In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 4 ( 2022-4-14), p. e0266806-
Abstract:
Fatty acids salts exhibit bacteriostatic and bactericidal effects to inhibit bacterial growth and survival. Bacteria adapt to their environment to overcome these antibacterial effects through undefined mechanisms. In Gram-negative bacteria, drug efflux systems are associated with resistance to various substances. Studies have identified multiple drug efflux systems in Salmonella enterica . The aim of this study was to investigate whether drug efflux systems contribute to fatty acid salts resistance in S . enterica . We used deletion and overexpressing strains of S . enterica for drug efflux transporters. Susceptibility to fatty acid salts was determined by measuring minimum inhibitory concentrations and performing growth assays. Our findings revealed that acrAB , acrEF , emrAB and tolC in S . enterica contribute resistance to fatty acid salts. Furthermore, EmrAB, which is known to function with TolC, contributes to the fatty acid salts resistance of S . enterica in a TolC-independent manner. This study revealed that drug efflux systems confer fatty acid satls resistance to S . enterica . Notably, although EmrAB is normally associated with antimicrobial resistance in a TolC-dependent manner, it was found to be involved in fatty acid salts resistance in a TolC-independent manner, indicating that the utilization of TolC by EmrAB is substrate dependent in S . enterica .
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0266806
DOI:
10.1371/journal.pone.0266806.g001
DOI:
10.1371/journal.pone.0266806.g002
DOI:
10.1371/journal.pone.0266806.g003
DOI:
10.1371/journal.pone.0266806.g004
DOI:
10.1371/journal.pone.0266806.g005
DOI:
10.1371/journal.pone.0266806.t001
DOI:
10.1371/journal.pone.0266806.t002
DOI:
10.1371/journal.pone.0266806.t003
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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