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  • 1
    Online Resource
    Online Resource
    The natural history of primary progressive multiple sclerosis: insights from the German NeuroTransData registry
    Springer Science and Business Media LLC ; 2023
    In:  BMC Neurology Vol. 23, No. 1 ( 2023-07-05)
    Details
    In: BMC Neurology, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-07-05)
    Abstract: Primary progressive multiple sclerosis (PPMS) is characterised by gradual worsening of disability from symptom onset. Knowledge about the natural course of PPMS remains limited. Methods PPMS patients from the German NeuroTransData (NTD) MS registry with data from 56 outpatient practices were employed for retrospective cross-sectional and longitudinal analyses. The cross-sectional analysis included a contemporary PPMS cohort with a documented visit within the last 2 years before index date (1 Jan 2021). The longitudinal analysis included a disease modifying therapy (DMT)-naïve population and focused on the evolution of expanded disability status scale (EDSS) from the first available assessment at or after diagnosis within the NTD registry to index date. Outcome measures were estimated median time from first EDSS assessment to first 24-week confirmed EDSS ≥ 4 and ≥ 7. Besides EDSS change, the proportion of patients on disability pension were described over time. Results The cross-sectional analysis included 481 PPMS patients (59.9% female, mean [standard deviation, SD] age 60.5 [11.5] years, mean [SD] EDSS 4.9 [2.1] ). Estimated median time from first EDSS assessment after diagnosis to reach 24-week confirmed EDSS ≥ 4 for DMT-naïve patients was 6.9 years. Median time to EDSS ≥ 7 was 9.7 years for 25% of the population. Over a decade mean (SD) EDSS scores increased from 4.6 (2.1) to 5.7 (2.0); the proportion of patients on disability pension increased from 18.9% to 33.3%. Conclusions This study provides first insights into the German NTD real-world cohort of PPMS patients. Findings confirm the steadily deteriorating course of PPMS accompanied by increasingly limited quality of life.
    Type of Medium: Online Resource
    ISSN: 1471-2377
    URL: Article
    DOI: 10.1186/s12883-023-03273-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2041347-6
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  • 2
    Online Resource
    Online Resource
    An efficient magnetothermal actuation setup for fast heating/cooling cycles or long-term induction heating of different magnetic nanoparticle classes
    IOP Publishing ; 2023
    In:  Journal of Physics D: Applied Physics Vol. 56, No. 50 ( 2023-12-14), p. 505002-
    Details
    In: Journal of Physics D: Applied Physics, IOP Publishing, Vol. 56, No. 50 ( 2023-12-14), p. 505002-
    Abstract: Alternating magnetic fields (AMFs) in the ∼100 kHz frequency regime cause magnetic nanoparticles (MNPs) to dissipate heat to their nanoscale environment. This mechanism is beneficial for a variety of applications in biomedicine and nanotechnology, such as localized heating of cancer tissue, actuation of drug release, or inducing conformational changes of molecules. However, engineering electromagnetic resonant circuits which generate fields to efficiently heat MNPs over long time scales, remains a challenge. In addition, many applications require fast heating/cooling cycles over Δ T = 5 ° C–10 °C to switch the sample between different states. Here, we present a home-built magnetothermal actuation setup maximized in its efficiency to deliver stable AMFs as well as to enable fast heating/cooling cycles of MNP samples. The setup satisfies various demands, such as an elaborate cooling system to control heating of the circuit components as well as of the sample due to inductive losses. Fast cycles of remote sample heating/cooling (up to ±15 °C min −1 ) as well as long-term induction heating were monitored via contact-free thermal image recording at sub-mm resolution. Next to characterizing the improved hyperthermia setup, we demonstrate its applicability to heat different types of MNPs: ‘nanoflower’-shaped multicore iron oxide nanoparticles, core shell magnetite MNPs, as well as magnetosomes from magnetotactic bacteria ( Magnetospirillum gryphiswaldense ). MNPs are directly compared in their structure, surface charge, magnetic properties as well as heating response. Our work provides practical guidelines for AMF engineering and the monitoring of MNP heating for biomedical or nano-/biotechnological applications.
    Type of Medium: Online Resource
    ISSN: 0022-3727 , 1361-6463
    URL: Article
    DOI: 10.1088/1361-6463/acfb8f
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 209221-9
    detail.hit.zdb_id: 1472948-9
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  • 3
    Online Resource
    Online Resource
    Magnetic Nanoprobes for Spatio-Mechanical Manipulation in Single Cells
    MDPI AG ; 2021
    In:  Nanomaterials Vol. 11, No. 9 ( 2021-08-31), p. 2267-
    Details
    In: Nanomaterials, MDPI AG, Vol. 11, No. 9 ( 2021-08-31), p. 2267-
    Abstract: Magnetic nanoparticles (MNPs) are widely known as valuable agents for biomedical applications. Recently, MNPs were further suggested to be used for a remote and non-invasive manipulation, where their spatial redistribution or force response in a magnetic field provides a fine-tunable stimulus to a cell. Here, we investigated the properties of two different MNPs and assessed their suitability for spatio-mechanical manipulations: semisynthetic magnetoferritin nanoparticles and fully synthetic ‘nanoflower’-shaped iron oxide nanoparticles. As well as confirming their monodispersity in terms of structure, surface potential, and magnetic response, we monitored the MNP performance in a living cell environment using fluorescence microscopy and asserted their biocompatibility. We then demonstrated facilitated spatial redistribution of magnetoferritin compared to ‘nanoflower’-NPs after microinjection, and a higher magnetic force response of these NPs compared to magnetoferritin inside a cell. Our remote manipulation assays present these tailored magnetic materials as suitable agents for applications in magnetogenetics, biomedicine, or nanomaterial research.
    Type of Medium: Online Resource
    ISSN: 2079-4991
    URL: Article
    DOI: 10.3390/nano11092267
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2662255-5
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  • 4
    Online Resource
    Online Resource
    Heterogeneity of Lipopolysaccharide as Source of Variability in Bioassays and LPS-Binding Proteins as Remedy
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 9 ( 2023-05-07), p. 8395-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 9 ( 2023-05-07), p. 8395-
    Abstract: Lipopolysaccharide (LPS), also referred to as endotoxin, is the major component of Gram-negative bacteria’s outer cell wall. It is one of the main types of pathogen-associated molecular patterns (PAMPs) that are known to elicit severe immune reactions in the event of a pathogen trespassing the epithelial barrier and reaching the bloodstream. Associated symptoms include fever and septic shock, which in severe cases, might even lead to death. Thus, the detection of LPS in medical devices and injectable pharmaceuticals is of utmost importance. However, the term LPS does not describe one single molecule but a diverse class of molecules sharing one common feature: their characteristic chemical structure. Each bacterial species has its own pool of LPS molecules varying in their chemical composition and enabling the aggregation into different supramolecular structures upon release from the bacterial cell wall. As this heterogeneity has consequences for bioassays, we aim to examine the great variability of LPS molecules and their potential to form various supramolecular structures. Furthermore, we describe current LPS quantification methods and the LPS-dependent inflammatory pathway and show how LPS heterogeneity can affect them. With the intent of overcoming these challenges and moving towards a universal approach for targeting LPS, we review current studies concerning LPS-specific binders. Finally, we give perspectives for LPS research and the use of LPS-binding molecules.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms24098395
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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