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  • 1
    Online Resource
    Online Resource
    Medic Scientific ; 2022
    In:  Journal of medical pharmaceutical and allied sciences Vol. 11, No. 2 ( 2022-3-30), p. 4629-4635
    In: Journal of medical pharmaceutical and allied sciences, Medic Scientific, Vol. 11, No. 2 ( 2022-3-30), p. 4629-4635
    Abstract: Fucoidan, a sulfated polysaccharide is a well known active principle of marine brown algae, extensively used in food supplement and in pharmaceutical industry. The present study is aimed at evaluation of toxicological profile of fucoidan, isolated from Turbinaria conoides (J.Agardh) Kutzing in both male and female Wistar albino rats. Fucoidan was isolated and studied for Fourier Transform-Infrared spectroscopic analysis to confirm the functional groups. Acute and sub-acute toxicity studies were carried out by Organization for Economic Cooperation and Development guidelines 423 and 407. After treatment period all the animals were sacrificed to evaluate hematological and biochemical parameters. The weights of internal organs recorded and histopathological studies performed. Fourier Transform-Infrared spectroscopic analysis confirms the groups that are correlated with the standard. The animals did not show morbidity or mortality in acute toxicity study at single oral administration of fucoidan at a dose of 2000 mg/kg. In sub-acute toxicity, no statistically significant differences observed in body weight, relative organ weight, food and water intake when compared to control group. No treatment related abnormalities observed in hematological and biochemical parameters except increased levels of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, total cholesterol, triglycerides and blood glucose in both male and female rats. Histopathology revealed no toxic signs at organ level compared to control. From the obtained results, the study suggested that fucoidan can be developed into a novel therapeutic agent and considered as a traditional drug as it does not show any toxic effects. Keywords: Acute toxicity, Fucoidan, Sub-acute toxicity, Turbinaria conoides.
    Type of Medium: Online Resource
    ISSN: 2320-7418
    Language: Unknown
    Publisher: Medic Scientific
    Publication Date: 2022
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  • 2
    In: Toxicology International, Informatics Publishing Limited, ( 2022-12-12), p. 363-377
    Abstract: Introduction: Alginic acid, a polysaccharide is one of the important phytochemical ingredients of brown algae, Turbinaria conoides (J. Agardh) Kutzing. T. conoides has been studied for various pharmacological activities, yet no toxicological information found in the literature therefore, preset study aimed at extraction and isolation of alginic acid and to assess the safety profile through acute and sub acute toxicity study in both male and female rats. Materials and Methods: Alginic acid was characterized through Fourier transform infrared spectroscopy, thermo gravimetric and differential scanning calorimetric analysis. In acute toxicity study, female rats received 2000 mg/kg of isolated product, at a single dose on oral administration. In subacute toxicity study, both male and female rats were given with 100, 200 and 400 mg/kg of the isolated product, orally, for a period of 28 days consecutively and behavioral changes, hematological, biochemical and histopathological investigations were verified. Results and Discussion: In acute toxicity study, no morbidity or mortality was reported with alginic acid treated animals at a dose of 2000 mg/kg. In sub-acute toxicity study, there were no treatment related abnormalities observed in hematological and biochemical parameters except, decreased red blood cell count (400 mg/kg); increased platelets (200 mg/kg) in female rats and increased levels of liver parameters (serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, gamma glutaryl transferase); lipid parameters (total cholesterol, triglycerides and blood glucose) in both male and female rats. Histopathology studies revealed a slight infiltration of cells and congestion in blood vessels in the liver; congestion of alveolar tissue in lungs with 400 mg/kg treated animals. No behavioural changes observed. Conclusion: From the obtained results it is indicated that the oral administration of alginic acid (active principle of T. conoides) did not produce any significant adverse effects in rats of both the sex. Hence, alginic acid was considered as safe to use for further therapeutic purpose.
    Type of Medium: Online Resource
    ISSN: 0976-5131 , 0971-6580
    Language: Unknown
    Publisher: Informatics Publishing Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2581634-2
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  • 3
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 11 ( 2023-7-10)
    Abstract: Tribal or indigenous communities have unique health behaviors, challenges, and inequities that nationally representative surveys cannot document. Odisha has one of India’s largest and most diverse tribal populations, constituting more than a fifth of the state. State and tribe-specific health data generation is recommended in India’s national roadmap of tribal health. The Odisha tribal family health survey (OTFHS) aims to describe and compare the health status of tribal communities in the state of Odisha and to estimate the prevalence of key maternal-child health indicators and chronic diseases. This paper summarizes the methodology, protocols, and tools used in this survey. This is a population-based cross-sectional survey with a multistage random sampling design in 13 (tribal sub-plan areas) districts of Odisha, India. We will include participants of all age groups and gender who belong to tribal communities. The sample size was calculated for each tribe and aggregated to 40,921, which will be collected from 10,230 households spread over 341 clusters. The survey data will be collected electronically in modules consisting of Village, Household, and Individual level questionnaires. The age-group-specific questionnaires were adapted from other national family health surveys with added constructs related to specific health issues of tribal communities, including-critical indicators related to infectious and non-communicable diseases, multimorbidity, nutrition, healthcare-seeking behavior, self-rated health, psycho-social status, maternal and child health and geriatric health. A battery of laboratory investigations will be conducted at the household level and the central laboratory. The tests include liver function tests, kidney function tests, lipid profile, iron profile, and seroprevalence of scrub typhus and hepatitis infections. The datasets from household questionnaires, field measurements and tests and laboratory reports will be connected using a common unique ID in the database management system (DBMS) built for this survey. Robust quality control measures have been built into each step of the survey. The study examines the data focused on different aspects of family health, including reproductive health, adolescent and child health, gender issues in the family, ageing, mental health, and other social problems in a family. Multistage random sampling has been used in the study to enable comparison between tribes. The anthropometric measurements and biochemical tests would help to identify the indicators of chronic diseases among various age groups of the population.
    Type of Medium: Online Resource
    ISSN: 2296-2565
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2711781-9
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  • 4
    Online Resource
    Online Resource
    Baishideng Publishing Group Inc. ; 2021
    In:  World Journal of Stem Cells Vol. 13, No. 7 ( 2021-7-26), p. 841-860
    In: World Journal of Stem Cells, Baishideng Publishing Group Inc., Vol. 13, No. 7 ( 2021-7-26), p. 841-860
    Type of Medium: Online Resource
    ISSN: 1948-0210
    Language: Unknown
    Publisher: Baishideng Publishing Group Inc.
    Publication Date: 2021
    detail.hit.zdb_id: 2583482-4
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