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  • 1
    Online Resource
    Online Resource
    Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study
    Elsevier BV ; 2018
    In:  The Lancet Neurology Vol. 17, No. 8 ( 2018-08), p. 699-708
    Details
    In: The Lancet Neurology, Elsevier BV, Vol. 17, No. 8 ( 2018-08), p. 699-708
    Type of Medium: Online Resource
    ISSN: 1474-4422
    URL: Article
    DOI: 10.1016/S1474-4422(18)30215-1
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
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  • 2
    Online Resource
    Online Resource
    The Effect of Alkaloid Extracted from Huperzia Phlegmaria on Cognitive Deficits Scopolamine-Induced in Mice
    Bentham Science Publishers Ltd. ; 2021
    In:  Current Bioactive Compounds Vol. 17, No. 3 ( 2021-05-06), p. 267-278
    Details
    In: Current Bioactive Compounds, Bentham Science Publishers Ltd., Vol. 17, No. 3 ( 2021-05-06), p. 267-278
    Abstract: Huperzia phlegmaria has been used for the treatment of neurological disorder. Alkaloids are main bioactive compounds found in Huperzia phlegmaria. We aimed to investigate the acetylcholinesterase (AChE) inhibitory activity in vitro of Huperzia phlegmaria alkaloid extract (HpAE) and protective effects on mice which were induced cognitive deficits by scopolamine. Methods: AChE inhibitory activity and kinetic inhibition mechanism was investigated by Ellman's assay. Mice were administrated orally HpAE (30 mg/kg and 60 mg/kg) for fourteen days, and injected scopolamine at a dose of 1 mg/kg intraperitoneally for four days to induce cognitive impairment. The Y-maze and the Morris water maze were used for evaluating the memory behaviors. Acetylcholine (ACh) levels and AChE activity were measured in brain tissue. Glutathione peroxidase (GPx), superoxide dismutase (SOD) activities, and malondialdehyde (MDA) groups were also evaluated in the mouse brain tissues. Results: Our data showed that HpAE had a strong AChE inhibitory activity with an IC 50 value of 5.12 ± 0.48 μg/mL in a concentration-dependent manner. Kinetic inhibition analysis demonstrated that HpAE inhibited AChE followed the mixed inhibition type with Ki (representing the affinity of the enzyme and inhibitor) was 4.37 ± 0.35 μg/mL. Scopolamine induced the cognitive impairment in the Morris Water Maze and Y-maze test along with reduced brain levels of ACh and antioxidant enzyme and increased AChE activity in mouse brain tissues. Treatment with HpAE at both doses (30 mg/kg and 60 mg/kg) decreased the SCP-induced cognitive impairment in both behavioral tests along with decreased acetylcholinesterase activity and MDA level, and increased ACh level and antioxidant enzyme in mouse brain tissues. Conclusion: Our results suggested that the HpAE at both dose (30 mg/kg and 60 mg/kg) may be used for prevent and treatment of Alzheimer’s disease.
    Type of Medium: Online Resource
    ISSN: 1573-4072
    URL: Article
    DOI: 10.2174/1573407216999200520082046
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Development of a Spatial Decision Support System for Real-Time Flood Early Warning in the Vu Gia-Thu Bon River Basin, Quang Nam Province, Vietnam
    MDPI AG ; 2020
    In:  Sensors Vol. 20, No. 6 ( 2020-03-17), p. 1667-
    Details
    In: Sensors, MDPI AG, Vol. 20, No. 6 ( 2020-03-17), p. 1667-
    Abstract: Vu Gia-Thu Bon (VGTB) river basin is an area where flash flood and heavy flood events occur frequently, negatively impacting the local community and socio-economic development of Quang Nam Province. In recent years, structural and non–structural solutions have been implemented to mitigate damages due to floods. However, under the impact of climate change, natural disasters continue to happen unpredictably day by day. It is, therefore, necessary to develop a spatial decision support system for real-time flood warnings in the VGTB river basin, which will support in ensuring the area’s socio-economic development. The main purpose of this study is to develop an online flood warning system in real-time based on Internet-of-Things (IoT) technologies, GIS, telecommunications, and modeling (Soil and Water Assessment Tool (SWAT) and Hydrologic Engineering Center’s River Analysis System (HEC–RAS)) in order to support the local community in the vulnerable downstream areas in the event of heavy rainfall upstream. The structure of the designed system consists of these following components: (1) real-time hydro-meteorological monitoring network, (2) IoT communication infrastructure (Global System for Mobile Communications (GSM), General Packet Radio Service (GPRS), wireless networks), (3) database management system (bio-physical, socio-economic, hydro-meteorological, and inundation), (4) simulating and predicting model (SWAT, HEC–RAS), (5) automated simulating and predicting module, (6) flood warning module via short message service (SMS), (7) WebGIS, application for providing and managing hydro-meteorological and inundation data, and (8) users (citizens and government officers). The entire operating processes of the flood warning system (i.e., hydro-meteorological data collecting, transferring, updating, processing, running SWAT and HEC–RAS, visualizing) are automated. A complete flood warning system for the VGTB river basin has been developed as an outcome of this study, which enables the prediction of flood events 5 h in advance and with high accuracy of 80%.
    Type of Medium: Online Resource
    ISSN: 1424-8220
    URL: Article
    DOI: 10.3390/s20061667
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2052857-7
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  • 4
    Online Resource
    Online Resource
    Neuropsychological performance before and after partial or complete insulectomy in patients with epilepsy
    Elsevier BV ; 2015
    In:  Epilepsy & Behavior Vol. 43 ( 2015-02), p. 53-60
    Details
    In: Epilepsy & Behavior, Elsevier BV, Vol. 43 ( 2015-02), p. 53-60
    Type of Medium: Online Resource
    ISSN: 1525-5050
    URL: Article
    DOI: 10.1016/j.yebeh.2014.11.016
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2015
    detail.hit.zdb_id: 2018844-4
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  • 5
    Online Resource
    Online Resource
    Humanized mouse model of Rasmussen’s encephalitis supports the immune-mediated hypothesis
    American Society for Clinical Investigation ; 2018
    In:  Journal of Clinical Investigation Vol. 128, No. 5 ( 2018-5-1), p. 2000-2009
    Details
    In: Journal of Clinical Investigation, American Society for Clinical Investigation, Vol. 128, No. 5 ( 2018-5-1), p. 2000-2009
    Type of Medium: Online Resource
    ISSN: 0021-9738 , 1558-8238
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1172/JCI97098
    DOI: 10.1172/JCI97098DS1
    DOI: 10.1172/JCI97098DS2
    Language: English
    Publisher: American Society for Clinical Investigation
    Publication Date: 2018
    detail.hit.zdb_id: 2018375-6
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  • 6
    Online Resource
    Online Resource
    Recent Advances in the Treatment of Epilepsy
    American Medical Association (AMA) ; 2003
    In:  Archives of Neurology Vol. 60, No. 7 ( 2003-07-01), p. 929-
    Details
    In: Archives of Neurology, American Medical Association (AMA), Vol. 60, No. 7 ( 2003-07-01), p. 929-
    Type of Medium: Online Resource
    ISSN: 0003-9942
    URL: Article
    DOI: 10.1001/archneur.60.7.929
    RVK:
    XA 10000
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2003
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  • 7
    Online Resource
    Online Resource
    Evaluation of non‐linear growth curve models in the Vietnamese indigenous Mia chicken
    Wiley ; 2021
    In:  Animal Science Journal Vol. 92, No. 1 ( 2021-01)
    Details
    In: Animal Science Journal, Wiley, Vol. 92, No. 1 ( 2021-01)
    Abstract: Understanding of animal growth is important for the improvement of management and feeding practices; however, little is known about the growth curve in Vietnamese indigenous chicken. This study was performed to determine the most appropriate models for describing the growth curve of Vietnamese Mia chicken. The study evaluated the performances of the Logistic, Gompertz, Richards, and Bridges models of body weights in 224 Mia chickens. Models were fitted using minpack.lm package in R software and Akaike’s information criterion and Bayesian information criterion were used for model comparison. Based on these criteria, the Gompertz and Bridges were the best models for males and females, respectively. Estimated asymmetric weights ( α ) were ranged from 2,241.91 ± 14.74 (g) (Logistic) to 2,623.86 ± 30.23 (g) (Gompertz) for males and from 1,537.36 ± 10.97 (g) (Logistic) and 1,958.36 ± 72.92 (g) (Bridges) for females, respectively. The age at the inflection point was estimated from 9.32 to 10.5 weeks and from 8.51 to 9.86 weeks for males and females, respectively. In conclusion, the Gompertz model is the most suitable model for describing the growth curve of Mia chicken. The parameters obtained from growth models could help define feeding programs to meet nutritional needs from hatching to the age of maximum growth, reproduction programs, and marketing strategies.
    Type of Medium: Online Resource
    ISSN: 1344-3941 , 1740-0929
    URL: Issue
    URL: Article
    DOI: 10.1111/asj.v92.1
    DOI: 10.1111/asj.13483
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2095161-9
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  • 8
    Online Resource
    Online Resource
    Prophylactic anticonvulsants for gliomas: a seven-year retrospective analysis
    Oxford University Press (OUP) ; 2015
    In:  Neuro-Oncology Practice Vol. 2, No. 4 ( 2015-12-01), p. 192-198
    Details
    In: Neuro-Oncology Practice, Oxford University Press (OUP), Vol. 2, No. 4 ( 2015-12-01), p. 192-198
    Abstract: The American Academy of Neurology (AAN) does not recommend routine use of prophylactic antiepileptic drugs (pAEDs) in patients with newly diagnosed brain tumors. If used in the perioperative setting, discontinuation is suggested after the first postoperative week. It is unclear whether such recommendations are followed. Our objective was to compare our perioperative and long-term pAED use in glioma patients with AAN practice parameters. Methods Retrospective chart review was performed on 578 glioma patients from 2006 to 2013. Seizures and AED use were assessed at surgery, 3 months postoperatively and death, last visit or 16 months postoperatively. Patients were divided into three groups at surgery: seizure-free with pAED, seizure-free without pAED, and seizure patients. Long-term pAED use was defined as continued use at 3 months postsurgery without seizures. pAEDs efficacy, factors influencing its use, and survival were examined. Results Out of 578 patients identified, 330 (57.1%) were seizure-naïve preoperatively. There were no significant differences in age, histology, tumor location or resection status between seizure-free populations with and without prophylaxis. Of 330 seizure-naïve patients, 205 (62.1%) received pAEDs at surgery. Ninety-six (46.9%) of those patients were still on pAEDs 3 months postsurgery (median use = 58 days). Rate of long-term prophylaxis use decreased by 13.5% over 6 years (70.3% in 2006; 56.8% in 2012). Phenytoin was preferred in 2006 (98.2%) with increasing use of levetiracetam over 6 years (44.6% in 2012). The only predictive factor for pAED use was complete resection (P = .0069). First seizure prevalence was similar in both seizure-free populations (P = .91). The seizure population had more men (P = .007), younger patients (P 〈 .0001), lower-grade gliomas (P = .0003) and survived longer (P = .001) compared with seizure-free populations. Conclusions In our center, long-term prophylactic AED use is high, deviating from current AAN Guidelines. Corrective measures are warranted.
    Type of Medium: Online Resource
    ISSN: 2054-2585 , 2054-2577
    URL: Article
    DOI: 10.1093/nop/npv018
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2015
    detail.hit.zdb_id: 2768945-1
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  • 9
    Online Resource
    Online Resource
    The Insula and Its Epilepsies
    SAGE Publications ; 2019
    In:  Epilepsy Currents Vol. 19, No. 1 ( 2019-01), p. 11-21
    Details
    In: Epilepsy Currents, SAGE Publications, Vol. 19, No. 1 ( 2019-01), p. 11-21
    Abstract: Insular seizures are great mimickers of seizures originating elsewhere in the brain. The insula is a highly connected brain structure. Seizures may only become clinically evident after ictal activity propagates out of the insula with semiology that reflects the propagation pattern. Insular seizures with perisylvian spread, for example, manifest first as throat constriction, followed next by perioral and hemisensory symptoms, and then by unilateral motor symptoms. On the other hand, insular seizures may spread instead to the temporal and frontal lobes and present like seizures originating from these regions. Due to the location of the insula deep in the brain, interictal and ictal scalp electroencephalogram (EEG) changes can be variable and misleading. Magnetic resonance imaging, magnetic resonance spectroscopy, magnetoencephalography, positron emission tomography, and single-photon computed tomography imaging may assist in establishing a diagnosis of insular epilepsy. Intracranial EEG recordings from within the insula, using stereo-EEG or depth electrode techniques, can prove insular seizure origin. Seizure onset, most commonly seen as low-voltage, fast gamma activity, however, can be highly localized and easily missed if the insula is only sparsely sampled. Moreover, seizure spread to the contralateral insula and other brain regions may occur rapidly. Extensive sampling of the insula with multiple electrode trajectories is necessary to avoid these pitfalls. Understanding the functional organization of the insula is helpful when interpreting the semiology produced by insular seizures. Electrical stimulation mapping around the central sulcus of the insula results in paresthesias, while stimulation of the posterior insula typically produces painful sensations. Visceral sensations are the next most common result of insular stimulation. Treatment of insular epilepsy is evolving, but poses challenges. Surgical resections of the insula are effective but risk significant morbidity if not carefully planned. Neurostimulation is an emerging option for treatment, especially for seizures with onset in the posterior insula. The close association of the insula with marked autonomic changes has led to interest in the role of the insula in sudden unexpected death in epilepsy and warrants additional study with larger patient cohorts.
    Type of Medium: Online Resource
    ISSN: 1535-7597 , 1535-7511
    URL: Article
    DOI: 10.1177/1535759718822847
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2135352-9
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  • 10
    Online Resource
    Online Resource
    Development and validation of the Epilepsy Surgery Satisfaction Questionnaire (ESSQ‐19)
    Wiley ; 2020
    In:  Epilepsia Vol. 61, No. 12 ( 2020-12), p. 2729-2738
    Details
    In: Epilepsia, Wiley, Vol. 61, No. 12 ( 2020-12), p. 2729-2738
    Abstract: No validated tools exist to assess satisfaction with epilepsy surgery. We aimed to develop and validate a new measure of patient satisfaction with epilepsy surgery, the 19‐item Epilepsy Surgery Satisfaction Questionnaire (ESSQ‐19). Methods An initial 31‐item measure was developed based on literature review, patient focus groups, thematic analysis, and Delphi panels. The questionnaire was administered twice, 4‐6 weeks apart, to 229 adults (≥18 years old) who underwent epilepsy surgery ≥1 year earlier, at three centers in Canada and one in Sweden. Participants also completed seven validated questionnaires to assess construct validity. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) assessed the factorial structure of the questionnaire. Cronbach alpha and intraclass correlation coefficients (ICCs) assessed the internal consistency and test‐retest reliability of the ESSQ‐19. Spearman and polyserial correlations assessed construct validity. Results Median age of participants and time since surgery were 42 years (interquartile range [IQR] = 32‐54) and 5 years (IQR = 2‐8.75), respectively. EFA and CFA yielded 18 items that segregated into four domains (mean score [SD] ), namely, seizure control (76.4 [25]), psychosocial functioning (67.3 [26] ), surgical complications (84 [22]), and recovery from surgery (73 [24] ), one global satisfaction item, and a summary global score (74 [21]). The domain and summary scores demonstrated good to excellent internal reliability (Cronbach ⍺ range = .84‐.95) and test‐retest reliability (ICC range = 0.71‐0.85). Construct validity was supported by predicted correlations with other instruments. Significance The ESSQ‐19 is a new, valid, and reliable measure of patient satisfaction with epilepsy surgery that can be used in clinical and research settings.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Issue
    URL: Article
    DOI: 10.1111/epi.v61.12
    DOI: 10.1111/epi.16709
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2002194-X
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