In:
Caries Research, S. Karger AG, Vol. 50, No. 2 ( 2016), p. 89-96
Abstract:
〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 Dental caries is a multifactorial, infectious disease where genetic predisposition plays an important role. Insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) has very recently been associated with caries in Polish children. The aim of this study was to analyze 〈 i 〉 ACE 〈 /i 〉 I/D polymorphism in a group of caries-free children versus subjects affected by dental caries in the Czech population. 〈 b 〉 〈 i 〉 Materials and Methods: 〈 /i 〉 〈 /b 〉 In this case-control study, 182 caries-free children (with decayed/missing/filled teeth, DMFT = 0), 561 subjects with dental caries (DMFT ≥1) aged 13-15 years and 220 children aged 2-6 years with early childhood caries (ECC, dmft ≥1) were included. Genotype determination of 〈 i 〉 ACE 〈 /i 〉 I/D polymorphism in intron 16 was based on the TaqMan method. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Although no significant differences in the allele or genotype frequencies between the caries-free children and those affected by dental caries were observed, statistically significant differences between the children with DMFT = 0 and the subgroup of 179 patients with high caries experience (DMFT ≥4; p 〈 0.01 and p 〈 0.05, respectively) were detected. The comparison of DD versus II+ID genotype frequencies between the patients with DMFT ≥1 or DMFT ≥4 and healthy children also showed significant differences (31.5% or 35.6% vs. 23.6%, p 〈 0.05 or p 〈 0.01, respectively). A gender-based analysis identified a significant difference in the DD versus II+ID genotype frequencies only in girls (p 〈 0.05). In contrast, no significant association of 〈 i 〉 ACE 〈 /i 〉 I/D polymorphism with ECC in young children was found (p 〉 0.05). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 〈 i 〉 ACE 〈 /i 〉 I/D polymorphism may be associated with caries in permanent but not primary dentition, especially in girls in the Czech population.
Type of Medium:
Online Resource
ISSN:
0008-6568
,
1421-976X
Language:
English
Publisher:
S. Karger AG
Publication Date:
2016
detail.hit.zdb_id:
1482046-8
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