In:
Histopathology, Wiley, Vol. 65, No. 6 ( 2014-12), p. 764-774
Abstract:
Granular cell tumours ( GCT s) are uncommon in the gastrointestinal tract, particularly in the colorectum. Herein, we report a series of 30 colorectal GCT s and discuss the properties of colorectal GCT s based on histopathological and immunohistochemical studies. Methods and results Searching the surgical pathology files identified 30 cases of colorectal GCT s for 2005–2013. A broad panel of antibodies including neural and macrophage markers were used for immunohistochemical evaluation. Colorectal GCT s predominantly involved the right colon and showed increased nuclear atypia including nuclear pleomorphism and nuclear spindling. All 24 cases with mucosal tumour components had infiltrative growth patterns within the mucosa. In all available cases, diffuse strong immunopositivity was observed for S100 and SOX 10 of schwannian differentiation markers, as well as for CD 68. Other neuronal lineage markers, including CD 56, neuron‐specific enolase, nestin, and synaptophysin showed consistently high expression rates. The immunohistochemical results are suggestive for a neural origin of GCT s. Conclusion Histopathological and immunohistochemical features of colorectal GCT s were delineated in this large series of 30 colorectal GCT s. Although the incidence of GCT s is relatively low, clinicians and pathologists need to be aware of GCT in the differential diagnosis.
Type of Medium:
Online Resource
ISSN:
0309-0167
,
1365-2559
DOI:
10.1111/his.2014.65.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2006447-0
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