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  • 1
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    Online Resource
    渝东南地区古生界天然气成藏体系及立体勘探
    Editorial Office of Earth Science ; 2023
    In:  Earth Science-Journal of China University of Geosciences Vol. 48, No. 1 ( 2023), p. 206-
    Details
    In: Earth Science-Journal of China University of Geosciences, Editorial Office of Earth Science, Vol. 48, No. 1 ( 2023), p. 206-
    Type of Medium: Online Resource
    ISSN: 1000-2383
    URL: Article
    DOI: 10.3799/dqkx.2022.440
    Language: Unknown
    Publisher: Editorial Office of Earth Science
    Publication Date: 2023
    SSG: 13
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  • 2
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    The Predominance of the Apoplasmic Phloem-unloading Pathway is Interrupted by a Symplasmic Pathway During Chinese Jujube Fruit Development
    Oxford University Press (OUP) ; 2010
    In:  Plant and Cell Physiology Vol. 51, No. 6 ( 2010-6), p. 1007-1018
    Details
    In: Plant and Cell Physiology, Oxford University Press (OUP), Vol. 51, No. 6 ( 2010-6), p. 1007-1018
    Type of Medium: Online Resource
    ISSN: 1471-9053 , 0032-0781
    URL: Article
    DOI: 10.1093/pcp/pcq054
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2010
    detail.hit.zdb_id: 2020758-X
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  • 3
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    DataSheet1.docx
    Frontiers Media SA ; 2023
    In:  Frontiers in Pharmacology Vol. 14 ( 2023-9-11)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 14 ( 2023-9-11)
    Abstract: Purpose: To comprehensively reassess the efficacy and safety of different concentrations of atropine for retarding myopia progression and seek the most appropriate therapeutic concentration for clinical practice. Methods: We searched PubMed, Cochrane Library, Embase, Chinese Science and Technology Periodicals (VIP) and China National Knowledege Infrastructure (CNKI) from their inception to 23 March 2023, to obtain eligible randomized controlled trials (RCTs) and cohort studies that had atropine in at least one treatment arm and placebo/no intervention in another arm. We evaluated the risk of bias of the RCTs according to the recommendations of the Cochrane Collaboration for RCTs and quality of cohort studies by the Newcastle‒Ottawa Scale. Weighted mean difference (WMD), 95% confidence interval were calculated for meta-analysis. All data analyses were performed using Review Manager 5.3, STATA 12.0 and SPSS 26.0 software. Results: A total of 44 studies were included in the meta-analysis. Weighted mean difference (WMD) were 0.73 diopters (D), 0.65 D, 0.35 D per year in refraction progression ( χ 2 = 14.63, I 2 = 86.3%; p & lt; 0.001) and −0.26 mm, −0.37 mm, −0.11 mm per year in axial length progression ( χ 2 = 5.80, I 2 = 65.5%; p = 0.06) for high (0.5%–1%), moderate (0.1%–0.25%), and low (0.005%–0.05%) dose atropine groups, respectively. Logarithmic dose‒response correlations were found between atropine and their effect on change of refraction, axial length, accommodation and photopic pupil diameter. Through these curves, we found that atropine with concentrations ≤0.05% atropine resulted in a residual value of accommodation of more than 5 D and an increase in pupil diameter no more than 3 mm. Higher doses of atropine resulted in a higher incidence of adverse effects, of which the incidence of photophobia was dose-dependent ( r = 0.477, p = 0.029). Conclusion: Both the efficacy and risk of adverse events for atropine treatment of myopia were mostly dose dependent. Comprehensively considered the myopia control effect and safety of each dose, 0.05% may be the best concentration of atropine to control myopia progression at present, at which myopia is better controlled and the side effects are tolerable. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/#recordDetails , CRD42022377705.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    URL: Article
    DOI: 10.3389/fphar.2023.1227787
    DOI: 10.3389/fphar.2023.1227787.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 4
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    Table_9.xlsx
    Frontiers Media SA ; 2023
    In:  Frontiers in Plant Science Vol. 14 ( 2023-6-14)
    Details
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 14 ( 2023-6-14)
    Abstract: Apricot fruits are edible and serve as a source of medicinal compounds. Flavonols are important plant secondary metabolites that have antioxidant and antitumor effects and may promote cardiovascular health. Methods The flavonoid content in three stages of the ‘Kuijin’ and the ‘Katy’ was observed, followed by the combination of metabolome and transcriptome analysis to explore the metabolic basis of flavonol synthesis. Results The differences in the metabolite contents between stages (of the same cultivar) and between cultivars (at the same stage) revealed decreases in the flavonoid content as fruits developed (i.e., from 0.28 mg/g to 0.12 mg/g in ‘Kuijin’ and from 0.23 mg/g to 0.05 mg/g in ‘Katy’). To decipher the regulation of flavonol synthesis in apricot (Prunus armeniaca L.), the metabolomes and transcriptomes of fruit pulp at three developmental stages of ‘Kuijin’ and the ‘Katy’ were analyzed. A total of 572 metabolites were detected in ‘Kuijin’ and the ‘Katy’ pulp, including 111 flavonoids. The higher flavonol content young ‘Kuijin’ fruits at 42 days after full bloom is mainly due to 10 types of flavonols. Three pairs of significant differences in flavonol content were identified. From these three comparison groups, three structural genes were strongly correlated with the levels of 10 types of flavonols (Pearson correlation coefficients & gt; 0.8, p value & lt; 0.05), including PARG09190, PARG15135, and PARG17939. The weighted gene co-expression network analysis showed that the turquoise module genes were highly correlated with flavonol contents (P & lt; 0.01). There were 4897 genes in this module. Out of 4897 genes, 28 transcription factors are associated with 3 structural genes based on weight value. Two of the transcription factors are not only associated with PARG09190 but also with PARG15135, indicating their critical importance in the flavonols biosynthesis. The two TFs are PARG27864 and PARG10875. Discussion These findings provide new insights into the biosynthesis of flavonols and may explain the significant differences in flavonoid content between the ‘Kuijin’ and the ‘Katy’ cultivars. Moreover, it will aid in genetic improvement to enhance the nutritional and health value of apricots.
    Type of Medium: Online Resource
    ISSN: 1664-462X
    URL: Article
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    DOI: 10.3389/fpls.2023.1187551
    DOI: 10.3389/fpls.2023.1187551.s001
    DOI: 10.3389/fpls.2023.1187551.s002
    DOI: 10.3389/fpls.2023.1187551.s003
    DOI: 10.3389/fpls.2023.1187551.s004
    DOI: 10.3389/fpls.2023.1187551.s005
    DOI: 10.3389/fpls.2023.1187551.s006
    DOI: 10.3389/fpls.2023.1187551.s007
    DOI: 10.3389/fpls.2023.1187551.s008
    DOI: 10.3389/fpls.2023.1187551.s009
    DOI: 10.3389/fpls.2023.1187551.s010
    DOI: 10.3389/fpls.2023.1187551.s011
    DOI: 10.3389/fpls.2023.1187551.s012
    DOI: 10.3389/fpls.2023.1187551.s013
    DOI: 10.3389/fpls.2023.1187551.s014
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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  • 5
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    A high-quality assembled genome of a representative peach landrace, ‘Feichenghongli’, and analysis of distinct late florescence and narrow leaf traits
    Springer Science and Business Media LLC ; 2023
    In:  BMC Plant Biology Vol. 23, No. 1 ( 2023-04-29)
    Details
    In: BMC Plant Biology, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-04-29)
    Abstract: Peach ( Prunus persica L. Batsch) is one of the most popular fruits worldwide. Although the reference genome of ‘Lovell’ peach has been released, the diversity of genome-level variations cannot be explored with one genome. To detect these variations, it is necessary to assemble more genomes. Results We sequenced and de novo assembled the genome of ‘Feichenghongli’ (FCHL), a representative landrace with strict self-pollination, which maintained the homozygosity of the genome as much as possible. The chromosome-level genome of FCHL was 239.06 Mb in size with a contig N50 of 26.93 Mb and only 4 gaps at the scaffold level. The alignment of the FCHL genome with the reference ‘Lovell’ genome enabled the identification of 432535 SNPs, 101244 insertions and deletions, and 7299 structural variants. Gene family analysis showed that the expanded genes in FCHL were enriched in sesquiterpenoids and triterpenoid biosynthesis. RNA-seq analyses were carried out to investigate the two distinct traits of late florescence and narrow leaves. Two key genes, PpDAM4 and PpAGL31 , were identified candidates for the control of flower bud dormancy, and an F-box gene, PpFBX92 , was identified as a good candidate gene in the regulation of leaf size. Conclusions The assembled high-quality genome could deepen our understanding of variations among diverse genomes and provide valuable information for identifying functional genes and improving the molecular breeding process.
    Type of Medium: Online Resource
    ISSN: 1471-2229
    URL: Article
    DOI: 10.1186/s12870-023-04242-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2059868-3
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  • 6
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    Genome-Wide Identification and Expression Profiling Reveal the Potential Functions of the SWEET Gene Family during the Sink Organ Development Period in Apple (Malus × domestica Borkh.)
    MDPI AG ; 2022
    In:  Agronomy Vol. 12, No. 8 ( 2022-07-25), p. 1747-
    Details
    In: Agronomy, MDPI AG, Vol. 12, No. 8 ( 2022-07-25), p. 1747-
    Abstract: Sugars Will Eventually be Exported Transporters (SWEETs) play important roles during plant growth and development. Bioinformatics revealed 27 SWEET genes in the apple (Malus × domestica Borkh.) genome and classified them into four clades. These genes are unevenly located on 12 chromosomes, and 8 tandem-repeat genes and 18 fragment-repeat genes are present in the MdSWEET family. PlantCARE-based prediction of cis-acting elements of the MdSWEET promoter suggested that most MdSWEETs may be expressed specifically in the phloem and respond to hormones and stresses. qRT-PCR results showed that expression patterns of MdSWEETs displayed pronounced differences in different tissues/organs and different stages of apple fruit development. MdSWEET5, MdSWEET7, and MdSWEET21 were strongly expressed in mature leaves, MdSWEET2, MdSWEET12, MdSWEET13, MdSWEET14, MdSWEET17, and MdSWEET22 were highly expressed in peduncles, MdSWEET4 was highly expressed in young leaves, MdSWEET3, MdSWEET11, MdSWEET15, MdSWEET16, MdSWEET19, MdSWEET24, and MdSWEET25 were highly expressed in different parts of flowers, and MdSWEET1, MdSWEET6, MdSWEET8, MdSWEET9, MdSWEET10, MdSWEET18, MdSWEET20, MdSWEET23, and MdSWEET26 were strongly expressed in fruits. MdSWEET8 showed higher expression in the early stage of fruit development, MdSWEET1, MdSWEET10, and MdSWEET27 were highly expressed in the middle stage of fruit development, and MdSWEET6, MdSWEET9, MdSWEET18, MdSWEET20, MdSWEET23, and MdSWEET26 were sharply upregulated in the late developmental period. Our study could facilitate SWEET functional analysis in different tissue/organs and in sugar accumulation throughout the development and ripening of apple fruits. These findings provide potential opportunities to increase sugar accumulation in fruit, thereby improving fruit quality and yield.
    Type of Medium: Online Resource
    ISSN: 2073-4395
    URL: Article
    DOI: 10.3390/agronomy12081747
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2607043-1
    SSG: 23
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  • 7
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    Predominantly symplastic phloem unloading of photosynthates maintains efficient starch accumulation in the cassava storage roots (Manihot esculenta Crantz)
    Springer Science and Business Media LLC ; 2021
    In:  BMC Plant Biology Vol. 21, No. 1 ( 2021-12)
    Details
    In: BMC Plant Biology, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Abstract: Cassava ( Manihot esculenta Crantz) efficiently accumulates starch in its storage roots. However, how photosynthates are transported from the leaves to the phloem (especially how they are unloaded into parenchymal cells of storage roots) remains unclear. Results Here, we investigated the sucrose unloading pattern and its impact on cassava storage root development using microstructural and physiological analyses, namely, carboxyfluorescein (CF) and C 14 isotope tracing. The expression profiling of genes involved in symplastic and apoplastic transport was performed, which included enzyme activity, protein gel blot analysis, and transcriptome sequencing analyses. These finding showed that carbohydrates are transported mainly in the form of sucrose, and more than 54.6% was present in the stem phloem. Sucrose was predominantly unloaded symplastically from the phloem into storage roots; in addition, there was a shift from apoplastic to symplastic unloading accompanied by the onset of root swelling. Statistical data on the microstructures indicated an enrichment of plasmodesmata within sieve, companion, and parenchyma cells in the developing storage roots of a cultivar but not in a wild ancestor. Tracing tests with CF verified the existence of a symplastic channel, and [ 14 C] Suc demonstrated that sucrose could rapidly diffuse into root parenchyma cells from phloem cells. The relatively high expression of genes encoding sucrose synthase and associated proteins appeared in the middle and late stages of storage roots but not in primary fibrous roots, or secondary fibrous roots. The inverse expression pattern of sucrose transporters, cell wall acid invertase, and soluble acid invertase in these corresponding organs supported the presence of a symplastic sucrose unloading pathway. The transcription profile of genes involved in symplastic unloading and their significantly positive correlation with the starch yield at the population level confirmed that symplastic sucrose transport is vitally important in the development of cassava storage roots. Conclusions In this study, we revealed that the cassava storage root phloem sucrose unloading pattern was predominantly a symplastic unloading pattern. This pattern is essential for efficient starch accumulation in high-yielding varieties compared with low-yielding wild ancestors.
    Type of Medium: Online Resource
    ISSN: 1471-2229
    URL: Article
    DOI: 10.1186/s12870-021-03088-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2059868-3
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  • 8
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    Patient safety education for undergraduate medical students: a systematic review
    Springer Science and Business Media LLC ; 2011
    In:  BMC Medical Education Vol. 11, No. 1 ( 2011-12)
    Details
    In: BMC Medical Education, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2011-12)
    Abstract: To reduce harm caused by health care is a global priority. Medical students should be able to recognize unsafe conditions, systematically report errors and near misses, investigate and improve such systems with a thorough understanding of human fallibility, and disclose errors to patients. Incorporating the knowledge of how to do this into the medical student curriculum is an urgent necessity. This paper aims to systematically review the literature about patient safety education for undergraduate medical students in terms of its content, teaching strategies, faculty availability and resources provided so as to identify evidence on how to promote patient safety in the curriculum for medical schools. This paper includes a perspective from the faculty of a medical school, a major hospital and an Evidence Based Medicine Centre in Sichuan Province, China. Methods We searched MEDLINE, ERIC, Academic Source Premier(ASP), EMBASE and three Chinese Databases (Chinese Biomedical Literature Database, CBM; China National Knowledge Infrastructure, CNKI; Wangfang Data) from 1980 to Dec. 2009. The pre-specified form of inclusion and exclusion criteria were developed for literature screening. The quality of included studies was assessed using Darcy Reed and Gemma Flores-Mateo criteria. Two reviewers selected the studies, undertook quality assessment, and data extraction independently. Differing opinions were resolved by consensus or with help from the third person. Results This was a descriptive study of a total of seven studies that met the selection criteria. There were no relevant Chinese studies to be included. Only one study included patient safety education in the medical curriculum and the remaining studies integrated patient safety into clinical rotations or medical clerkships. Seven studies were of a pre and post study design, of which there was only one controlled study. There was considerable variation in relation to contents, teaching strategies, faculty knowledge and background in patient safety, other resources and outcome evaluation in these reports. The outcomes from including patient safety in the curriculum as measured by medical students' knowledge, skills, and attitudes varied between the studies. Conclusions There are only a few relevant published studies on the inclusion of patient safety education into the undergraduate curriculum in medical schools either as a selective course, a lecture program, or by being integrated into the existing curriculum even in developed countries with advanced health and education systems. The integration of patient safety education into the existing curriculum in medical schools internationally, provides significant challenges.
    Type of Medium: Online Resource
    ISSN: 1472-6920
    URL: Article
    DOI: 10.1186/1472-6920-11-33
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2011
    detail.hit.zdb_id: 2044473-4
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  • 9
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    Enrichment mechanism and resource potential of shale-type helium: A case study of Wufeng Formation-Longmaxi Formation in Sichuan Basin
    Springer Science and Business Media LLC ; 2023
    In:  Science China Earth Sciences Vol. 66, No. 6 ( 2023-06), p. 1279-1288
    Details
    In: Science China Earth Sciences, Springer Science and Business Media LLC, Vol. 66, No. 6 ( 2023-06), p. 1279-1288
    Type of Medium: Online Resource
    ISSN: 1674-7313 , 1869-1897
    URL: Article
    DOI: 10.1007/s11430-022-1045-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2546528-4
    SSG: 6,25
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  • 10
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    Enrichment characteristics and exploration directions of deep shale gas of Ordovician–Silurian in the Sichuan Basin and its surrounding areas, China
    Elsevier BV ; 2022
    In:  Petroleum Exploration and Development Vol. 49, No. 4 ( 2022-08), p. 744-757
    Details
    In: Petroleum Exploration and Development, Elsevier BV, Vol. 49, No. 4 ( 2022-08), p. 744-757
    Type of Medium: Online Resource
    ISSN: 1876-3804
    URL: Article
    DOI: 10.1016/S1876-3804(22)60307-0
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2471051-9
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