In:
Current Pharmaceutical Design, Bentham Science Publishers Ltd., Vol. 28, No. 10 ( 2022-03), p. 787-797
Abstract:
Venous thromboembolism (VTE) is a term used to compositely describe deep vein
thrombosis (DVT) and pulmonary embolism (PE). Overall, the incidence of VTE after major abdominal and pelvic surgery has been reported to be between 10% and 40%. Objective: The aim of this study is to estimate the incidence of post-operative VTE in patients undergoing major
abdominal surgery for cancer, to identify risk factors associated with VTE, and to assess available thromboprophylaxis tools. Methods: A Medline and Cochrane literature search from database inception until February 1st, 2021 was performed
according to the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses)
guidelines. Results: Thirty-one studies met our eligibility criteria and were included in the current review. In total, 435,492
patients were identified and the overall incidence of VTE was 2.19% (95% CI: 1.82-2.38). Τhe following risk factors were associated with VTE: smoking, advanced age ( 〉 70 years), a history of diabetes mellitus, American
Society of Anesthesiologists’ (ASA) classification of Physical Health class III or IV, a history of cardiovascular or pulmonary disease, a history of DVT or PE, elevated plasma fibrinogen level, c-reactive protein (CRP) level,
cancer stage III or IV, postoperative acute respiratory distress syndrome (ARDS), prolonged postoperative hospital stay, previous steroid use, history of Inflammatory Bowel Disease (IBD), heart failure and neoadjuvant
and adjuvant chemotherapy. Conclusion: VTE remains an important complication after major abdominal surgery for cancer and seems to
increase mortality rates.
Type of Medium:
Online Resource
ISSN:
1381-6128
DOI:
10.2174/1381612828666220217140639
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2022
SSG:
15,3
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