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  • 1
    Online Resource
    Online Resource
    Effects of Apnea, Obesity, and Statin Therapy on Proprotein Convertase Subtilisin/Kexin 9 Levels in Patients with Obstructive Sleep Apnea
    S. Karger AG ; 2022
    In:  Medical Principles and Practice Vol. 31, No. 3 ( 2022), p. 293-300
    Details
    In: Medical Principles and Practice, S. Karger AG, Vol. 31, No. 3 ( 2022), p. 293-300
    Abstract: 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 Obstructive sleep apnea (OSA) is a common condition closely related to obesity, insulin resistance, dyslipidemia, and cardiovascular disease. The aim of this study was to explore the possible relationship between OSA and proprotein convertase subtilisin/kexin type 9 ( 〈 i 〉 PCSK9 〈 /i 〉 ). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Full-night polysomnography was performed on 150 participants who were divided into three groups: controls, OSA patients on statin therapy, and OSA patients not on statin therapy. Biochemical markers, plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses, and 〈 i 〉 PCSK9 〈 /i 〉 were determined. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 〈 i 〉 PCSK9 〈 /i 〉 was highest in OSA patients on statins compared to the control group and to OSA patients not on statins ( 〈 i 〉 p 〈 /i 〉 = 0.036 and 〈 i 〉 p 〈 /i 〉 = 0.039, respectively), after adjustment for body mass index (BMI). LDL diameter was greater in OSA patients not on statins compared to OSA patients on statins ( 〈 i 〉 p 〈 /i 〉 = 0.032). 〈 i 〉 PCSK9 〈 /i 〉 was highest in the group of patients with all three risk factors (diagnosed OSA, statins, BMI ≥25 kg/m 〈 sup 〉 2 〈 /sup 〉 ) compared to groups with no, one, and two risk factors ( 〈 i 〉 p 〈 /i 〉 = 0.031, 〈 i 〉 p 〈 /i 〉 = 0.001, and 〈 i 〉 p 〈 /i 〉 = 0.029, respectively). Presence of OSA, statin therapy, and BMI ≥25 kg/m 〈 sup 〉 2 〈 /sup 〉 when combined were independently associated with higher levels of 〈 i 〉 PCSK9 〈 /i 〉 when adjusted for antihypertensive therapy, small dense LDL, and HDL 3c subclass (odds ratio = 2.849; interquartile range [1.026–7.912], 〈 i 〉 p 〈 /i 〉 = 0.044). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Statin therapy was closely related to 〈 i 〉 PCSK9 〈 /i 〉 . OSA along with obesity and statin use induces elevation of 〈 i 〉 PCSK9 〈 /i 〉 .
    Type of Medium: Online Resource
    ISSN: 1011-7571 , 1423-0151
    URL: Article
    DOI: 10.1159/000524087
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 1482963-0
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  • 2
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    Alterations of cholesterol synthesis and absorption in obstructive sleep apnea: Influence of obesity and disease severity
    Elsevier BV ; 2022
    In:  Nutrition, Metabolism and Cardiovascular Diseases Vol. 32, No. 12 ( 2022-12), p. 2848-2857
    Details
    In: Nutrition, Metabolism and Cardiovascular Diseases, Elsevier BV, Vol. 32, No. 12 ( 2022-12), p. 2848-2857
    Type of Medium: Online Resource
    ISSN: 0939-4753
    URL: Article
    DOI: 10.1016/j.numecd.2022.09.006
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2050914-5
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  • 3
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    Non-Coding RNAs in Preeclampsia—Molecular Mechanisms and Diagnostic Potential
    MDPI AG ; 2021
    In:  International Journal of Molecular Sciences Vol. 22, No. 19 ( 2021-09-30), p. 10652-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 22, No. 19 ( 2021-09-30), p. 10652-
    Abstract: Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Defects in trophoblast invasion, differentiation of extravillous trophoblasts and spiral artery remodeling are key factors in PE development. Currently there are no predictive biomarkers clinically available for PE. Recent technological advancements empowered transcriptome exploration and led to the discovery of numerous non-coding RNA species of which microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the most investigated. They are implicated in the regulation of numerous cellular functions, and as such are being extensively explored as potential biomarkers for various diseases. Altered expression of numerous lncRNAs and miRNAs in placenta has been related to pathophysiological processes that occur in preeclampsia. In the following text we offer summary of the latest knowledge of the molecular mechanism by which lnRNAs and miRNAs (focusing on the chromosome 19 miRNA cluster (C19MC)) contribute to pathophysiology of PE development and their potential utility as biomarkers of PE, with special focus on sample selection and techniques for the quantification of lncRNAs and miRNAs in maternal circulation.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms221910652
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 4
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    Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 22 ( 2022-11-14), p. 14995-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 22 ( 2022-11-14), p. 14995-
    Abstract: Adiponectin (ADIPOQ) as both a regulator of metabolic homeostasis and a protein involved in immune response might be of particular interest to contemporary laboratory medicine, especially in terms of minimally invasive diagnostics. The diverse roles of ADIPOQ with regard to the immune and metabolic aspects of colorectal carcinogenesis have been proposed. However, the expression of its receptors ADIPOR1 and ADIPOR2 is scarcely explored in peripheral blood mononuclear cells (PBMCs). Moreover, ADIPORs’ relationships with the immune response mediator TNF-α have not been previously investigated in the PBMCs of CRC patients. This study used both in silico and observational case–control analyses with the aim of exploring the association of ADIPOR gene expression and ADIPOQ single nucleotide polymorphisms (SNPs) with the inflammatory marker TNF-α and lipid status parameters in patients with CRC. Publicly available transcriptomic datasets (GSE47756, GSE44076) obtained from analyses of monocytes and CRC tissue samples were employed for the in silico evaluation of ADIPORs’ specific genetic traits. GSE47756 and GSE44076 datasets were processed with GSEA software to provide a genetic fingertip of different signaling pathways associated with ADIPORs’ mRNA levels. The case–control aspect of the study included the PBMC samples of 73 patients diagnosed with CRC and 80 healthy volunteers. The PCR method was carried out for the PBMC gene expression analysis (ADIPOR1, ADIPOR2, TNF-α mRNA levels) and for the subjects’ genotyping (ADIPOQ rs266729, ADIPOR1 rs7539542). GSEA showed significant associations of ADIPOR mRNA expression with gene sets related to metabolic and immune homeostasis in both datasets. The case–control study revealed the association of ADIPOR1 rs7539542 with reduced lipid status parameters in CRC. In addition, PBMC ADIPOR1 mRNA levels decreased in CRC (p 〈 0.001), whereas ADIPOR2 mRNA did not differ between the groups (p = 0.442). A reduction in PBMC TNF-α mRNA levels was noted in CRC (p 〈 0.05). Our results indicate that ADIPOR1 and ADIPOR2 play a significant role in the alteration of both metabolic and immune homeostasis during the progression of CRC. For the first time, ADIPOR1 is shown to be a specific receptor for mediating ADIPOQ’s effects in the PBMCs of CRC patients.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph192214995
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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  • 5
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    Successful use of sirolimus for refractory atrial ectopic tachycardia in a child with cardiac rhabdomyoma
    Wiley ; 2017
    In:  Annals of Noninvasive Electrocardiology Vol. 22, No. 4 ( 2017-07)
    Details
    In: Annals of Noninvasive Electrocardiology, Wiley, Vol. 22, No. 4 ( 2017-07)
    Abstract: Cardiac rhabdomyomas are common in tuberous sclerosis. We report a child who developed rhabdomyoma related arrhythmia refractory to antiarrhythmic drug therapy. Reversion of the atrial ectopic tachycardia was achieved with mammalian target of rapamycin pathway ( mTOR ) inhibitor sirolimus. As per our knowledge, this is the first time that sirolimus has been successfully used in this setting.
    Type of Medium: Online Resource
    ISSN: 1082-720X , 1542-474X
    URL: Issue
    URL: Article
    DOI: 10.1111/anec.2017.22.issue-4
    DOI: 10.1111/anec.12435
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2111515-1
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  • 6
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    Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-1-27), p. 1-9
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-1-27), p. 1-9
    Abstract: Different byproducts of oxidative stress do not always lead to the same conclusion regarding its relationship with cardiometabolic risk, since controversial results are reported so far. The aim of the current study was to examine prooxidant determinant ((prooxidant-antioxidant balance (PAB)) and the marker of antioxidant defence capacity (total sulphydryl groups (tSHG)), as well as their ratio (PAB/tSHG) in relation to different cardiometabolic risk factors in the cohort of adult population. Additionally, we aimed to examine the joint effect of various cardiometabolic parameters on these markers, since to our knowledge, there are no studies that investigated that issue. A total of 292 participants underwent anthropometric measurements and venipuncture procedure for cardiometabolic risk factors assessment. Waist-to-height ratio (WHtR), body mass index, visceral adiposity index (VAI), and lipid accumulation product (LAP) were calculated. Principal component analysis (PCA) grouped various cardiometabolic risk parameters into different factors. This analysis was used in the subsequent binary logistic regression analysis to estimate the predictive potency of the factors towards the highest PAB and tSHG values. Our results show that triglycerides, VAI, and LAP were positively and high density lipoprotein cholesterol (HDL-c) were negatively correlated with tSHG levels and vice versa with PAB/tSHG index, respectively. On the contrary, there were no independent correlations between each cardiometabolic risk factor and PAB. PCA revealed that obesity-renal function-related factor (i.e., higher WHtR, but lower urea and creatinine) predicts both high PAB ( OR = 1.617 , 95% CI (1.204-2.171), P 〈 0.01 ) and low tSHG values ( OR = 0.443 , 95% CI (0.317-0.618), P 〈 0.001 ), while obesity-dyslipidemia-related factor (i.e., lower HDL-c and higher triglycerides, VAI, and LAP) predicts high tSHG values ( OR = 2.433 , 95% CI (1.660-3.566), P 〈 0.001 ). In conclusion, unfavorable cardiometabolic profile was associated with higher tSHG values. Further studies are needed to examine whether increased antioxidative capacity might be regarded as a compensatory mechanism due to free radicals’ harmful effects.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/6661940
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
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  • 7
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    Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C
    Walter de Gruyter GmbH ; 2019
    In:  Journal of Laboratory Medicine Vol. 43, No. 1 ( 2019-02-25), p. 29-34
    Details
    In: Journal of Laboratory Medicine, Walter de Gruyter GmbH, Vol. 43, No. 1 ( 2019-02-25), p. 29-34
    Abstract: Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p=0.011 vs. p 〈 0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (χ 2 =5.1, p=0.025, and χ 2 =11.1, p=0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p=0.066), but this significance disappeared after adjustment for age, inflammation level and duration of menopause (p=0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p=0.009), but also even after adjustment for age, inflammation level and duration of menopause (p=0.006). Conclusions RBP4 better correlates with MetS than cystatin C in postmenopausal women.
    Type of Medium: Online Resource
    ISSN: 2567-9449 , 2567-9430
    URL: Article
    DOI: 10.1515/labmed-2018-0325
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2019
    detail.hit.zdb_id: 2909042-8
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  • 8
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    Placenta-specific plasma miR518b is a potential biomarker for preeclampsia
    Elsevier BV ; 2020
    In:  Clinical Biochemistry Vol. 79 ( 2020-05), p. 28-33
    Details
    In: Clinical Biochemistry, Elsevier BV, Vol. 79 ( 2020-05), p. 28-33
    Type of Medium: Online Resource
    ISSN: 0009-9120
    URL: Article
    DOI: 10.1016/j.clinbiochem.2020.02.012
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1496880-0
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  • 9
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    Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2019
    In:  Journal of Medical Biochemistry Vol. 38, No. 4 ( 2019-03-26), p. 407-417
    Details
    In: Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 38, No. 4 ( 2019-03-26), p. 407-417
    Abstract: Alanine-aminotransferase (ALT) and uric acid cut-off levels used in non-alcoholic fatty liver disease (NAFLD) diagnosis are advised to be lowered. Due to contradictory results on the utility of both these biomarkers for NAFLD screening, we aimed to determine their cut-off levels that can be applied to Montenegrin population with the fatty liver disease. Methods A total of 771 volunteers were enrolled. A fatty liver index (FLI) score ≥60 was used as proxy of NAFLD. The receiver operating characteristic curve analysis with the area under the curve (AUC) was used to determine the cut-off values of ALT and uric acid associated with FLI ≥60. Results ALT was independent predictor of FLI in both men and women, whereas serum uric acid was its independent predictor only in women. Lower cut-off levels of ALT are associated with the increased prevalence of NAFLD [i.e., ALT was 19 IU/L (AUC=0.746, sensitivity 63%, specificity 72%, P 〈 0.001) in women and 22 IU/L (AUC=0.804, sensitivity 61%, specificity 95%, P 〈 0.001) in men]. The cut-off value for uric acid was 274 μmol/L (AUC=0.821, sensitivity 68%, specificity 82%, P 〈 0.001) in women. Conclusions Lower cut-off levels of ALT in both genders, and serum uric acid in females, can be reliable predictors of the FLI.
    Type of Medium: Online Resource
    ISSN: 1452-8266
    URL: Article
    DOI: 10.2478/jomb-2019-0001
    Language: Unknown
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2019
    detail.hit.zdb_id: 2405112-3
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  • 10
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    Malondialdehyde as an independent predictor of body mass index in adolescent girls
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2023
    In:  Journal of Medical Biochemistry Vol. 42, No. 2 ( 2023), p. 224-231
    Details
    In: Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 42, No. 2 ( 2023), p. 224-231
    Abstract: Background: Given the fact that the studies that examined oxidative stress in relation to obesity that included late adolescents are scarce and show inconclusive results we aimed to investigate a wide spectrum of nitro-oxidative stress biomarkers i.e., malondialdehyde (MDA), xanthine oxidase (XO), xanthine oxidoreductase (XOD), xanthine dehydrogenase (XDH), advanced oxidation protein products (AOPP) and nitric oxide products (NOx), as well as an antioxidative enzyme, i.e., catalase (CAT) in relation with obesity in the cohort of adolescent girls ages between 16 and 19 years old. Methods: A total of 59 teenage girls were included in this cross-sectional study. Binary logistic regression analysis was performed to examine possible associations between biochemical and nitro-oxidative stress markers and body mass index (BMI). Results: There were not significant differences between oxidative stress markers between normal weight and overweight/obese girls (i.e., AOPP, XOD, XO, XDH) and CAT, except for MDA (p 〈 0.001) and NOx (p=0.010) concentrations which were significantly higher in overweight/obese adolescent girls. Positive associations were evident between BMI and high sensitivity C-reactive protein (hsCRP) (OR=2.495), BMI and uric acid (OR=1.024) and BMI and MDA (OR=1.062). Multivariable binary regression analysis demonstrated significant independent associations of BMI and hsCRP (OR=2.150) and BMI and MDA (OR=1.105). Even 76.3% of the variation in BMI could be explained with this Model. Conclusions: Inflammation (as measured with hsCRP) and oxidative stress (as determined with MDA) independently correlated with BMI in teenage girls.
    Type of Medium: Online Resource
    ISSN: 1452-8258 , 1452-8266
    Uniform Title: Malondialdehid kao nezavisan prediktor indeksa telesne mase kod adolescentkinja
    URL: Article
    DOI: 10.5937/jomb0-39044
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2023
    detail.hit.zdb_id: 2405112-3
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