In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 107, No. 4 ( 1984-12), p. 500-505
Abstract:
Abstract. The rate of hepatic glucose production (R a ) and peripheral utilization (R d ) was determined in 8 insulin-dependent diabetic subjects in basal state and during 40 min cycle ergometric exercise. The patients were treated with continuous sc infusion of either semisynthetic human or porcine (Actrapid®) insulin. Basal rate of glucose production was comparable during human (2.29 ± 0.19 mg/kg/min) and porcine (2.18 ± 0.12 mg/kg/min) insulin therapy. In response to exercise, R a rose 30 to 40% ( P 〈 0.05), to 2.85 ± 0.35 vs 3.18 ± 0.42 mg/kg/min, similarly during both studies. The peak rise in R d (to 3.20 ± 0.32 during human vs 3.78 ± 0.44 mg/kg/min during porcine insulin) was comparable in both groups and not significantly different from the rise in R a . Consequently, blood glucose levels remained unchanged. During the exercise tests, the metabolic conditions were stable and comparable in both studies, as indicated by similar levels of blood glucose, plasma free insulin HbA 1 , serum lipids and insulin binding to erythrocytes. In conclusion, semisynthetic human insulin is equally effective as porcine insulin in regulating glucose kinetics in the basal state and during exercise.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.1070500
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1984
detail.hit.zdb_id:
1485160-X
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