In:
International Journal of Pharmaceutical Sciences and Drug Research, International Journal of Pharmaceutical Sciences and Drug Research, Vol. 1, No. 01 ( 2009-01-01)
Abstract:
The purpose of this research is to prepare Raloxifene Hydrochloride immediate release tablet by wet granulation technique. In order to obtain the best, optimized product six different formulations were developed. Different filler, binder, disintegrant and lubricant were taken as variables. Weight variation, thickness, hardness, friability, disintegration time, in-vitro release and pharmaceutical assay were studied as response variables. Sticking was observed when the formulation containing stearic acid and sodium stearyl fumarate. However, in the remaining four formulation containing magnesium stearate, no sticking was observed. The formulation NP061 was selected as an optimized product. The different physical properties and in-vitro release profile showed best comparable with reference product. Optimization has proven as an effective tool in product development.
Type of Medium:
Online Resource
ISSN:
0975-248X
DOI:
10.25004/IJPSDR.2009.010112
Language:
Unknown
Publisher:
International Journal of Pharmaceutical Sciences and Drug Research
Publication Date:
2009
detail.hit.zdb_id:
2548976-8
SSG:
15,3
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