In:
Journal of Obstetrics and Gynaecology Research, Wiley, Vol. 45, No. 1 ( 2019-01), p. 96-103
Abstract:
To compare serum levels of angiogenesis‐related factors between 14 women with HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome and a woman with acute fatty liver of pregnancy (AFLP). Methods Serum samples were collected in 2004–2008 and 2013–2016. The levels of soluble fms‐like tyrosine kinase 1 (sFlt‐1) and placental growth factor (PlGF) were measured by an automated electrochemiluminescence immunoassay using Elecsys sFlt‐1 and Elecsys PlGF. After logarithmic transformation, levels of sFlt‐1, PlGF and the sFlt‐1/PlGF ratio in a woman with AFLP were compared with those in women with HELLP syndrome, using the one‐sample t ‐test. Results At 37 weeks of gestation, a patient was diagnosed with AFLP based on Swansea criteria (showing six features including elevated transaminases), and she also showed a duodenal ulcer with active bleeding, thrombocytopenia and hypertension. Her serum levels of sFlt‐1 and sFlt‐1/PlGF ratio were significantly higher than in those with HELLP syndrome (273 040 pg/mL vs 15 135 [mean], P 〈 0.001; 4236 vs 224, P 〈 0.001; respectively). However, her serum level of PlGF was not significantly different from those with HELLP syndrome. Conclusion Serum levels of sFlt‐1 and the sFlt‐1/PlGF ratio, but not PlGF, in a woman with AFLP were markedly higher than those in women with HELLP syndrome. AFLP may be a different clinical entity from HELLP syndrome based on angiogenesis‐related factors. Clinically, the sFlt‐1/PlGF ratio may be used to rapidly distinguish AFLP from HELLP syndrome.
Type of Medium:
Online Resource
ISSN:
1341-8076
,
1447-0756
DOI:
10.1111/jog.2019.45.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2079101-X
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