In:
Asian Journal of Chemistry, Asian Journal of Chemistry, Vol. 33, No. 6 ( 2021), p. 1267-1272
Abstract:
In the present study, osajin-1,2,3-triazole hybrids were designed, synthesized and evaluated for their
anti-proliferative activity against MCF-7, PC-3 and Hela cell lines. Many of the synthesized hybrid derivatives were found potent than the parent compound, osajin (1). All the semi-synthesized derivatives
(3a-j) were characterized by using mass and NMR spectroscopic techniques. Among the newly synthesized compounds, 3c, 3d, and 3e were shown promising activities against the tested cell lines
compared with doxorubicin standard. In addition, molecular docking studies of the synthesized compounds have shown a good correlation with in silico molecular docking analysis by exhibiting
strong interactions with the inhibitor HERA-protein.
Type of Medium:
Online Resource
ISSN:
0975-427X
,
0970-7077
DOI:
10.14233/ajchem.2021.23195
Language:
English
Publisher:
Asian Journal of Chemistry
Publication Date:
2021
detail.hit.zdb_id:
3140213-6
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