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  • 1
    Online Resource
    Online Resource
    Study on molecular subtypes and correlation between molecular subtypes and histopathological features in invasive breast cancer
    Hue University of Medicine and Pharmacy ; 2022
    In:  Journal of Medicine and Pharmacy
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Background: To determine the molecular subtypes and correlation between molecular subtypes and histopathological features in breast cancer in Vietnam and Italy. Material and method: 88 patients with invasive breast carcinoma (BC) in both Hue Central Hospital and Hue University Hospital in Vietnam during 1 year from April 2016 to April 2017 as well as 235 patients from the same category of women in Sassari University Hospital, Italy during the year 2016 were collected. All patients were examined for immunohistochemistry (IHC) with four markers ER, PR, HER2, and Ki67. The immunofluorescence in situ hybridization (FISH) test was applied for cases with HER2 (2+)/ IHC. Results: Breast cancer in Vietnam had the highest Luminal B (LB) rate, at 37.5%, followed by HER2 enrich (22.7%) and triple-negative breast cancer accounting for 21.6%. Luminal A (LA) accountd for the lowest proportion (18.2%). In contrast, breast cancer in Italy has the highest rate of Luminal A (54%), LB accounted for 34.5%, triple-negative occupied 10.6% and HER2 enrichment has a very low rate (0.9%). There was a statistically significant correlation between molecular subtypes and pathological features such as histologic grade, axillary lymph node, and stage of disease in both Vietnamese and Italian groups (p 〈 0.005). Most breast cancers in Vietnam and Italy belong to the Luminal A with low histologic grade, early-stage disease, and no metastasis. No statistically significant association was found between molecular subtypes and tumor size in the Vietnamese breast cancer group. By contrast, this association was statistically significant with p 〈 0.05 in Italy. Conclusion: There is a significant difference in the molecular subtypes and the correlation between molecular subtypes and histopathological features between Vietnamese and Italian breast cancers. The two more common subtypes in Vietnam are LB and HER2, while in Italy they are LA and LB. The rate of HER2 subtypes in Vietnam is much higher than in Italy Key words: Invasive breast carcinoma, molecular subtype, Vietnam, Italy
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2022.5.25
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    TO EVALUATE THE QUALITY OF CRYOPRESERVED GAMMA-STERILIZED DOG SKULL AT TISSUE CRYOPRESERVATION UNIT - HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL
    Hue University of Medicine and Pharmacy ; 2019
    In:  Journal of Medicine and Pharmacy
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Objective: To evaluate the effect of gamma sterilization and the changes in the durability and the histological structure of cryopreserved gamma-sterilized dog skull. Subjects and methods: 50 dog skull fragments had the same size (4 x 4 cm), which were taken at parieto-frontal region, symmetrically through the midline of the skull were divided into two lots. Evident lot consisting of 50 fragments were just cryopreserved, not irradiated by gamma rays. Experimental lot which composed of 50 fragments were cryopreserved and exposed to 25 kGy of gamma radiation. Afterwards, evaluating the changes in the durability, microscopic structure an d the effectiveness of sterilization on the dog skull after being cryopreserved at -85 0C in 3 months and exposed a gamma sterilization. Results: The durability was decreased of 8.28% compared with the lot of dog skull just cryopreserved at -85 0C and not exposed a gamma sterilization. On histological structure, no difference was found between the two lots and there was no structural change in the irradiated dog skull. All gamma-sterilized dog skull fragments were negative with bacteria culture test. The gamma ray had the ability to kill bacteria completely in the type of bacteria commonly infected tissue. Conclusion: After being cryopreserved at -85 0C in 3 months and exposed a gamma sterilization dose of 25 KGy, the durability of dog skull was insignificantly decreased and the microscopic structure was not changed. All irradiated dog skull fragments were negative with bacteria culture test. Key words: dog skull, gamma, durability, irradiated
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2019.4.4
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2019
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  • 3
    Online Resource
    Online Resource
    THE EFFECT OF GAMMA STERILIZATION AND ITS EFFECT ON MICROSCOPIC STRUCTURE OF DEEP FROZEN DOG SKULL
    Hue University of Medicine and Pharmacy ; 2018
    In:  Journal of Medicine and Pharmacy
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Objective: To evaluate the effect of gamma sterilization and its effect on microscopic structure of deeply frozen dog skull. Subjects and methods: 50 pairs of dog skull fragments have the same size,which were taken symmetrically through the midline of the skull, were divided into two lots. Evident lot consisting of 50 pieces are just deeply frozen, not irradicated. Experimental lot which was composed of 50 pieces were deeply frozen and exposed to 25kGy of gamma radiation. Afterwards, to evaluate the effect of gamma sterilization and compare the alter of bone matrix between lot groups. Results: After gamma irradiation, all dog skull fragments were negative with bacteriological examination. In microscopic scale, no difference was found between the two lots and there was no structural change in the irradiated fragments of all dog skull. Conclusion: Gamma irradiation with 25 kGy: (i) It has the ability to kill bacteria completely in the type of bacteria commonly infected tissue. (ii) It does not alter the structure of dog skull in microstructures. Key words: dog skull, gamma, sterilize
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2018.2.6
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2018
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  • 4
    Online Resource
    Online Resource
    Bimetallic Al/Fe Metal-Organic Framework for highly efficient photo-Fenton degradation of rhodamine B under visible light irradiation
    Elsevier BV ; 2020
    In:  Materials Letters Vol. 279 ( 2020-11), p. 128482-
    Details
    In: Materials Letters, Elsevier BV, Vol. 279 ( 2020-11), p. 128482-
    Type of Medium: Online Resource
    ISSN: 0167-577X
    URL: Article
    DOI: 10.1016/j.matlet.2020.128482
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1491964-3
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  • 5
    Online Resource
    Online Resource
    Correlation between HER2 Expression and Clinicopathological Features of Breast Cancer: A Cross- Sectional Study in Vietnam
    EpiSmart Science Vector Ltd ; 2020
    In:  Asian Pacific Journal of Cancer Prevention Vol. 21, No. 4 ( 2020-04-01), p. 1135-1142
    Details
    In: Asian Pacific Journal of Cancer Prevention, EpiSmart Science Vector Ltd, Vol. 21, No. 4 ( 2020-04-01), p. 1135-1142
    Type of Medium: Online Resource
    ISSN: 2476-762X
    URL: Article
    DOI: 10.31557/APJCP.2020.21.4.1135
    Language: English
    Publisher: EpiSmart Science Vector Ltd
    Publication Date: 2020
    detail.hit.zdb_id: 2218955-5
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  • 6
    Online Resource
    Online Resource
    Pathological characteristics and bcl11a gene analysis in molecular subtypes of breast cancer
    Hue University of Medicine and Pharmacy ; 2020
    In:  Journal of Medicine and Pharmacy
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Background: Breast cancer is the most frequent cause of cancer-related deaths among women worldwide. Molecular classification and the analysis of gene expression have been playing a pivotal role in deciding treatment therapy. The aim of study was to identify molecular surrogate subtypes of breast cancer by immunohistochemistry and Dual In Situ Hybridization, analysis of BCL11A gene expression was performed in molecular subtypes by RT-PCR and assessed the correlation between molecular subtypes and clinic-pathological characteristics. Materials and methods: Cross-sectional description study, tumor specimens from 138 patients were stained with Hematoxylin and Eosin to diagnosis, histopathological classification, stained with immunohistochemical markers ER, PR, HER2, Ki67 and Dual In Situ Hybridization (DISH) to classify molecular subtypes breast cancer. In which, RNA of 20 samples were extraction and performed by RT-PCR. Results: A significant association between breast carcinoma subtypes with histologic type (p=0.022) and grade (p=0.021). BCL11A was significantly down regulated in all molecular breast cancer subtypes especially in triple negative group. Conclusion: This study may help to understand pathological characteristics and the gene expression of difference breast cancer subtypes, contributing to the successful identification of therapeutic targets for breast cancer, especially triple negative group. Key words: Invasive breast carcinoma, molecular subtypes, histologic grade, Dual In Situ Hybridization (DISH), qRT-PCR
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2020.4.3
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2020
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  • 7
    Online Resource
    Online Resource
    Synthesis of diphenyl sulfide from iodobenzene and thiophenol using Metal-Organic Framework Cu2(NDC)2(DABCO) as an efficient heterogeneous catalyst
    Hanoi University of Science and Technology ; 2020
    In:  Vietnam Journal of Catalysis and Adsorption Vol. 9, No. 4 ( 2020-12-31), p. 70-76
    Details
    In: Vietnam Journal of Catalysis and Adsorption, Hanoi University of Science and Technology, Vol. 9, No. 4 ( 2020-12-31), p. 70-76
    Abstract: A metal-organic framework Cu2(NDC)2(DABCO) was synthesized from copper nitrate trihydrate, 2,6-Napthalenedicarboxylic acid (H2NDC), and 1,4-diazabicyclo[2.2.2]octane (DABCO) by solvothermal method. Its physicochemical properties were confirmed by several techniques such as X-ray powder diffraction (PXRD), Fourier transform infrared (FT-IR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Cu2(NDC)2(DABCO) appeared as well-shaped crystals. To get diphenyl sulfide as desired product from the C-S cross coupling reaction of iodobenzene and thiophenol, the Cu2(NDC)2(DABCO) was used as heterogeneous catalyst  in the presence of LiO-tBu as base. The results showed that the transformation could proceed with more than 93% reaction conversion being obtained after 6 h at 120 oC when using 5 mol% Cu2(NDC)2(DABCO) catalyst in the presence of LiO-tBu. The solid catalyst could be recovered and reused five times without a significant degradation in catalytic activity. The coupling reaction could only proceed to achieve major product in the presence of the Cu2(NDC)2(DABCO catalyst.
    Type of Medium: Online Resource
    ISSN: 0866-7411
    URL: Article
    DOI: 10.51316/jca.2020.072
    Language: Unknown
    Publisher: Hanoi University of Science and Technology
    Publication Date: 2020
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  • 8
    Online Resource
    Online Resource
    Nghiên cứu tận thu hạt từ tính từ băng từ (cassette) phế thải
    Truong Dai hoc Nguyen Tat Thanh ; 2024
    In:  Journal of Science and Technology Vol. 1, No. 2 ( 2024-01-24)
    Details
    In: Journal of Science and Technology, Truong Dai hoc Nguyen Tat Thanh, Vol. 1, No. 2 ( 2024-01-24)
    Abstract: Trong nghiên cứu này, quá trình tận thu bột từ tính từ nguồn nguyên liệu là băng cassette phế thải bằng cách sử dụng dung môi hữu cơ thông dụng rẻ tiền đã được thực hiện. Nghiên cứu đã khảo sát nhiều thông số để tìm ra điều kiện thuận lợi cho quá trình tận thu bột từ tính như: các loại dung môi khác nhau, thời gian ngâm dung môi, nhiệt độ. Kết quả tốt nhất có thể đạt được là 1,5312g bột từ tính trên 3,3000g nguyên liệu, khi khuấy nguyên liệu trong dung môi acetone ở điều kiện đun sôi hoàn lưu trong thời gian 4 giờ. Ngoài ra, nghiên cứu còn tiến hành phân tích một số đặc tính cơ bản của bột từ thu được bằng các phương pháp hiện đại như: phương pháp phổ nhiễu xạ tia X (XRD), phân tích nhiệt trọng lượng (TGA), kính hiển vi điện tử truyền qua (TEM), khảo sát đường cong từ trễ bằng phương pháp từ kế mẫu rung (VSM-Vibrating Sample Magnetometer).
    Type of Medium: Online Resource
    ISSN: 2615-9015 , 2615-9015
    URL: Article
    DOI: 10.55401/r4m7tj88
    Language: English
    Publisher: Truong Dai hoc Nguyen Tat Thanh
    Publication Date: 2024
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  • 9
    Online Resource
    Online Resource
    Preparation of Curcumin Nanosuspension with Gum Arabic as a Natural Stabilizer: Process Optimization and Product Characterization
    MDPI AG ; 2020
    In:  Processes Vol. 8, No. 8 ( 2020-08-12), p. 970-
    Details
    In: Processes, MDPI AG, Vol. 8, No. 8 ( 2020-08-12), p. 970-
    Abstract: Low aqueous solubility and poor bioavailability of curcumin have limited its application in various fields. One approach to address this issue is to formulate a nanosuspension that incorporates curcumin, which has been previously shown to exhibit remarkably improved solubility in comparison with that of a bare compound. In this study, the preparation process of curcumin nanosuspension was optimized with a median particle size as the outcome. Gum arabic was used as a natural polymeric surfactant and the suspension was formulated using high speed homogenization. Optimization results, realized via a response surface methodology, showed that a minimum median particle size (8.524 µm) could be attained under the following conditions: curcumin:gum arabic ratio of 1:6 g/g; homogenization speed of 8300 rpm and homogenization time of 40 min. Under these conditions, the particle size of obtained suspension was shown to be consistent for around seven days without major aggregation. The homogenization process could be scaled up to five times in terms of suspension volume. TEM also showed that curcumin nanoparticles had a nearly spherical shape and homogeneous structure with a size range of 40–80 nm.
    Type of Medium: Online Resource
    ISSN: 2227-9717
    URL: Article
    DOI: 10.3390/pr8080970
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2720994-5
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  • 10
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    Online Resource
    Color and composition of beauty products formulated with lemongrass essential oil: Cosmetics formulation with lemongrass essential oil
    Walter de Gruyter GmbH ; 2021
    In:  Open Chemistry Vol. 19, No. 1 ( 2021-07-13), p. 820-829
    Details
    In: Open Chemistry, Walter de Gruyter GmbH, Vol. 19, No. 1 ( 2021-07-13), p. 820-829
    Abstract: Diversification of products that are derived from essential oils carries important implications in reducing agricultural waste and promoting the medicinal materials industry. In this study, we formulated a shampoo and a body wash product incorporated with lemongrass ( Cymbopogon citratus ) essential oils (LEOs) and evaluated their color stability and the LEO compositional change. We first determined the color change and chemical composition of bare LEO under different storage conditions. Afterward, the washing product base was formulated, and its formulation process was optimized to minimize the color change by varying a wide range of parameters including pH, the inclusion of preservatives and antioxidants, LEO/antioxidant ratio, and emulsification temperature. The base product was then used in body wash and shampoo formulation following our previously reported procedure. The results indicated that direct incorporation of the LEO into the cosmetic products resulted in better color stability and citral retention in comparison with emulsion formation. In addition, shampoo and body wash products showed no detectible presence of compounds resulting from citral decomposition such as 3,7-dimethyl-1,3,6-octatriene, p -mentha-1,5-dien-8-ol, and p -cymene-8-ol. The current findings are expected to aid in diversifying LEO-derived commodities and justifying scalability of the cosmetics production process with a focus on the incorporation of naturally derived ingredients.
    Type of Medium: Online Resource
    ISSN: 2391-5420
    URL: Article
    DOI: 10.1515/chem-2021-0066
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2021
    detail.hit.zdb_id: 2825411-9
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