In:
Journal of The Royal Society Interface, The Royal Society, Vol. 12, No. 113 ( 2015-12), p. 20150830-
Abstract:
Despite the well-known design principles of vascular systems, it is unclear whether the vascular arterial tree obeys some scaling constraints during normal growth and ageing in a given species. Based on the micro-computed tomography measurements of coronary arterial trees in mice at different ages (one week to more than eight months), we show a constant exponent of 3/4, but age-dependent scaling coefficients in a length–volume scaling law ( L c is the crown length, V c is the crown volume, K length–volume is the age-dependent scaling coefficient) during normal growth and ageing. The constant 3/4 exponent represents the self-similar fractal-like branching pattern (i.e. basic mechanism to regulate the development of vascular trees within a species), whereas the age-dependent scaling coefficients characterize the structural growth or resorption of vascular trees during normal growth or ageing, respectively. This study enhances the understanding of age-associated changes in vascular structure and function.
Type of Medium:
Online Resource
ISSN:
1742-5689
,
1742-5662
DOI:
10.1098/rsif.2015.0830
Language:
English
Publisher:
The Royal Society
Publication Date:
2015
detail.hit.zdb_id:
2156283-0
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