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  • 1
    In: Sanitarnyj vrač (Sanitary Doctor), PANORAMA Publishing House, , No. 3 ( 2023-02-20), p. 153-163
    Abstract: The pandemic of the new COVID-19 infection has had an impact on the epidemic process of most known infectious diseases. Given the high pandemic potential and the economic damage caused by influenza and SARS, the assessment of the prevalence of these infections in modern realities seems relevant. Aim: to assess the current manifestations of the epidemic process of SARS and influenza during the COVID-19 pandemic. Official statistics data were used to study the manifestations of epidemic processes of influenza and SARS. For serological examination, blood serum samples from conditionally healthy adults (N=270) collected in February 2022 were used. The titer of IgG antibodies to strains of influenza virus H1N1 pnm09, influenza H3N2, influenza B (Phuket), influenza B (Washington) was determined using a hemagglutination inhibition reaction. The samples were examined by enzyme immunoassay for the presence of IgG antibodies to adenovirus, respiratory syncytial (RS) virus, metapneumovirus, rhinovirus and parainfluenza viruses of types 1 and 3. Against the background of the development of the COVID-19 pandemic, an increase in the incidence of influenza has been established to a maximum value in 2021 (65.99 per 100 thousand population). The prevalence of influenza in the capital was 4.6 times higher than the average in Russia (14.96 per 100 thousand population). A significant proportion of persons immune to the influenza virus (more than 60 %) with a maximum value for the influenza B virus was identified, which is consistent with the data on the prevalence of this variant of the pathogen in the etiological interpretation of the incidence in 2021. Among the pathogens of ARVI, the maximum proportion of seropositive was detected to rhinovirus (77.8 %), which corresponds to the data on the greatest prevalence of this pathogen in the etiological structure of this group of infections. The active circulation of the influenza virus and the vaccination of the population became the basis for the formation of a high level of population immunity to the corresponding virus, which was shown by the results of the assessment of the prevalence of specific IgG antibodies.
    Type of Medium: Online Resource
    ISSN: 2074-8841
    URL: Issue
    Language: Unknown
    Publisher: PANORAMA Publishing House
    Publication Date: 2023
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  • 2
    In: Journal of microbiology, epidemiology and immunobiology, Central Research Institute for Epidemiology, Vol. 98, No. 4 ( 2021-09-21), p. 468-480
    Abstract: The aim of the study — demonstration of the capabilities of new generation geographic information system software and agent-based modeling for solving epidemiological problems (on the example of the spread of measles in a metropolis).Materials and methods. Examples of the use of thematic layers and the functionality of the geoinformation platform, as well as the developed multi-agent model of measles spread in the megalopolis, are given. The measles spread model is presented as following three independent sub-models or nested models: behavior model, infection model, infectious process model. The modularity and independence of the sub-models allow the useof the necessary statistical and clinical data, both directly related to the studied disease and demographic indicators, which are analyzed and stored in the thematic layers of the platform.Results. The developed software tools allow visualizing, analyzing and short-term forecasting of the spread of the disease in the study area, with the ability to generate reports, which can be a useful and relevant addition to the daily work of specialists, contribute to the improvement and deepening of practical skills and abilities, in accordance with the types and tasks of professional activities, as well as expand opportunities for assistance in management decision making.
    Type of Medium: Online Resource
    ISSN: 2686-7613 , 0372-9311
    Language: Unknown
    Publisher: Central Research Institute for Epidemiology
    Publication Date: 2021
    SSG: 12
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  • 3
    In: Epidemiology and Vaccinal Prevention, LLC Numicom, Vol. 21, No. 4 ( 2022-09-12), p. 4-15
    Abstract: Annualy, SARS occupy a leading position in terms of morbidity and the magnitude of the economic damage caused both in the world and in the Russian Federation. Currently, the most widespread pandemics are caused by the influenza A (H1N1) pdm09 virus and the new SARS-CoV-2 coronavirus, which occupy a common ecological niche and require studying the manifestations of the epidemic process of ARVI for further development of measures to improve epidemiological surveillance of this group of infections. Aim of the study was to investigate the current manifestations of the epidemic process of ARVI and influenza, including in the context of a new coronavirus infection (COVID–19) pandemic, on the territory of Russia and in Moscow. Materials and methods. The assessment of the long-term dynamics of the incidence of ARVI and influenza (from 1999 to 2021), as well as its age structure in the territory of the Russian Federation and in Moscow, was carried out. The main sources of information were: WHO: «The situation with COVID-19 in the European region», the domestic information portal Stopkoronavirus.rf, as well as data from Federal State Statistical Observation forms No. 2 and No. 6. Results. During the period 2013–2019, a strong positive correlation was revealed between the incidence rates of ARVI in the Russian Federation and Moscow (p = 0.8, with p 〈 0.05), which became negative with the spread of SARS-CoV-2: in the country, the incidence rate of ARVI increased by 11.5% in 2020 and 15.6% in 2021., in Moscow there was a decrease of 45.1% than the average in Russia, which could be due to the quality of differential diagnosis of ARVI and COVID-19. In 2021 the incidence rate of influenza decreased by more than 2 times in all Federal Districts of the country, with the exception of the capital region, where it became the maximum - 65.9 per 100 thousand population in 2021 (against 14.1 in 2019). In the age structure of influenza incidence, as well as ARVI, for the period from 2019 to 2021. the child population prevailed with the highest rates in the age groups of 1–2 years and 3–6 years. As the circulation of SARS-Cov-2 decreased to 15–19%, the activity of influenza viruses and other pathogens of the ARVI group increased (from 0.7–3.0% during the developed pandemic to 5.6–6.6% at the stage of its decline), which indicates a pronounced interference of pathogens detected at the global level in the system of Global Hospital Surveillance for flu. Conclusion. The forecast for the upcoming epidemic season 2022–2023 largely depends on the spread of the new coronavirus SARS-CoV-2, as well as its variability and the emergence of new variants. Nevertheless, there may be a significant increase in the incidence caused by the influenza A(H1N1)pdm09 virus, whose high activity was recorded in the current epidemic season in a number of countries in the Southern hemisphere.
    Type of Medium: Online Resource
    ISSN: 2619-0494 , 2073-3046
    Language: Unknown
    Publisher: LLC Numicom
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    Pleiades Publishing Ltd ; 2008
    In:  Russian Journal of Nondestructive Testing Vol. 44, No. 2 ( 2008-2), p. 86-90
    In: Russian Journal of Nondestructive Testing, Pleiades Publishing Ltd, Vol. 44, No. 2 ( 2008-2), p. 86-90
    Type of Medium: Online Resource
    ISSN: 1061-8309 , 1608-3385
    Language: English
    Publisher: Pleiades Publishing Ltd
    Publication Date: 2008
    detail.hit.zdb_id: 2058228-6
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  • 5
    In: Epidemiology and Vaccine Prevention, LLC Numicom, Vol. 16, No. 3 ( 2017-06-20), p. 11-15
    Abstract: The aim of the study was to determine the role of foreign citizens registered in Moscow region, in the maintenance of the epidemic process of measles, rubella and mumps based on the basis of their susceptibility to these infections and compare with the control group (residents of the Russia Central Federal District - donors of blood). Materials and methods. Examination included 909 samples of blood sera obtained from migrant workers and 939 blood donors (residents of the Central Federal district of Russia) which were tested for the presence of antibodies (IgG) to measles, rubella and mumps with the help of enzyme-linked immunosorbent assay. Results. Average relative density of seronegative persons among the surveyed migrants and donors to rubella virus ranged from 6.6 to 9.8%, the measles virus - 13.5 and 16.5%, respectively, statistically significant distinctions in groups were not established. The proportion of seronegative persons to mumps virus twice and more exceeded the standard documentation level among migrants and donors (32.5 and 47.5% respectively). Conclusion. There was a significant excess of the permissible level of seronegative persons to the measles, rubella and mumps viruses among migrant workers and blood donors, which creates preconditions for maintenance of epidemic process and dictates the necessity of carrying out the corrective vaccination (or revaccination) of non-immune persons
    Type of Medium: Online Resource
    ISSN: 2073-3046
    URL: Issue
    Language: Unknown
    Publisher: LLC Numicom
    Publication Date: 2017
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  • 6
    In: Genes & Cells, PJSC Human Stem Cells Institute, Vol. 15, No. 1 ( 2020-03-15), p. 50-59
    Abstract: Cell mosaicism is found in biological systems much more often than clinically identified forms of the disease, in some cases, "erased forms” or "normal variants” are phenotypic manifestations of mosaicism. Some diseases, difficult for a clinical diagnosis, such as ataxia-telangiectasia, are based on cell mosaicism. This work is aimed to study DNA repair disorders in the cell lines of dermal fibroblasts isolated from skin biopsies of 5 patients with a clinically diagnosed ataxia-telangiectasia. In the obtained cell lines, the method of indirect immunofluorescence was used to determine the number, intensity, focus area pATMSer1981 and 53BP1, as well as the number of cells with the active form of the ATM kinase. The mosaic pattern of malfunctioning of the active form of the ATM kinase, phospho-ATM Ser1981, was revealed at different time intervals after exposure to ionizing radiation at a dose of 2 Gy. Significant differences were found between the number of ATMSer1981 and 53BP1 foci, the fluorescence intensity and their area in the cells of patients with ataxia-telangiectasia and healthy donors. The results of this work can be used in the diagnosis of ataxia-telangiec-tasia and determining the degree of impairment of the functional activity of the ATM gene.
    Type of Medium: Online Resource
    ISSN: 2500-2562 , 2313-1829
    Language: Unknown
    Publisher: PJSC Human Stem Cells Institute
    Publication Date: 2020
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  • 7
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 1973
    In:  Bulletin of Experimental Biology and Medicine Vol. 76, No. 4 ( 1973-10), p. 1244-1246
    In: Bulletin of Experimental Biology and Medicine, Springer Science and Business Media LLC, Vol. 76, No. 4 ( 1973-10), p. 1244-1246
    Type of Medium: Online Resource
    ISSN: 0007-4888 , 1573-8221
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1973
    detail.hit.zdb_id: 2037110-X
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Central Research Institute for Epidemiology ; 2017
    In:  Journal of microbiology, epidemiology and immunobiology Vol. 94, No. 3 ( 2017-06-28), p. 91-98
    In: Journal of microbiology, epidemiology and immunobiology, Central Research Institute for Epidemiology, Vol. 94, No. 3 ( 2017-06-28), p. 91-98
    Abstract: Aim. Qualitative and quantitative evaluation of humoral immunity regarding causative agents of controllable infections in pregnant women in Moscow. Materials and methods. Sera of 559 pregnant and 201 non-pregnant women were studied for the presence of antibodies against measles and rubella virus by ELISA. Results. A significant proportion of individuals seronegative to measles was detected among pregnant (21.5%) and non-pregnant (29.1%) women aged 18 - 45, that exceeds the level acceptable by regulatory requirements by 3.1 and 4.2 times, respectively. The parameter increased with age and among seropositive individuals a high concentration of IgG against measles was noted. This gives evidence, that older individuals are not covered by measles vaccination enough, and a significant part of them has post-infection immunity that is higher and more robust compared with post-vaccination. Regarding rubella infection, a more favorable situation was established: proportion of seronegative individuals among the examined was 8.9 and 10.5%, respectively. The proportion of seronegative individuals decreased with age, and by age 36 - 45 reached the minimal 4,7%. A maximum amount of rubella seronegative individuals was detected in the 26-30 age group - 12.5%, as well as maximum proportion of individuals who have high concentration of specific IgG. An increase of the amount of seronegative results was observed with the increase of gestation period for both infections. Correlation between intensity of immunity against measles and rubella in the examined women was not present. Conclusion. Means for development of extra vaccination of the adult population and execution of laboratory examination of pregnant and women planning pregnancy are proposed regarding not only rubella, but also measles.
    Type of Medium: Online Resource
    ISSN: 2686-7613 , 0372-9311
    URL: Issue
    Language: Unknown
    Publisher: Central Research Institute for Epidemiology
    Publication Date: 2017
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    LLC Numicom ; 2015
    In:  Epidemiology and Vaccine Prevention Vol. 14, No. 6 ( 2015-12-20), p. 16-22
    In: Epidemiology and Vaccine Prevention, LLC Numicom, Vol. 14, No. 6 ( 2015-12-20), p. 16-22
    Abstract: The retrospective epidemiological analysis of measles in Moscow for the period from 1992 to 2014 shows the decisive role of mass vaccination for achievement of epidemiological well-being on measles. In 2007 Russia had reached the incidence rate less than one case per million population which is recommended by WHO for implementation of the program of measles elimination in the country. Nevertheless Moscow and Russian Federation show the rise of the infection since 2011. The paper analyses the dynamics of measles incidence among Moscow population, the age structure and disease focus, as well as outlines a possible range of causes that resulted in the complication of the epidemiological situation.
    Type of Medium: Online Resource
    ISSN: 2073-3046
    URL: Issue
    Language: Unknown
    Publisher: LLC Numicom
    Publication Date: 2015
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  • 10
    Online Resource
    Online Resource
    LLC Numicom ; 2019
    In:  Epidemiology and Vaccinal Prevention Vol. 18, No. 2 ( 2019-05-01), p. 18-26
    In: Epidemiology and Vaccinal Prevention, LLC Numicom, Vol. 18, No. 2 ( 2019-05-01), p. 18-26
    Type of Medium: Online Resource
    ISSN: 2619-0494 , 2073-3046
    URL: Issue
    Language: Unknown
    Publisher: LLC Numicom
    Publication Date: 2019
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