In:
Molecules, MDPI AG, Vol. 25, No. 4 ( 2020-02-17), p. 884-
Abstract:
Background: The design and development of prodrugs is the most common and effective strategy to overcome pharmacokinetic and pharmacodynamic drawbacks of active drugs. A respected number of prodrugs have been reached the drugs market throughout history and the recent years have witnessed a significant increase in the use of prodrugs as a replacement of their parent drugs for an efficient treatment of various ailment. Methods: A Scan conducted to find recent approved prodrugs and prodrugs in development. Results: Selected prodrugs were reported and categorized in accordance to their target systems. Conclusions: the prodrug approach has shown many successes and still remains a viable and effective approach to deliver new active agents. This conclusion is supported by the recent approved prodrugs and the scan of clinical trials conducted between 2013–2018.
Type of Medium:
Online Resource
ISSN:
1420-3049
DOI:
10.3390/molecules25040884
Language:
English
Publisher:
MDPI AG
Publication Date:
2020
detail.hit.zdb_id:
2008644-1
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