In:
Cancer Immunology, Immunotherapy, Springer Science and Business Media LLC, Vol. 71, No. 1 ( 2022-01), p. 203-217
Abstract:
Lipids have immunomodulatory functions and the potential to affect cancer immunity. Methods The associations of pretreatment serum cholesterol and long-chain fatty acids with the objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were evaluated in 148 patients with non-small cell lung cancer who received nivolumab. Results When each lipid was separately evaluated, increased low-density lipoprotein (LDL)-cholesterol ( P 〈 0.001), high-density lipoprotein (HDL)-cholesterol ( P = 0.014), total cholesterol ( P = 0.007), lauric acid ( P = 0.015), myristic acid ( P = 0.022), myristoleic acid ( P = 0.035), stearic acid ( P = 0.028), linoleic acid ( P = 0.005), arachidic acid ( P = 0.027), eicosadienoic acid ( P = 0.017), dihomo-γ-linolenic acid ( P = 0.036), and behenic acid levels ( P = 0.032) were associated with longer PFS independent of programmed death ligand 1 (PD-L1) expression. Meanwhile, increased LDL-cholesterol ( P 〈 0.001), HDL-cholesterol ( P = 0.009), total cholesterol ( P = 0.036), linoleic acid ( P = 0.014), and lignoceric acid levels ( P = 0.028) were associated with longer OS independent of PD-L1 expression. When multiple lipids were evaluated simultaneously, LDL-cholesterol ( P = 0.003), HDL-cholesterol ( P = 0.036), and lauric acid ( P = 0.036) were independently predictive of PFS, and LDL-cholesterol ( P = 0.008) and HDL-cholesterol ( P = 0.031) were predictive of OS. ORR was not associated with any serum lipid. Conclusions Based on the association of prolonged survival in patients with increased serum cholesterol and long-chain fatty acid levels, serum lipid levels may be useful for predicting the efficacy of immune checkpoint inhibitor therapy.
Type of Medium:
Online Resource
ISSN:
0340-7004
,
1432-0851
DOI:
10.1007/s00262-021-02979-4
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2022
detail.hit.zdb_id:
1458489-X
detail.hit.zdb_id:
195342-4
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