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  • 1
    Online Resource
    Online Resource
    50 Million Years of Genomic Stasis in Endosymbiotic Bacteria
    American Association for the Advancement of Science (AAAS) ; 2002
    In:  Science Vol. 296, No. 5577 ( 2002-06-28), p. 2376-2379
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 296, No. 5577 ( 2002-06-28), p. 2376-2379
    Abstract: Comparison of two fully sequenced genomes of Buchnera aphidicola , the obligate endosymbionts of aphids, reveals the most extreme genome stability to date: no chromosome rearrangements or gene acquisitions have occurred in the past 50 to 70 million years, despite substantial sequence evolution and the inactivation and loss of individual genes. In contrast, the genomes of their closest free-living relatives, Escherichia coli and Salmonella spp., are more than 2000-fold more labile in content and gene order. The genomic stasis of B. aphidicola , likely attributable to the loss of phages, repeated sequences, and recA , indicates that B. aphidicola is no longer a source of ecological innovation for its hosts.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.1071278
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2002
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    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Characterization of the Genome Composition of Bartonella koehlerae by Microarray Comparative Genomic Hybridization Profiling
    American Society for Microbiology ; 2005
    In:  Journal of Bacteriology Vol. 187, No. 17 ( 2005-09), p. 6155-6165
    Details
    In: Journal of Bacteriology, American Society for Microbiology, Vol. 187, No. 17 ( 2005-09), p. 6155-6165
    Abstract: Bartonella henselae is present in a wide range of wild and domestic feline hosts and causes cat-scratch disease and bacillary angiomatosis in humans. We have estimated here the gene content of Bartonella koehlerae , a novel species isolated from cats that was recently identified as an agent of human endocarditis. The investigation was accomplished by comparative genomic hybridization (CGH) to a microarray constructed from the sequenced 1.93-Mb genome of B. henselae . Control hybridizations of labeled DNA from the human pathogen Bartonella quintana with a reduced genome of 1.58 Mb were performed to evaluate the accuracy of the array for genes with known levels of sequence divergence. Genome size estimates of B. koehlerae by pulsed-field gel electrophoresis matched that calculated by the CGH, indicating a genome of 1.7 to 1.8 Mb with few unique genes. As in B. quintana , sequences in the prophage and the genomic islands were reported absent in B. koehlerae . In addition, sequence variability was recorded in the chromosome II-like region, where B. koehlerae showed an intermediate retention pattern of both coding and noncoding sequences. Although most of the genes missing in B. koehlerae are also absent from B. quintana , its phylogenetic placement near B. henselae suggests independent deletion events, indicating that host specificity is not solely attributed to genes in the genomic islands. Rather, the results underscore the instability of the genomic islands even within bacterial populations adapted to the same host-vector system, as in the case of B. henselae and B. koehlerae .
    Type of Medium: Online Resource
    ISSN: 0021-9193 , 1098-5530
    URL: Article
    DOI: 10.1128/JB.187.17.6155-6165.2005
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2005
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    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Genome Rearrangements, Deletions, and Amplifications in the Natural Population of Bartonella henselae
    American Society for Microbiology ; 2006
    In:  Journal of Bacteriology Vol. 188, No. 21 ( 2006-11), p. 7426-7439
    Details
    In: Journal of Bacteriology, American Society for Microbiology, Vol. 188, No. 21 ( 2006-11), p. 7426-7439
    Abstract: Cats are the natural host for Bartonella henselae , an opportunistic human pathogen and the agent of cat scratch disease. Here, we have analyzed the natural variation in gene content and genome structure of 38 Bartonella henselae strains isolated from cats and humans by comparative genome hybridizations to microarrays and probe hybridizations to pulsed-field gel electrophoresis (PFGE) blots. The variation in gene content was modest and confined to the prophage and the genomic islands, whereas the PFGE analyses indicated extensive rearrangements across the terminus of replication with breakpoints in areas of the genomic islands. We observed no difference in gene content or structure between feline and human strains. Rather, the results suggest multiple sources of human infection from feline B. henselae strains of diverse genotypes. Additionally, the microarray hybridizations revealed DNA amplification in some strains in the so-called chromosome II-like region. The amplified segments were centered at a position corresponding to a putative phage replication initiation site and increased in size with the duration of cultivation. We hypothesize that the variable gene pool in the B. henselae population plays an important role in the establishment of long-term persistent infection in the natural host by promoting antigenic variation and escape from the host immune response.
    Type of Medium: Online Resource
    ISSN: 0021-9193 , 1098-5530
    URL: Article
    DOI: 10.1128/JB.00472-06
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2006
    detail.hit.zdb_id: 1481988-0
    SSG: 12
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