In:
Annals of Nutrition and Metabolism, S. Karger AG, Vol. 46, No. 6 ( 2002), p. 259-267
Abstract:
〈 i 〉 Aim: 〈 /i 〉 The angiotensin-I-converting enzyme (ACE) inhibitory and antihypertensive activities of wakame hydrolysates have been investigated in several studies. 〈 i 〉 Methods: 〈 /i 〉 Wakame ( 〈 i 〉 Undaria pinnatifida 〈 /i 〉 ) was hydrolyzed using 17 kinds of proteases and the inhibitory activity of the hydrolysates for ACE was measured. Of these hydrolysates 4 with potent ACE inhibitory activity were administered singly and orally to spontaneously hypertensive rats (SHR). 〈 i 〉 Results: 〈 /i 〉 The systolic blood pressure of SHR decreased significantly after single oral administration of protease S ‘Amano’ and proleather FG-F hydrolysates (10 mg protein/kg body weight). In a long-term feeding experiment, 7-week-old SHR were fed standard chow supplemented with protease S ‘Amano’-derived wakame hydrolysates for 10 weeks. In SHR fed the 1 and 0.1% wakame hydrolysates, elevation of systolic blood pressure was still significantly suppressed for 7 weeks. 〈 i 〉 Conclusions: 〈 /i 〉 The hydrolysates derived from wakame by protease S ‘Amano’ have a powerful ACE-inhibitory activity (IC 〈 sub 〉 50 〈 /sub 〉 = 86 µg protein/ml) and were effective in spite of their slight bitterness as ‘physiologically functional food’ with antihypertensive activity.
Type of Medium:
Online Resource
ISSN:
0250-6807
,
1421-9697
Language:
English
Publisher:
S. Karger AG
Publication Date:
2002
detail.hit.zdb_id:
1481977-6
Permalink