In:
Journal of Chemical Research, SAGE Publications, Vol. 45, No. 11-12 ( 2021-11), p. 992-997
Abstract:
Six pyrophosphate analogues are prepared from zerumbone, murrayafoline A, acridone, and 4-hydroxycoumarin via 1,3-dipolar cycloaddition reactions. Their in vitro cytotoxic activity is evaluated against HepG2, LU-1, and HeLa cancer cell lines. Among them, diisopropyl ((ethoxy((4-((1-methoxy-3-methyl-9 H-carbazol-9-yl)methyl)-1 H-1,2,3-triazol-1-yl)methyl)phosphoryl)methyl)phosphonate (6a) and diisopropyl ((ethoxy((4-(((3-methyl-9 H-carbazol-1-yl)oxy)methyl)-1 H-1,2,3-triazol-1-yl)methyl)phosphoryl)methyl)phosphonate (6b) are found to show activity against HepG2, LU-1, and HeLa cancer cell lines, with IC 50 values ranging from 7.31 to 17.88 μM.
Type of Medium:
Online Resource
ISSN:
1747-5198
,
2047-6507
DOI:
10.1177/17475198211043439
Language:
English
Publisher:
SAGE Publications
Publication Date:
2021
detail.hit.zdb_id:
3010810-X
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