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  • 1
    Online Resource
    Online Resource
    Lipopolysaccharides-Mediated Increase in Glucose-Stimulated Insulin Secretion: Involvement of the GLP-1 Pathway
    American Diabetes Association ; 2014
    In:  Diabetes Vol. 63, No. 2 ( 2014-02-01), p. 471-482
    Details
    In: Diabetes, American Diabetes Association, Vol. 63, No. 2 ( 2014-02-01), p. 471-482
    Abstract: Lipopolysaccharides (LPS) of the cell wall of gram–negative bacteria trigger inflammation, which is associated with marked changes in glucose metabolism. Hyperglycemia is frequently observed during bacterial infection and it is a marker of a poor clinical outcome in critically ill patients. The aim of the current study was to investigate the effect of an acute injection or continuous infusion of LPS on experimentally induced hyperglycemia in wild-type and genetically engineered mice. The acute injection of a single dose of LPS produced an increase in glucose disposal and glucose-stimulated insulin secretion (GSIS). Continuous infusion of LPS through mini-osmotic pumps was also associated with increased GSIS. Finally, manipulation of LPS detoxification by knocking out the plasma phospholipid transfer protein (PLTP) led to increased glucose disposal and GSIS. Overall, glucose tolerance and GSIS tests supported the hypothesis that mice treated with LPS develop glucose-induced hyperinsulinemia. The effects of LPS on glucose metabolism were significantly altered as a result of either the accumulation or antagonism of glucagon-like peptide 1 (GLP-1). Complementary studies in wild-type and GLP-1 receptor knockout mice further implicated the GLP-1 receptor–dependent pathway in mediating the LPS-mediated changes in glucose metabolism. Hence, enhanced GLP-1 secretion and action underlies the development of glucose-mediated hyperinsulinemia associated with endotoxemia.
    Type of Medium: Online Resource
    ISSN: 0012-1797 , 1939-327X
    URL: Article
    DOI: 10.2337/db13-0903
    Language: English
    Publisher: American Diabetes Association
    Publication Date: 2014
    detail.hit.zdb_id: 1501252-9
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  • 2
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    Nhân tố mới gây bệnh béo phì: nội độc tố từ hệ vi sinh vật đường ruột
    Dong Thap University ; 2015
    In:  Dong Thap University Journal of Science , No. 15 ( 2015-10-15), p. 83-85
    Details
    In: Dong Thap University Journal of Science, Dong Thap University, , No. 15 ( 2015-10-15), p. 83-85
    Abstract: Béo phì là bệnh có nhiều nguyên nhân khác nhau và hiện là một trong những căn bệnh phổ biến trên thế giới. Các nghiên cứu gần đây đã đưa ra quan điểm mới về nguyên nhân của bệnh béo phì, chúng được đặc trưng bởi hiện tượng viêm tế bào cấp thấp ở trạng thái trường diễn mà yếu tố khởi đầu là do nội độc tố (Lipopolysaccharide – LPS) sinh ra từ màng ngoài của vi khuẩn Gram âm trong đường ruột. Mặt khác, lượng vi khuẩn Gram âm đường ruột sẽ tăng lên dưới một chế độ ăn giàu béo, và do đó, tỉ lệ LPS trong máu cũng tăng theo, thúc đẩy tiến trình dẫn đến béo phì.
    Type of Medium: Online Resource
    ISSN: 2815-567X , 0866-7675
    URL: Article
    DOI: 10.52714/dthu.15.8.2015.251
    Language: Unknown
    Publisher: Dong Thap University
    Publication Date: 2015
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  • 3
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    Online Resource
    Liver X Receptor–Mediated Induction of Cholesteryl Ester Transfer Protein Expression Is Selectively Impaired in Inflammatory Macrophages
    Ovid Technologies (Wolters Kluwer Health) ; 2009
    In:  Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 29, No. 11 ( 2009-11), p. 1923-1929
    Details
    In: Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 11 ( 2009-11), p. 1923-1929
    Abstract: In the monocyte-macrophage lineage, both in mice and humans, LXR-mediated induction of CETP gene expression is switched on during monocyte-to-macrophage differentiation, magnified by lipid loading, and selectively lost when macrophages become inflammatory.
    Type of Medium: Online Resource
    ISSN: 1079-5642 , 1524-4636
    URL: Article
    DOI: 10.1161/ATVBAHA.109.193201
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2009
    detail.hit.zdb_id: 1494427-3
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  • 4
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    An investigation on design innovation, fabrication and experiment of a soy bean peeling machine-scale
    Science Publishing Corporation ; 2018
    In:  International Journal of Engineering & Technology Vol. 7, No. 4 ( 2018-09-26), p. 2704-
    Details
    In: International Journal of Engineering & Technology, Science Publishing Corporation, Vol. 7, No. 4 ( 2018-09-26), p. 2704-
    Abstract: This study on the mentioned machine is to intend to peel seed coat of dried soybean that applies the friction principles between the seed coat and the conveyor belt. Creating largely frictional contact on the surface of the soybeans leads to the broken link of the seed coat which is responsible for peeling away the seed coat from the soybeans completely. This work demonstrates the design parameters and the fabrication method including the number of rotations of the two conveyors, the contact distance between the conveyor and soybeans. The recommended values of the parameters after studying are carried out as following: the revolution is 120 rpm, the gap between the conveyor and the bean is 6 mm and the conveyor belt width is 400 mm. Based on these results, the finished product reaches around 80.06 percent and the productivity achieves 15 kilograms per hour. 
    Type of Medium: Online Resource
    ISSN: 2227-524X
    URL: Issue
    URL: Article
    DOI: 10.14419/ijet.v7i4
    DOI: 10.14419/ijet.v7i4.14879
    Language: Unknown
    Publisher: Science Publishing Corporation
    Publication Date: 2018
    detail.hit.zdb_id: 2661563-0
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  • 5
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    Phân tích đa hình gen ty thể cox1 của sán lá gan nhỏ Clonorchis sinensis thu thập tại 2 tỉnh Ninh Bình và Phú Thọ
    108 Institute of Clinical Medical and Pharmaceutical Sciences ; 2022
    In:  Journal of 108 - Clinical Medicine and Phamarcy ( 2022-06-24)
    Details
    In: Journal of 108 - Clinical Medicine and Phamarcy, 108 Institute of Clinical Medical and Pharmaceutical Sciences, ( 2022-06-24)
    Abstract: Mục tiêu: Phân tích đặc điểm đa hình gen ty thể cox1 của sán lá gan nhỏ Clonorchis sinensis phân lập ở 2 tỉnh Ninh Bình và Phú Thọ, Việt Nam. Đối tượng và phương pháp: 8 cá thể sán lá gan nhỏ được thu thập từ người ở Ninh Bình (3 cá thể) và Phú Thọ (5 cá thể) được giải trình tự gen cox1 hệ gen ty thể. Các trình tự sau đó được so sánh với nhau và với trình tự tham chiếu trên ngân hàng gen để xác định loài và phân tích đặc điểm đa hình. Kết quả: So sánh với trình tự tham chiếu trên ngân hàng gen, trình tự gen cox1 của sán C. sinensis tại Ninh Bình và Phú Thọ có 13 điểm đa hình khác nhau. Trình tự gen cox1 của các cá thể sán lá gan nhỏ ở Ninh Bình có 11 vị trí khác biệt so với sán lá gan nhỏ ở Phú Thọ, trong đó chủ yếu ở vị trí 9 nucleotid số 66, 114, 243, 381, 933, 954, 1137, 1244, 1380. Kết luận: Trình tự gen cox1 của sán C. sinensis tại Ninh Bình và Phú Thọ cung cấp các thông tin quan trọng có thể sử dụng xác định sự đa dạng di truyền của sán lá gan nhỏ ở các khu vực địa lý khác nhau tại Việt Nam.
    Type of Medium: Online Resource
    ISSN: 1859-2872
    URL: Issue
    URL: Article
    DOI: 10.52389/ydls.v17i4
    DOI: 10.52389/ydls.v17i4.1246
    Language: Unknown
    Publisher: 108 Institute of Clinical Medical and Pharmaceutical Sciences
    Publication Date: 2022
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  • 6
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    Abstract 12211: Water Hammer Shock Causing Rupture Of Vulnerable Cap Of Culprit Lesions In Acute Coronary Syndrome: An Angiographic And Machine Learning Analysis
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Circulation Vol. 144, No. Suppl_1 ( 2021-11-16)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 144, No. Suppl_1 ( 2021-11-16)
    Abstract: Introduction: Acute coronary syndrome (ACS) is caused by rupture of coronary plaques. What triggers these ruptures? Hypothesis: In the field of hydraulics, in a setting of a tank and draining pipe, if the valve at the distal end of the pipe is open, the fluid flows normally. If the valve closes abruptly, the flow next to the valve stops. However the fluid from the tank continues to flow forward and can collide with the distal stationary fluid. This is called water hammer shock. Could the same event happen in coronary arteries? The contraction of the left ventricle (LV) is similar to the abrupt closure of a valve, stopping the myocardial capillary flow. Could the systolic LV contraction trigger water hammer shock? Methods: Angiograms with culprit lesions of ACS (recorded at 15 images/second or 0.06 second per image) were reviewed. The first image was of the artery completely filled with contrast. The subsequent images showed the blood in white color blood moving in over a background of black contrast. The normal flow was laminar. When there was retrograde on top of turbulent flow, this was evidence of a collision between antegrade and retrograde flow (or water hammer shock). The measurements by visual angiographic evaluation and by Machine Learning (ML) included (1) the duration and (2) size of coronary segment with turbulence. The ML program had 2 models (build on Python). Model 1 was built based on U-net and Densenet-121 for vessel segmentation. Model 2 was used for classification of flow. The model 2 was trained based on the convolutional neural network. Results: Angiograms of 20 ACS patients showed laminar flow (90%) in diastole. The flow became turbulent during systole with retrograde flow. The area of collision or water hammer shock showed diffuse coarse mixing of black (contrast) and white (blood). The presence of turbulence matched the location of 85% of ruptured plaques. The duration of turbulence lasted 80% of systole. Special protocols were used successfully to train AI to recognize the lesions, retrograde and turbulent flow. Conclusions: With the new angiographic technique, detailed images of water hammer shock matched the location of ruptured plaques in ACS patients. These results may help to understand the genesis and offer precise prevention and treatment for ACS
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.144.suppl_1.12211
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 1466401-X
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  • 7
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    SỰ TƯƠNG QUAN GIỮA MEN, XÊ MĂNG VÀ NGÀ TẠI ĐƯỜNG NỐI MEN-XÊ MĂNG Ở NHÓM RĂNG CỐI NHỎ Ở NGƯỜI
    Can Tho University of Medicine and Pharmacy ; 2022
    In:  Tạp chí Y Dược học Cần Thơ , No. 49 ( 2022-08-25), p. 185-192
    Details
    In: Tạp chí Y Dược học Cần Thơ, Can Tho University of Medicine and Pharmacy, , No. 49 ( 2022-08-25), p. 185-192
    Abstract: Đặt vấn đề: Đường nối men-xê măng là ranh giới thể hiện sự chuyển giao vật chất bảo vệ ngà bên trong giữa lớp men phủ ở thân răng và lớp xê măng phủ ở chân răng. Ngoài ra, đây còn là một điểm mốc giải phẫu quang trọng trong thực hành lâm sàng. Mục tiêu nghiên cứu: Khảo sát tương quan hình thái giữa men, ngà và xê măng răng tại đường nối men-xê măng của nhóm răng cối nhỏ ở người. Đối tượng và phương pháp nghiên cứu: 40 răng cối nhỏ lành mạnh được nhổ vì lý do chỉnh hình. Răng được xử lý làm tiêu bản răng mài, đường nối men-xê măng được quan sát dưới kính hiển vi quang học. Khảo sát mối tương quan giữa các loại đường nối men – xê măng so với mặt trong và mặt ngoài, cũng như ở răng cối nhỏ hàm trên và hàm dưới. Kết quả: xê măng phủ men răng là tương quan gặp nhiều nhất (39,13%), tương quan men và xê măng đối đầu nhau (36,23%), lộ ngà giữa xê măng và men (17,39%) và hiếm khi gặp men phủ lên bề mặt xê măng (7,25%). Không có sự khác biệt có ý nghĩa về các loại tương quan tại đường nối men-xê măng giữa mặt trong và mặt ngoài, giữa răng hàm trên và răng hàm dưới (p 〉 0,05). Kết luận: Sự tương quan giữa men, xê măng và ngà tại đường nối men-xê măng ở nhóm răng cối nhỏ là rất đa dạng và không thể dự báo trước được. Loại tương quan xê măng phủ lên men là phổ biến nhất. Không có sự khác biệt có ý nghĩa về các loại tương quang giữa mặt trong và mặt ngoài, giữa răng hàm trên và hàm dưới ở nhóm răng cối nhỏ. Bác sĩ lâm sàng cần chú ý đến cấu trúc nhạy cảm này khi tiến hành bất kì một thủ thuật nha khoa nào.
    Type of Medium: Online Resource
    ISSN: 2354-1210
    URL: Issue
    URL: Article
    DOI: 10.58490/ctump.2022i49
    DOI: 10.58490/ctump.2022i49.235
    Language: Unknown
    Publisher: Can Tho University of Medicine and Pharmacy
    Publication Date: 2022
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  • 8
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    Parallel approaches of genetic algorithm in the MIC architecture of the Intel Xeon Phi
    Viet Nam National University Ho Chi Minh City ; 2020
    In:  Science & Technology Development Journal - Engineering and Technology Vol. 2, No. 4 ( 2020-03-24), p. 277-287
    Details
    In: Science & Technology Development Journal - Engineering and Technology, Viet Nam National University Ho Chi Minh City, Vol. 2, No. 4 ( 2020-03-24), p. 277-287
    Abstract: Today, genetic algorithms are widely used in many fields such as bioinformatics, computer science, artificial intelligence, finance ... Genetic algorithms are applied to create high quality solutions for complex optimization problems in the above industries. There have been many studies based on the proposed new hardware architecture that aims to speed up the execution of genetic algorithms as quickly as possible. Some studies suggest parallel genetic algorithms on systems with multicore CPUs and / or graphics processing units (GPUs). However, very few solutions propose a genetic algorithm that can be run on systems that use the new Intel Xeon Phi co-processor (Intel Many-Integrated Core (MIC) architecture). For that reason, we propose and develop the study of the genetic algorithm on high-performance computing systems with Intel Xeon Phi co-processors. This study will present the results of parallel approaches of genetic algorithm on one and more Intel Xeon Phi co-processors by the following methods: (i) Intel Xeon Phi programming model Offload and Native; and (ii) a combined model of MPI and OpenMP. The proposed genetic algorithm can find the optimal schedule for the energy-efficient scheduling problem of virtual machines on physical machines with the goal of minimization total energy consumption. The results of the simulations show the feasibility of implementing a genetic algorithm on one or many Intel Xeon Phi. Genetic algorithm on one or more distributed Intel Xeon Phi always results in faster algorithm execution time than sequential genetic algorithm and the ability to find better solutions using more Intel Xeon Phi. This research result can be applied to other meta-heuristic like TABU search, Ant Colony Optimization.
    Type of Medium: Online Resource
    ISSN: 2615-9872 , 2615-9872
    URL: Article
    DOI: 10.32508/stdjet.v2i4.612
    Language: Unknown
    Publisher: Viet Nam National University Ho Chi Minh City
    Publication Date: 2020
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  • 9
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    The use of an antibiotic order form in a tertiary hospital: Influence on physicians’ prescribing patterns
    Garval Editorial Ltda. ; 2021
    In:  Journal of Pharmacy & Pharmacognosy Research Vol. 9, No. 4 ( 2021-7-1), p. 474-483
    Details
    In: Journal of Pharmacy & Pharmacognosy Research, Garval Editorial Ltda., Vol. 9, No. 4 ( 2021-7-1), p. 474-483
    Abstract: Context: Vietnam is one of the countries at the high alert of antibiotic resistance. Aims: To evaluate the compliance rate and changes in physicians’ prescribing patterns in patients with community-acquired pneumonia (CAP) before and after using the antibiotic order form (AOF) in a tertiary hospital. Methods: 120 inpatient medical records having antibiotic use and 115 patient medical records diagnosed with CAP at a Department of Respiratory Medicine during 3 months before and 3 months after using the AOF were retrospectively collected for assessment. Results: The compliance rate was 92%, and the average rate of filling in information fields was 58%. Comparison of prescribing behavior of CAP in control and intervention group showed that the rate of bacterial culture increased from 70% to 77% (p = 0.690), in which the rate of culture prior prescribing administration increased from 14% to 45% (p 〈 0.001), the initial antibiotic regimen with narrow-spectrum increased from 26% to 36% (p = 0.353), the proportion of patients improved clinically after 72 hours increased from 64% to 89% (p = 0.138), and the de-escalation decreased from 23% to 20% (p = 0.713). The treatment failure at hospital discharge decreased from 12% to 6% (p = 0.447). However, the length of treatment and the days of antibiotic treatment were not significantly different. Conclusions: The compliance rate was high, but the AOF filling rate was incomplete. Improving prescribing patterns and treatment efficacy in CAP patients is a suggestion to combine the AOF into multifaceted interventional efforts for specific patients.
    Type of Medium: Online Resource
    ISSN: 0719-4250
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.56499/jppres21.9.4
    DOI: 10.56499/jppres
    DOI: 10.56499/jppre21.1020_9.4.474
    Language: Unknown
    Publisher: Garval Editorial Ltda.
    Publication Date: 2021
    detail.hit.zdb_id: 2827786-7
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  • 10
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    Enhancement of Color Rendering Index for White Light LED Lamps by Red Y2O3:EU3+ Phosphor
    VSB - Technical University of Ostrava ; 2016
    In:  Advances in Electrical and Electronic Engineering Vol. 14, No. 3 ( 2016-09-27)
    Details
    In: Advances in Electrical and Electronic Engineering, VSB - Technical University of Ostrava, Vol. 14, No. 3 ( 2016-09-27)
    Type of Medium: Online Resource
    ISSN: 1804-3119 , 1336-1376
    URL: Article
    DOI: 10.15598/aeee.v14i3.1642
    Language: Unknown
    Publisher: VSB - Technical University of Ostrava
    Publication Date: 2016
    detail.hit.zdb_id: 2670140-6
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