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  • 1
    Online Resource
    Online Resource
    A Large Scalp Defect Coverage With Pedicled Free Flap Using the Wrist as a Free Flap Carrier
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Journal of Craniofacial Surgery Vol. 30, No. 3 ( 2019-05), p. e270-e272
    Details
    In: Journal of Craniofacial Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 30, No. 3 ( 2019-05), p. e270-e272
    Abstract: The absence of an adequate recipient vessel for free flap pedicle anastomosis near local defect sites discourages surgeons from performing free flap transfers over the scalp because of the challenging neck dissection and the thrombogenic potential of vein grafts for pedicle elongation. We present a case in which a large scalp defect was successfully reconstructed using the wrist as a “free flap carrier,” which is an alternative method. A 78-year-old patient with a totally occluded common carotid artery presented to our clinic with a large scalp defect. Reconstruction of the scalp defect was performed in a 2-stage procedure. In the first stage, a free latissimus dorsi (LD) muscle flap was transferred to the defect site, and the pedicle anastomosis was held at the ipsilateral wrist to provide inflow and outflow of blood through the radial artery and vena comitante and cephalic vein that were anastomosed to the flap pedicle. After subsequent split-thickness skin graft, the elevated position of the arm was achieved using a splint and sutures for 3 weeks. In the second stage, the flap was divided, and an additional skin graft over the flap division site and radial artery repair with vein graft was performed. Successful coverage of the scalp defect was confirmed on postoperative day 14 of the second procedure with no complications.
    Type of Medium: Online Resource
    ISSN: 1049-2275 , 1536-3732
    URL: Article
    DOI: 10.1097/SCS.0000000000005334
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 1159501-2
    detail.hit.zdb_id: 2060546-8
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  • 2
    Online Resource
    Online Resource
    Cyclin D1 and PRAME expression in distinguishing melanoma in situ from benign melanocytic proliferation of the nail unit
    Springer Science and Business Media LLC ; 2022
    In:  Diagnostic Pathology Vol. 17, No. 1 ( 2022-12)
    Details
    In: Diagnostic Pathology, Springer Science and Business Media LLC, Vol. 17, No. 1 ( 2022-12)
    Abstract: Distinguishing benign lesion from early malignancy in melanocytic lesions of the nail unit still remains a diagnostic challenge, both clinically and histopathologically. While several immunohistochemistry (IHC) stainings have been suggested to help discriminate benign subungual melanocytic proliferation (SMP) and subungual melanoma in situ (MIS), the diagnostic utility of IHC staining for cyclin D1 and PRAME has not been thoroughly investigated in melanocytic lesions of nail unit. Methods This retrospective study included cases of benign SMP and subungual MIS confirmed by biopsy at Asan Medical Center from January 2016 to December 2020. Cases of melanocytic activation without proliferation and melanoma where dermal invasion was identified were excluded. Cyclin D1 and PRAME expression was assessed by counting proportion of melanocytes with nuclear positivity under 200x magnification. Results A total of 14 patients with benign SMP and 13 patients with subungual MIS were included in this study. 11 patients with benign SMP (71.4%) and 5 patients with subungual MIS (38.5%) showed  〉  60% nuclear immunostaining for cyclin D1, respectively. While 13 patients with benign SMP (92.9%) showed totally negative staining for PRAME, 10 patients with subungual MIS (76.9%) exhibited  〉  50% nuclear immunostaining for PRAME. Using the cutoff of 10%, PRAME exhibited good overall discrimination between benign SMP and subungual MIS (AUC = 0.849, 95% CI = 0.659–0.957). Conclusions This study suggests that PRAME IHC staining as a reliable discriminator in distinguishing subungual MIS from benign SMP.
    Type of Medium: Online Resource
    ISSN: 1746-1596
    URL: Article
    DOI: 10.1186/s13000-022-01218-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2210518-9
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  • 3
    Online Resource
    Online Resource
    Predicting the Natural Course of Hemivertebra in Early Childhood : Clinical Significance of Anteroposterior Discordance Based on Three-dimensional Analysis
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Spine Vol. 44, No. 23 ( 2019-12-1), p. E1362-E1368
    Details
    In: Spine, Ovid Technologies (Wolters Kluwer Health), Vol. 44, No. 23 ( 2019-12-1), p. E1362-E1368
    Abstract: A retrospective cohort, radiographic study. Objective. The aim of this study was to compare the progression of scoliosis owing to single hemivertebra (HV) during early childhood, according to the anteroposterior discordance obtained from the three-dimensional computed tomography (3D-CT) studies. Summary of Background Data. Previous studies have utilized 3D-CT for the classification of congenital spinal deformities and have introduced the concept of two types of deformity: unison and discordant anomalies. However, there have been no further studies on the clinical significance of these discordant deformities, especially in the identification of deformities that will progress and require an operation. Methods. We retrospectively analyzed 97 cases of single HV with thoracolumbar scoliosis, diagnosed in children before the age of 3 years and followed up past the age of 6 years. The segmentation of the anterior and posterior components, and anteroposterior discordance of the HV were evaluated using 3D-CT images. Coronal segmental curve angle (SCA) and balance were measured using whole spine plain radiographs. Results. Using 3D-CT, 41 (42.3%) cases of unison HV and 56 (57.7%) discordant HV were identified. Unison HV comprised 21 (21.6%) cases of fully segmented (FS) unison HV and 20 (20.6%) cases of semi-segmented unison HV with corresponding anterior and posterior segmentation. Fifty-six cases of discordant HV were further classified into 4 different types. In the 86 patients who were followed without operation between the ages of 3 and 6 years, the average progression of SCA was significantly larger in FS unison HV (one-way analysis of variance, P   〈  0.001). Ten of 86 (11.6%) patients showed a coronal imbalance at the age of 6 years, but the proportion of patients with coronal imbalance was not significantly different among the deformity types. Conclusion. Anteroposterior discordance on 3D analysis is a useful indicator for the progression of congenital scoliosis due to single HV in early childhood. Level of Evidence: 4
    Type of Medium: Online Resource
    ISSN: 0362-2436 , 1528-1159
    URL: Article
    DOI: 10.1097/BRS.0000000000003168
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2002195-1
    detail.hit.zdb_id: 752024-4
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  • 4
    Online Resource
    Online Resource
    Partial unilateral lentiginosis: a clinicopathological analysis of 32 cases on the head and neck area in Korea
    Wiley ; 2021
    In:  International Journal of Dermatology Vol. 60, No. 11 ( 2021-11), p. 1376-1384
    Details
    In: International Journal of Dermatology, Wiley, Vol. 60, No. 11 ( 2021-11), p. 1376-1384
    Abstract: Partial unilateral lentiginosis (PUL) is a rare acquired circumscribed hyperpigmentation characterized by multiple simple lentigines involving half of the body. Since the previous studies of PUL were mostly based on case reports and the current literature lacks well‐designed retrospective studies that involve a large number of cases, PUL is not a well‐defined entity, and differential diagnosis with nevus spilus is still difficult. This study aims to evaluate clinical and histopathological characteristics and treatment outcomes of PUL on head and neck area of Koreans. Methods Thirty‐two patients with PUL on head and neck area were diagnosed clinicohistopathologically at the Asan Medical Center from 2004 to 2017. Their medical records, photographs, and biopsy specimens were reviewed, and immunohistochemical staining for protein kinase C (PKC)‐βΙΙ was evaluated for melanogenic activity. Results Four patients (12.5%) of PUL had congenital lesions, and 24 (75.0%) had age of onset younger than 10 years. Confluency of lentiginous lesions (100%) and mild to moderate background interlesional hyperpigmentation (90.6%) were observed. The lentiginous lesions showed increased melanocytes, melanophages, basal melanins, lentiginous hyperplasia, and perivascular inflammatory cells compared with background interlesional hyperpigmentation, and PKC‐βΙΙ was focally positive in 7 of 12 stained PUL lesions. Among the 16 patients who received laser treatments, 10 (62.5%) showed more than 50% of improvement. Conclusions The findings of this study will allow for improved diagnosis of PUL and understanding of its features, which may facilitate proper management in the future.
    Type of Medium: Online Resource
    ISSN: 0011-9059 , 1365-4632
    URL: Issue
    URL: Article
    DOI: 10.1111/ijd.v60.11
    DOI: 10.1111/ijd.15630
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 412254-9
    detail.hit.zdb_id: 2020365-2
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  • 5
    Online Resource
    Online Resource
    Granulomatous Reaction to Dermal Injection of Growth Factors from Umbilical Cord Blood-Derived Mesenchymal Stem Cells: A Case Report
    Informa UK Limited ; 2021
    In:  International Medical Case Reports Journal Vol. Volume 14 ( 2021-10), p. 719-723
    Details
    In: International Medical Case Reports Journal, Informa UK Limited, Vol. Volume 14 ( 2021-10), p. 719-723
    Type of Medium: Online Resource
    ISSN: 1179-142X
    URL: Article
    DOI: 10.2147/IMCRJ.S324357
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2495077-4
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