In:
FEBS Letters, Wiley, Vol. 591, No. 20 ( 2017-10), p. 3348-3359
Abstract:
Recent studies have shown that hyperglycaemia is related to breast cancer progression; however, the mechanisms underlying the relationship between hyperglycaemia and breast cancer cell survival remain unknown. Here, we demonstrate that as compared to physiological glucose conditions, high glucose conditions promote a significant increase in MCF ‐7 cell survival under hypoxia. High glucose levels inhibit apoptosis and induce epithelial‐to‐mesenchymal transition, resulting in increased cell viability under hypoxic conditions. Moreover, high glucose‐treated cells display significant increases in intracellular Zn 2+ levels and reduction in mRNA expression of the zinc (Zn) transporter Zrt‐ and Irt‐like protein 6 (ZIP6) in hypoxia. ZIP 6 deficiency disturbs intracellular Zn 2+ homeostasis, leading to increased cell survival in hypoxia and reduced E‐cadherin expression, indicating that decreased ZIP 6 expression is strongly associated with resistance to hypoxia.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/feb2.2017.591.issue-20
DOI:
10.1002/1873-3468.12797
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
212746-5
detail.hit.zdb_id:
1460391-3
SSG:
12
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