In:
Macromolecular Materials and Engineering, Wiley, Vol. 303, No. 10 ( 2018-10)
Abstract:
Multifunctional hydrogel bioadhesives have great prospects in biomedical applications, but their design still faces great challenges, such as multiple and tedious chemical modifications. However, it is difficult to integrate injectable, self‐healing, and stimulus‐responsive properties together. A facile approach based on dynamic metal‐ligand coordination chemistry between chondroitin sulfate (CS) and Fe 3+ in the design and synthesis of novel multifunctional metallohydrogel bioadhesives is reported. This CS‐based hydrogel not only has strong tissue adhesion superior to that of commercial fibrin glue, but also exhibits an excellent self‐healing ability and injectability, which are beneficial in the field of bioadhesives. Moreover, the hydrogels undergo a rapid gel–sol transformation in response to multiple external stimuli, including pH, ions, neutral molecules, and chemical redox reactions enabling the rapid removal of the bioadhesive. In addition, metallohydrogels are rapidly formed within 10 s, quick enough to promptly seal the tissue. Importantly, the multifunctional CS‐based bioadhesives are shown to exhibit good biocompatibility, thus allowing the developed materials to meet key requirements for next‐generation tissue adhesives.
Type of Medium:
Online Resource
ISSN:
1438-7492
,
1439-2054
DOI:
10.1002/mame.v303.10
DOI:
10.1002/mame.201800305
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2004372-7
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