanol-soluble extract content was 20.19%, the water-soluble extract content was 23.17%, the water content was 99.13% and the ash content was 0.29%. Meanwhile, in the ethanolic extract of gardenia leaves, the ethanol-soluble extract content was 60.80%, the water-soluble extract content was 57.14%, the water content was 7.87% and the ash content was 3.22%. The results show that gardenia leaves are not toxic with the LC50 value of the water extract of the gardenia leaves is 1399.64 g/mL and the LC50 value of the ethanolic extract of the gardenia leaves is 1080.96 so that it can be used as traditional medicine. 
    Type of Medium: Online Resource
    ISSN: 2775-3670
    URL: Issue
    URL: Article
    DOI: 10.37311/ijpe.v1i2
    DOI: 10.37311/ijpe.v1i2.11462
    Language: Unknown
    Publisher: Universitas Negeri Gorontalo
    Publication Date: 2021
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  • 6
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    Inhibition of Xanthine Oxidase Activity by Ethanolic Extract of Piperomia pellucida L., Acacypha indica L. and Momordica charantia L.
    Secretariat of The Indonesian Biomedical Journal ; 2016
    In:  The Indonesian Biomedical Journal Vol. 8, No. 3 ( 2016-12-01), p. 161-
    Details
    In: The Indonesian Biomedical Journal, Secretariat of The Indonesian Biomedical Journal, Vol. 8, No. 3 ( 2016-12-01), p. 161-
    Abstract: BACKGROUND: Uric acid is a final result of purine catabolism, the enzymatic reactions in the body cells from amino acids or ribonucleotide dinucleotide. Peperomia pellucida L. (P. pellucida), Acalypha indica L. (A. indica) and Momordica charantia L. (M. charantia) are plants which have efficacy to reduce levels of uric acid excess. The aim of this research is to find out the effect of ethanol extract of P. pellucida, A. indica and M. charantia in preventing the formation of uric acid excess by inhibiting the action of the enzyme xanthine oxidase and comparing the inhibition activity of xanthine oxidase on treatments.METHODS: The study design is experimental and conducted using the enzyme xanthine oxidase, xanthine (substrate), pH 7.5 phosphate buffer, samples (P. pellucida, A. indica and M. charantia ethanol extracts) and HCL as reaction breaker. Inhibition of xanthine oxidase was determined enzymatically and unreacted xanthine was measured by UV spectrophotometer at 290 nm. The data were expressed as percent inhibition and the inhibitory concentration (IC)50 were determined using linear regresion of inhibition activity vs. concentration.RESULTS: The IC50 of P. pellucida, A. indica and M. charantia ethanol extracts in inhibiting xanthine oxidase were 19.5 ppm, 77.6 ppm and 17.8 ppm, respectively. IC50 of allopurinol was 1.99 μg/ml, and negative control (combination of enzyme and substrate) has absorbance value of 0.75026.CONCLUSION: Ethanol extract of M. charantia showed the most potent inhibition toward xanthine oxidase compared to the other two extracts.KEYWORDS: xanthine oxidase, Peperomia pellucida L., Acalypha indica L., Momordica charantia L.
    Type of Medium: Online Resource
    ISSN: 2355-9179 , 2085-3297
    URL: Article
    DOI: 10.18585/inabj.v8i3.194
    Language: Unknown
    Publisher: Secretariat of The Indonesian Biomedical Journal
    Publication Date: 2016
    detail.hit.zdb_id: 2838032-0
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  • 7
    Online Resource
    Online Resource
    Momordica charantia L. Fruit Fractions inhibit Malondialdehyde Level and Regenerate Hepatic Damage of Hyperglycemic Rats
    Secretariat of The Indonesian Biomedical Journal ; 2020
    In:  The Indonesian Biomedical Journal Vol. 12, No. 1 ( 2020-03-19), p. 57-61
    Details
    In: The Indonesian Biomedical Journal, Secretariat of The Indonesian Biomedical Journal, Vol. 12, No. 1 ( 2020-03-19), p. 57-61
    Abstract: BACKGROUND: Chronic hyperglycemia causes an increase of free radical production and in longterm, the hyperglycemia increases oxidative stress. Among medicinal plants, Momordica charantia L. fruit has been known to overcome hyperglycemia. However, role of M. charantia L. fruit on oxidative stress is not well understood. Therefore, current study was conducted to investigate the effect of M. charantia L. fruit extract on malondialdehyde (MDA) level and hepatic damage in hyperglicemic rat model.METHODS: Twenty five white rats (Rattus novergicus) were induced with Streptozotocin (STZ) and treated with/without glibenclamide, sodium carboxymethyl cellulose (Na-CMC), or M. charantia L. fruit ethanol/ethyl acetate/ n-hexane fraction. After the treatment, rat’s livers were collected and separated for histopathological examination and MDA analysis.RESULTS: The MDA level average of rats before the STZ induction was 1.37 μg/mL. MDA level average was markedly increased (23.85 μg/mL) in rats induced with STZ and treated with Na-CMC merely. The MDA level average of STZ-induced glibenclamide-treated rats was 3.12 μg/mL. Meanwhile, the MDA level averages of STZ-induced M. charantia L. fruit ethanol, ethyl acetate and n-hexane fractions-treated rats were 14.95, 8.98 and 5.37 μg/mL, respectively. The histopathology results of this study showed that adipocytes, dilated sinusoids and central vein thickening were mostly observed in STZ-induced Na-CMC-treated rats. Meanwhile, the STZ-induced ethanol/ethyl acetate/n-hexane fraction-treated rats did not exhibitthose expressions.CONCLUSION: M. charantia L. fruit fractions inhibit the MDA level average in liver tissue and regenerate hepatic damage of STZ-induced rats, especially the n-hexane fraction which could be a potential hepatic antioxidant and regenerative agent.KEYWORDS: Momordica charantia L., malondialdehyde, oxidative stress, hyperglycemia, diabetes mellitus
    Type of Medium: Online Resource
    ISSN: 2355-9179 , 2085-3297
    URL: Article
    DOI: 10.18585/inabj.v12i1.963
    Language: Unknown
    Publisher: Secretariat of The Indonesian Biomedical Journal
    Publication Date: 2020
    detail.hit.zdb_id: 2838032-0
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  • 8
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    Online Resource
    Immunomodulatory Effect of Momordica charantia L. Fruit Ethanol Extract on Phagocytic Activity and Capacity of Mice Peritoneal Macrophages
    Secretariat of The Indonesian Biomedical Journal ; 2018
    In:  The Indonesian Biomedical Journal Vol. 10, No. 2 ( 2018-08-02), p. 144-7
    Details
    In: The Indonesian Biomedical Journal, Secretariat of The Indonesian Biomedical Journal, Vol. 10, No. 2 ( 2018-08-02), p. 144-7
    Abstract: BACKGROUND: The purpose of this research is to understand the secondary metabolites of Momordica charantia L. extract, as well as to disclose the potential of M. charantia extract in the phagocytic activity and capacity of peritoneummacrophages.METHODS: Examination of immunomodulatory effect was done by giving M. charantia ethanol extract on 5 treatment groups, given intra-peritoneally to mice daily. Echinacea extract as positive control and double distilled water as negative control were also given. On the 8th day, mice were infected with Staphylococcus epidermidis. After 30 minutes, peritoneum fluid was obtained to observe the activity and capacity of macrophage cells.RESULTS: The results showed significant phagocytic activity (p 〈 0.05) at a concentration of 1,200 ppm compare to the other groups. Meanwhile the macrophage cell capacity was found statistically insignificant (p 〉 0.05). The highest phagocytic activity was the group treated with 1,200 ppm (62%), significantly higher than other groups.CONCLUSION: The secondary metabolite content of M. charantia is alkaloids, flavonoids, tannins, saponins, and triterpenoids. The 1,200 ppm M. charantia ethanol extract is potential in inducing phagocytic activity and capacity. These results indicate that the M. charantia can be suggested as a natural immunomodulator.KEYWORDS: pare fruit, Momordica charantia L., phagocytosis, macrophage, immunomodulator
    Type of Medium: Online Resource
    ISSN: 2355-9179 , 2085-3297
    URL: Article
    DOI: 10.18585/inabj.v10i2.390
    Language: Unknown
    Publisher: Secretariat of The Indonesian Biomedical Journal
    Publication Date: 2018
    detail.hit.zdb_id: 2838032-0
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  • 9
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    Pengaruh Fraksi Ekstrak Buah Pare (Momordica Charantia L.) Terhadap Penurunan Kadar Glukosa Darah Tikus yang Diinduksi Streptozotocin
    Universitas Padjadjaran ; 2020
    In:  Majalah Farmasetika. Vol. 4 ( 2020-01-23)
    Details
    In: Majalah Farmasetika., Universitas Padjadjaran, Vol. 4 ( 2020-01-23)
    Abstract: Pare adalah tanaman yang sering dimanfaatkan sebagai obat tradisional dalam menyembuhkan berbagai jenis penyakit, diantaranya diabetes mellitus. Kandungan charantine, polypeptide-p, vicine dan antioksidan memiliki potensi menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui aktivitas anti diabetik fraksi ekstrak buah pare dalam menurunkan kadar glukosa darah dan gambaran histopatologi jaringan pankreas tikus yang diinduksi streptozotocin. Penelitian ini menggunakan post test only control group design. Sampel penelitian ini terdiri dari 5 kelompok yaitu kelompok kontrol positif, kelompok kontrol negatif, kelompok fraksi etanol ekstrak buah pare, kelompok fraksi etil asetat ekstrak buah pare, dan kelompok n-heksan ekstrak buah pare. Pengukuran kadar glukosa darah dilakukan pada saat sebelum dilakukannya induksi STZ, setelah induksi STZ, hari ke 4 dan hari ke 7 pemberian fraksi ekstrak buah pare menggunakan glukometer dan spektrofotometer. Pada hari ke 7 dilakukan pembedahan untuk pengambilan sampel darah dan pankreas tikus. Analisis data yang digunakan adalah kruskal-wallis dilanjutkan uji mann-withney. Berdasarkan hasil penelitian, diketahui terdapat perbedaan yang signifikan antara penurunan kadar glukosa darah tikus diabetes mellitus yang diberi fraksi n-heksan ekstrak buah pare dengan kelompok kontrol negatif (p-value 〈 0,05). Sementara itu berdasarkan pemeriksaan histopatologi jaringan pankreas tikus yang diberi fraksi ekstrak buah pare 400 mg/kg diperoleh nilai positif ++. Terdapat aktivitas anti diabetik fraksi ekstrak buah pare dengan presentase tingkat penurunan kadar glukosa darah tikus tertinggi oleh pemberian fraksi n-heksan ekstrak buah pare 400 mg/kg. Terdapat perbedaan gambaran histopatologi jaringan pankreas tikus pada kelompok yang diberi fraksi etanol, fraksi etil asetat, dan fraksi n-heksan terhadap kelompok kontrol positif dan kontrol negatif.
    Type of Medium: Online Resource
    ISSN: 2686-2506
    URL: Issue
    URL: Article
    DOI: 10.24198/mfarmasetika.v4i0
    DOI: 10.24198/mfarmasetika.v4i0.25863
    Language: Unknown
    Publisher: Universitas Padjadjaran
    Publication Date: 2020
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  • 10
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    Evaluasi Mutu Pelayanan Kefarmasian di Puskesmas Seluruh Kota Kendari
    Universitas Airlangga ; 2021
    In:  JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8, No. 2 ( 2021-08-29), p. 107-
    Details
    In: JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA, Universitas Airlangga, Vol. 8, No. 2 ( 2021-08-29), p. 107-
    Abstract: Pendahuluan: Tujuan evaluasi mutu pelayanan adalah untuk mengevaluasi seluruh rangkaian kegiatan pelayanan kefarmasian dan sebagai dasar perbaikan pelayanan kefarmasian selanjutnya sehingga meningkatkan kualitas hidup pasien. Tujuan: Penelitian ini dilakukan untuk mengetahui mutu pelayanan kefarmasian di seluruh Puskesmas di Kota Kendari berdasarkan permenkes nomor 74 tahun 2016. Metode: Penelitian ini merupakan penelitian observasional yang bersifat deksriptif menggunakan desain cross sectional. Mutu pelayanan yang diukur adalah kepuasan pasien, dimensi waktu pelayanan dan ketersediaan serta pelaksanaan Standar Operational Procedure/SOP. Instrumen yang digunakan adalah kuesioner kepuasan pasien, pedoman wawancara dan lembar observasi. Parameter penilaian mutu pelayanan kefarmasian di Puskesmas yang digunakan adalah Permenkes no. 44 tahun 2016 tentang pedoman manajemen mutu di Puskesmas, dengan kategori baik yaitu 〉 8,5, cukup 5,5 – 8,4, dan kategori kurang yaitu 〈 5,5 yang didapat dari nilai rata-rata empat skala nilai. Hasil: Tingkat kepuasan pasien didapatkan 79,51% kategori cukup (skala nilai = 7), sedangkan untuk dimensi waktu pelayanan obat yaitu 80% puskesmas telah menetapkan waktu pelayanan baik obat racikan maupun non racikan dengan skala nilai 7. Hanya 59,04% (skala nilai 7) puskesmas yang menerapkan standar prosedur pelayanan (SOP) minimal sesuai permenkes RI nomor. 74 tahun 2016. Dalam pelaksanaan pelayanan kefarmasian oleh farmasis didapatkan 43,65% pada skala nilai 4. Kesimpulan: Secara keseluruhan rata-rata nilai mutu pelayanan kefarmasian seluruh Puskesmas di Kota Kendari adalah 6,25 atau kategori cukup.
    Type of Medium: Online Resource
    ISSN: 2580-8303 , 2406-9388
    URL: Article
    DOI: 10.20473/jfiki.v8i22021.107-116
    Language: Unknown
    Publisher: Universitas Airlangga
    Publication Date: 2021
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