In:
Zeitschrift für Naturforschung C, Walter de Gruyter GmbH, Vol. 65, No. 1-2 ( 2010-2-1), p. 43-48
Abstract:
Lichen phenolic compounds exhibit antioxidant, antimicrobial, antiproliferative, and cytotoxic activities. The purpose of this study was to evaluate the anticancer activity of lecanoric acid, a secondary metabolite of the lichen Parmotrema tinctorum, and its derivatives, orsellinates, obtained by structural modifi cation. A cytotoxicity assay was carried out in vitro with sulforhodamine B (SRB) using HEp-2 larynx carcinoma, MCF7 breast carcinoma, 786-0 kidney carcinoma, and B16-F10 murine melanoma cell lines, in addition to a normal (Vero) cell line in order to calculate the selectivity index of the compounds. n-Butyl orsellinate was the most active compound, with IC 50 values (the concentration that inhibits 50% of growth) ranging from 7.2 to 14.0 μg/mL, against all the cell lines tested. The compound was more active (IC 50 = 11.4 μg/mL) against B16-F10 cells than was cisplatin (12.5 μg/mL). Conversely, lecanoric acid and methyl orsellinate were less active against all cell lines, having an IC 50 value higher than 50 μg/mL. Ethyl orsellinate was more active against HEp-2 than against MCF7, 786-0, or B16-F10 cells. The same pattern was observed for n-propyl and n-butyl orsellinates. n-Pentyl orsellinate was less active than n-propyl or n-butyl orsellinates against HEp-2 cells. The orsellinate activity increased with chain elongation (from methyl to n-butyl), a likely consequence of an increase in lipophilicity. The results revealed that the structural modifi cation of lecanoric acid increases the cytotoxic activity of the derivatives tested.
Type of Medium:
Online Resource
ISSN:
1865-7125
,
0939-5075
DOI:
10.1515/znc-2010-1-208
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2010
detail.hit.zdb_id:
2078107-6
SSG:
12
Permalink