In:
Journal of HIV and AIDS, Sci Forschen, Inc., Vol. 6, No. 1 ( 2020)
Abstract:
Introduction: Novel plant DING proteins (full-length 38 kDa p38SJ, and 27 kDa p27SJ) exhibit phosphatase activity and modulate HIV-1 gene transcription. Previously, we demonstrated that DING regulates HIV-1 gene transcription by dephosphorylation and inactivation of CTD RNA polymerase II, the major elongating factor of HIV-1 Long Terminal Repeats (LTR). Because the transcription of HIV-1 is controlled by several viral and cellular factors, including p65/p50 subunits of NF-κB, we hypothesized that DING phosphatase can also affect the phosphorylation and activity of p65 NF-κB, in addition to C-terminal Domain (CTD) of RNA Polymerase II (RNAPII), to suppress HIV-1 gene transcription and inhibit HIV-1 infection.
Type of Medium:
Online Resource
ISSN:
2380-5536
DOI:
10.16966/2380-5536.175
Language:
Unknown
Publisher:
Sci Forschen, Inc.
Publication Date:
2020
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