In:
Journal of Surgical Oncology, Wiley, Vol. 114, No. 1 ( 2016-07), p. 17-21
Abstract:
The aim of this study was to examine the International TILs Working Group 2014 (IWG) recommendations for evaluating the clinical utility of tumor‐infiltrating lymphocytes (TILs) in patients with early triple‐negative breast cancer (TNBC). Methods Records for 133 patients with early TNBC who underwent surgery between 2008 and 2010 were reviewed. A total of 121 of 133 formalin‐fixed, paraffin‐embedded tumor samples were available and reviewed following IWG recommendations. Results Most of the patients had node‐negative T1‐2 tumors and received adjuvant chemotherapy; T1‐2 tumors accounted for 117 of 121 cases. Sixty‐two percent (75/121) of all patients had 〉 10% stromal TILs. Intratumoral TILs and lymphocyte‐predominant breast cancer (LPBC) were observed in 72% and 19% of the patients, respectively. However, there were no significant differences according to the presence of stromal TILs, intratumoral TILs, TILs at the invasive edge, or LPBC in terms of recurrence‐free and overall survival (all P 〉 0.05). A multivariate analysis adjusted for T and N stage, grade, and adjuvant chemotherapy revealed that no TILs parameters were associated with survival outcomes. Conclusions TILs evaluations following the IWG recommendations may not be useful for predicting survival outcomes in patients with early TNBC. J. Surg. Oncol. 2016;114:17–21 . © 2016 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
0022-4790
,
1096-9098
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
1475314-5
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