In:
BMC Pulmonary Medicine, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2007-12)
Abstract:
Endothelin-1 (EDN1) has been involved in the development of airway obstruction and inflammation in asthma. Several polymorphisms have been identified among the genes encoding for preproET1, an inactive precursor of ET-1, and for ET A (EDNRA) and ET B (EDNRB), the two receptors for EDN1. In the present work, we hypothesised that molecular variation in these genes could be a major determinant of the degree of bronchial obstruction. The purpose of this study was to investigate whether the genetic polymorphisms of preproET-1 , EDNRA and EDNRB genes were associated with the degree of airway obstruction, assessed by FEV 1 . Methods Polymorphisms of preproET-1, EDNRA and EDN RB were first studied in a population of adult asthmatic patients. Results were confirmed in a large population of adults from the general population from the ECRHS II study. Results In our population of adult asthmatic patients, the EDNRB-30G 〉 A (Leu277Leu) polymorphism (GG genotype) is strongly associated with a low FEV 1 and with a higher percentage of patients with FEV1 〈 80% of predicted value. No relationship was found between pulmonary function and EDNRA-1363C 〉 T (His323His) or preproET-1-595G 〉 T (Lys198Asp) polymorphism. In the adult population from the ECRHS II, we found a similar association between GG genotype and a low FEV 1 or a higher percentage of subjects with FEV1 〈 80% predicted, especially in the subgroups of asthmatics subjects (OR = 4.31 (95%CI 1.03 – 18.04)) and smokers (OR = 7.42 (95%CI 1.69 – 32.6)). Conclusion the EDNRB-30G 〉 A polymorphism could be a determinant of airway obstruction in humans with predisposing factors such as tobacco smoke exposure or asthma.
Type of Medium:
Online Resource
ISSN:
1471-2466
DOI:
10.1186/1471-2466-7-5
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2007
detail.hit.zdb_id:
2059871-3
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