In:
Diabetes Care, American Diabetes Association, Vol. 24, No. 12 ( 2001-12-01), p. 2127-2133
Abstract:
OBJECTIVE—The significance of abdominal visceral fat accumulation was evaluated in Japanese men with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS—The IGT subjects (n = 123) were aged 55 ± 9 years with a BMI of 24 ± 3 kg/m2. The 148 control subjects with normal glucose tolerance (NGT) were matched for age and BMI. IGT and NGT were classified according to the 1985 World Health Organization criteria. Abdominal fat distribution was analyzed by computed tomography at umbilical level. Plasma lipid, glucose, and insulin concentrations and blood pressure (BP) were measured. RESULTS—In subjects with IGT, the average visceral fat area (VFA) was significantly greater than in subjects with NGT. Fasting insulin, the sum of insulin concentrations during an oral glucose tolerance test, insulin resistance according to a homeostasis model assessment for insulin resistance (HOMA-IR), systolic BP, and serum triglyceride were significantly higher, whereas the ΔI30–0/ΔG30–0 was significantly lower, in subjects with IGT. Subjects with IGT and NGT were then divided into three subgroups according to the number of risk factors they possessed (dyslipidemia, hypertension, neither, or both). In both IGT and NGT subjects, BMI, VFA, subcutaneous fat area, fasting insulin, HOMA-IR, and insulin secretion of the homeostasis model assessment were significantly higher in the double–risk factor subgroup than in the no–risk factor subgroup, and VFA was a potent and independent variable in association with the presence of a double risk factor. CONCLUSIONS—Visceral fat accumulation is a major contributor for multiple risk factor clustering in Japanese men with IGT and NGT.
Type of Medium:
Online Resource
ISSN:
0149-5992
,
1935-5548
DOI:
10.2337/diacare.24.12.2127
Language:
English
Publisher:
American Diabetes Association
Publication Date:
2001
detail.hit.zdb_id:
1490520-6
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