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  • 1
    Online Resource
    Online Resource
    Stroke genetics informs drug discovery and risk prediction across ancestries
    Springer Science and Business Media LLC ; 2022
    In:  Nature Vol. 611, No. 7934 ( 2022-11-03), p. 115-123
    Details
    In: Nature, Springer Science and Business Media LLC, Vol. 611, No. 7934 ( 2022-11-03), p. 115-123
    Abstract: Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry 1,2 . Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated ( P   〈  0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis 3 , and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN ) and variants (such as at GRK5 and NOS3 ). Using a three-pronged approach 4 , we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry 5 . Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
    URL: Article
    DOI: 10.1038/s41586-022-05165-3
    RVK:
    TA 1000
    RVK:
    UA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
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  • 2
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    Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries
    Springer Science and Business Media LLC ; 2022
    In:  Nature Vol. 612, No. 7938 ( 2022-12-01), p. E7-E7
    Details
    In: Nature, Springer Science and Business Media LLC, Vol. 612, No. 7938 ( 2022-12-01), p. E7-E7
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
    URL: Article
    DOI: 10.1038/s41586-022-05492-5
    RVK:
    TA 1000
    RVK:
    UA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 120714-3
    detail.hit.zdb_id: 1413423-8
    SSG: 11
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  • 3
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    Functional traits contribute in opposite directions to taxonomic turnover in northeastern US forests over time
    Wiley ; 2022
    In:  Journal of Vegetation Science Vol. 33, No. 1 ( 2022-01)
    Details
    In: Journal of Vegetation Science, Wiley, Vol. 33, No. 1 ( 2022-01)
    Abstract: Aims: Understanding the processes driving forest dynamics requires considering that species within communities do not respond in a coordinated manner to external factors. We argue that temporal turnover in species composition results from contrasting differences in species life history and functional strategies (demography and seed and wood traits) that might simultaneously promote stability and dynamism by operating on distinct subsets of species. Specifically, fast taxonomic turnover should be promoted by species that take advantage of sporadically available resources, while forest stability should be promoted by species with conservative and stress‐tolerant life histories. Location: Northeastern USA. Methods: We combine demographic information (survival, recruitment) over a 14‐year period from temperate tree communities in the northeastern United States with trait information on species seed mass and wood density as a proxy for their reproductive and resource acquisition strategies, to evaluate the differential contribution of species with contrasting ecological strategies (low vs high seed mass/wood density) to rates of compositional turnover in temperate forests. Results: The apparent dynamism of US forests is mostly driven by high mortality and low recruitment of small‐seeded species and by high mortality and recruitment of low wood density species. Simultaneously, species with the opposite traits, i.e., high seed mass and wood density, contribute more to stability. Our findings suggest that forests dynamics in the northeastern United States are the outcome of opposing contributions of life history and plant traits that simultaneously promote forest stability and rapid taxonomic turnover by operating differentially across tree species. Conclusions: Small‐seeded and low wood density species promote faster forest turnover than species with the opposite traits. Not accounting for these functional differences in community‐level analyses is likely to mask the complex dynamics of temperate forests. This study demonstrates the importance of studying forest composition and structure under a dynamic scope that accounts for differences in functional strategies across species.
    Type of Medium: Online Resource
    ISSN: 1100-9233 , 1654-1103
    URL: Issue
    URL: Article
    DOI: 10.1111/jvs.v33.1
    DOI: 10.1111/jvs.13116
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 4
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    BioTIME: A database of biodiversity time series for the Anthropocene
    Wiley ; 2018
    In:  Global Ecology and Biogeography Vol. 27, No. 7 ( 2018-07), p. 760-786
    Details
    In: Global Ecology and Biogeography, Wiley, Vol. 27, No. 7 ( 2018-07), p. 760-786
    Abstract: The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community‐led open‐source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene. Main types of variables included The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains metadata relating to sampling methodology and contextual information about each record. Spatial location and grain BioTIME is a global database of 547,161 unique sampling locations spanning the marine, freshwater and terrestrial realms. Grain size varies across datasets from 0.0000000158 km 2 (158 cm 2 ) to 100 km 2 (1,000,000,000,000 cm 2 ). Time period and grain BioTIME records span from 1874 to 2016. The minimal temporal grain across all datasets in BioTIME is a year. Major taxa and level of measurement BioTIME includes data from 44,440 species across the plant and animal kingdoms, ranging from plants, plankton and terrestrial invertebrates to small and large vertebrates. Software format .csv and .SQL.
    Type of Medium: Online Resource
    ISSN: 1466-822X , 1466-8238
    URL: Issue
    URL: Article
    DOI: 10.1111/geb.2018.27.issue-7
    DOI: 10.1111/geb.12729
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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    detail.hit.zdb_id: 2021283-5
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  • 5
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    Individual‐level trait variation and negative density dependence affect growth in tropical tree seedlings
    Wiley ; 2018
    In:  Journal of Ecology Vol. 106, No. 6 ( 2018-11), p. 2446-2455
    Details
    In: Journal of Ecology, Wiley, Vol. 106, No. 6 ( 2018-11), p. 2446-2455
    Abstract: Individual‐level interactions with neighbours and their surrounding environments are key factors influencing performance that ultimately shape and maintain diversity in tropical plant communities. Theory predicts that the strength of these interactions depends on the similarity among neighbours, the turnover in composition caused by individuals that enter as new recruits and individuals that die, and fitting to local conditions. Despite considerable phenotypic variation among individuals and high community dynamics, these three factors have rarely been considered together for understanding growth variation, especially for seedling communities in the tropics. We address this outstanding challenge by quantifying the influence of trait dissimilarity among neighbours, temporal turnover in neighbours, and individual trait variation on seedling growth, based on an unprecedented dataset containing individual‐level demographic and functional trait data for tropical tree seedlings. The results showed that trait dissimilarity associated with resource acquisition does not influence growth. However, conspecific negative density‐dependent effects on growth were evident through the initial density of conspecifics and the increase in conspecifics during the study period. Also, individuals with relatively larger investments in leaf biomass allocation attained higher growth rates, suggesting that seedlings adjust their resource allocation to tissues related with light capture. Synthesis . Together, these findings indicate that tropical seedling communities are structured by local abiotic factors that ultimately result in individual variation in resource acquisition traits and by biotic interactions driven by negative density dependence. These biotic interactions are highly dynamic and depend on conspecifics turnover, even at short temporal scales. Thus, to gain further insights into the forces structuring seedling communities, future studies should account for temporal variability in immediate neighbours and individual‐level phenotypic variation that influence individual interactions.
    Type of Medium: Online Resource
    ISSN: 0022-0477 , 1365-2745
    URL: Issue
    URL: Article
    DOI: 10.1111/jec.2018.106.issue-6
    DOI: 10.1111/1365-2745.13001
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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  • 6
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    Determinants of Plant Community Assembly in a Mosaic of Landscape Units in Central Amazonia: Ecological and Phylogenetic Perspectives
    Public Library of Science (PLoS) ; 2012
    In:  PLoS ONE Vol. 7, No. 9 ( 2012-9-18), p. e45199-
    Details
    In: PLoS ONE, Public Library of Science (PLoS), Vol. 7, No. 9 ( 2012-9-18), p. e45199-
    Type of Medium: Online Resource
    ISSN: 1932-6203
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1371/journal.pone.0045199
    DOI: 10.1371/journal.pone.0045199.s001
    DOI: 10.1371/journal.pone.0045199.s002
    DOI: 10.1371/journal.pone.0045199.s003
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2012
    detail.hit.zdb_id: 2267670-3
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  • 7
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    FunAndes – A functional trait database of Andean plants
    Springer Science and Business Media LLC ; 2022
    In:  Scientific Data Vol. 9, No. 1 ( 2022-08-20)
    Details
    In: Scientific Data, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2022-08-20)
    Abstract: We introduce the FunAndes database, a compilation of functional trait data for the Andean flora spanning six countries. FunAndes contains data on 24 traits across 2,694 taxa, for a total of 105,466 entries. The database features plant-morphological attributes including growth form, and leaf, stem, and wood traits measured at the species or individual level, together with geographic metadata (i.e., coordinates and elevation). FunAndes follows the field names, trait descriptions and units of measurement of the TRY database. It is currently available in open access in the FIGSHARE data repository, and will be part of TRY’s next release. Open access trait data from Andean plants will contribute to ecological research in the region, the most species rich terrestrial biodiversity hotspot.
    Type of Medium: Online Resource
    ISSN: 2052-4463
    URL: Article
    DOI: 10.1038/s41597-022-01626-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2775191-0
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  • 8
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    Above-ground biomass and productivity in a rain forest of eastern South America
    Cambridge University Press (CUP) ; 2008
    In:  Journal of Tropical Ecology Vol. 24, No. 4 ( 2008-07), p. 355-366
    Details
    In: Journal of Tropical Ecology, Cambridge University Press (CUP), Vol. 24, No. 4 ( 2008-07), p. 355-366
    Abstract: The dynamics of tropical forest woody plants was studied at the Nouragues Field Station, central French Guiana. Stem density, basal area, above-ground biomass and above-ground net primary productivity, including the contribution of litterfall, were estimated from two large permanent census plots of 12 and 10 ha, established on contrasting soil types, and censused twice, first in 1992–1994, then again in 2000–2002. Mean stem density was 512 stems ha −1 and basal area, 30 m 2 ha −1 . Stem mortality rate ranged between 1.51% and 2.06% y −1 . In both plots, stem density decreased over the study period. Using a correlation between wood density and wood hardness directly measured by a Pilodyn wood tester, we found that the mean wood density was 0.63 g cm −3 , 12% smaller than the mean of wood density estimated from the literature values for the species occurring in our plot. Above-ground biomass ranged from 356 to 398 Mg ha −1 (oven-dry mass), and it increased over the census period. Leaf biomass was 6.47 Mg ha −1 . Our total estimate of aboveground net primary productivity was 8.81 MgC ha −1 y −1 (in carbon units), not accounting for loss to herbivory, branchfalls, or biogenic volatile organic compounds, which may altogether account for an additional 1 MgC ha −1 y −1 . Coarse wood productivity (stem growth plus recruitment) contributed to 4.16 MgC ha −1 y −1 . Litterfall contributed to 4.65 MgC ha −1 y −1 with 3.16 MgC ha −1 y −1 due to leaves, 1.10 MgC ha −1 y −1 to twigs, and 0.39 MgC ha −1 y −1 to fruits and flowers. The increase in above-ground biomass for both trees and lianas is consistent with the hypothesis of a shift in the functioning of Amazonian rain forests driven by environmental changes, although alternative hypotheses such as a recovery from past disturbances cannot be ruled out at our site, as suggested by the observed decrease in stem density.
    Type of Medium: Online Resource
    ISSN: 0266-4674 , 1469-7831
    URL: Article
    DOI: 10.1017/S0266467408005075
    RVK:
    WA 15000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2008
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  • 9
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    Influence of frugivore activity on the species abundance of seedlings and saplings in a lowland tropical forest in Colombia
    Cambridge University Press (CUP) ; 2015
    In:  Journal of Tropical Ecology Vol. 31, No. 4 ( 2015-07), p. 291-303
    Details
    In: Journal of Tropical Ecology, Cambridge University Press (CUP), Vol. 31, No. 4 ( 2015-07), p. 291-303
    Abstract: Although seed dispersal plays a critical role for plant regeneration, the long-term benefits of frugivores for recruitment success have been poorly explored. We evaluated the relative importance of tree species abundance and of frugivore-related factors for successful plant recruitment on 18 tree species in a lowland Colombian rain forest. We combined census data from four 1-ha plots of trees ( 〉 10 cm dbh), saplings (1–5 cm dbh) and seedlings ( 〈 1.7 m) with a dataset describing tree–frugivore interactions. Seedling abundance was higher for large-seeded species dispersed by the spider monkey, while sapling abundance was higher for large-seeded species dispersed by birds. The identity of the dispersal agent and its interaction with seed size explained 20–30% of the total variance in seedling and sapling abundance across scales. Seed size consistently influenced the species abundance of seedlings and saplings across scales, but in opposite ways. These developmental changes suggest that what is beneficial to seedlings is not necessarily beneficial to saplings. Species identity explained 10–50% of the total variance in seedling and sapling abundance among and within 1-ha plots. Overall, our findings suggest that recruitment success is context-dependent as the relative importance of the different variables addressed may shift along spatial and temporal scales.
    Type of Medium: Online Resource
    ISSN: 0266-4674 , 1469-7831
    URL: Article
    DOI: 10.1017/S0266467415000164
    RVK:
    WA 15000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2015
    detail.hit.zdb_id: 1466679-0
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  • 10
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    DE PORQUÉ LA REGENERACIÓN NATURAL ES TAN IMPORTANTE PARA LA COEXISTENCIA DE ESPECIES EN LOS BOSQUES TROPICALES
    Universidad Distrital Francisco Jose de Caldas ; 2014
    In:  Colombia Forestal Vol. 17, No. 2 ( 2014-12-31), p. 247-
    Details
    In: Colombia Forestal, Universidad Distrital Francisco Jose de Caldas, Vol. 17, No. 2 ( 2014-12-31), p. 247-
    Type of Medium: Online Resource
    ISSN: 0120-0739 , 2256-201X
    URL: Article
    DOI: 10.14483/udistrital.jour.colomb.for.2014.2.a08
    Language: Unknown
    Publisher: Universidad Distrital Francisco Jose de Caldas
    Publication Date: 2014
    detail.hit.zdb_id: 2720400-5
    SSG: 7,36
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