In:
Current Neuropharmacology, Bentham Science Publishers Ltd., Vol. 18, No. 11 ( 2020-11-09), p. 1054-1063
Abstract:
Until recently, it was thought that there were no lymphatic vessels in the central nervous
system (CNS). Therefore, all metabolic processes were assumed to take place only in the circulation of the cerebrospinal fluid (CSF) and through the blood-brain barrier’s (BBB), which regulate ion
transport and ensure the functioning of the CNS. However, recent findings yield a new perspective: There is an exchange of CSF with interstitial fluid (ISF), which is drained to the paravenous space
and reaches lymphatic nodes at the end. This circulation is known as the gly mphatic system. The
glymphatic system is an extensive network of meningeal lymphatic vessels (MLV) in the basal area of the skull that provides another path for waste products from CNS to reach the bloodstream. MLV
develop postnatally, initially appearing around the foramina in the basal part of the skull and the spinal cord, thereafter sprouting along the skull’s blood vessels and spinal nerves in various areas of
the meninges. VEGF-C protein (vascular endothelial growth factor), expressed mainly by vascular smooth cells, plays an important role in the development of the MLV. The regenerative potential
and plasticity of MLV and the novel discoveries related to CNS drainage offer potential for the treatment of neurodegenerative diseases such as dementia, hydrocephalus, stroke, multiple sclerosis,
and Alzheimer disease (AD). Herein, we present an overview of the structure and function of the glymphatic system and MLV, and their potential involvement in the pathology and progression of
neurodegenerative diseases.
Type of Medium:
Online Resource
ISSN:
1570-159X
DOI:
10.2174/1570159X17666191113103850
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2020
detail.hit.zdb_id:
2119376-9
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