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  • 1
    In: Knowledge and Process Management, Wiley
    Abstract: The study investigated the impact of high‐involvement work systems (HIWS) on knowledge‐sharing intention (KSI) through the mediation of organizational commitment (OC) and the moderation of workplace allocentrism, particularly in the manufacturing units of small and medium enterprises operating in Pakistan. Data collection involved 328 workers, utilizing self‐administered structured questionnaires translated into Urdu to ensure understanding and inclusivity. SmartPLS software was used to analyze data using the structural equation modeling technique for the examination of complex relationships between multiple variables simultaneously. The findings suggest that the association between HIWS and KSI strengthens among the individuals high in workplace allocentrism and that cultural factors play a significant role in shaping how employees respond to HIWS and engage in knowledge‐sharing behaviors. The study highlights the importance of considering cultural factors in organizational practices and strategies, thus providing novel insights for entrepreneurs to enhance the performance, innovation, and competitiveness of their enterprises through a knowledge‐sharing culture. Overall, study offers valuable contributions to both academia and practice by shedding light on the intricate relationships between HIWS, KSI, OC, and workplace allocentrism.
    Type of Medium: Online Resource
    ISSN: 1092-4604 , 1099-1441
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2021210-0
    SSG: 3,2
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  • 2
    Online Resource
    Online Resource
    Hipatia Press ; 2021
    In:  International and Multidisciplinary Journal of Social Sciences Vol. 10, No. 1 ( 2021-03-30), p. 81-103
    In: International and Multidisciplinary Journal of Social Sciences, Hipatia Press, Vol. 10, No. 1 ( 2021-03-30), p. 81-103
    Abstract: The shadow impacts of the COVID-19 pandemic are critical, especially for children with intellectual and/or developmental disabilities (IDDs). Financial constraints and home confinement have increased the challenges for caregivers to meet the educational and health needs of children with IDDs. Hence, this research examines the impact of COVID-19 lockdown on families with IDDs children in rural Pakistan. Overall, 176 parents participated in this study and provided valuable responses through interview technique. Parents responded to five (05) open-ended questions. Results indicated that parents of children with IDDs are facing various challenges including financial constraints, social lockdown, deteriorated health conditions of their children, reduced or no health services, closure of educational institutes, negative behavioral impacts, and slow mental development. Still, a subset of parents also reported the positive side of lockdown, indicating that staying at home resulted in improved relationships. The findings of the study suggest that parents of children with IDDs are confronted with significant challenges that increase their stress.
    Type of Medium: Online Resource
    ISSN: 2014-3680
    Language: Unknown
    Publisher: Hipatia Press
    Publication Date: 2021
    detail.hit.zdb_id: 2719850-9
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  • 3
    In: Critical Care, Springer Science and Business Media LLC, Vol. 26, No. 1 ( 2022-12)
    Abstract: In response to the COVID-19 pandemic, concerted efforts were made by provincial and federal governments to invest in critical care infrastructure and medical equipment to bridge the gap of resource-limitation in intensive care units (ICUs) across Pakistan. An initial step in creating a plan toward strengthening Pakistan’s baseline critical care capacity was to carry out a needs-assessment within the country to assess gaps and devise strategies for improving the quality of critical care facilities. Methods To assess the baseline critical care capacity of Pakistan, we conducted a series of cross-sectional surveys of hospitals providing COVID-19 care across the country. These hospitals were pre-identified by the Health Services Academy (HSA), Pakistan. Surveys were administered via telephonic and on-site interviews and based on a unique checklist for assessing critical care units which was created from the Partners in Health 4S Framework, which is: Space, Staff, Stuff, and Systems. These components were scored, weighted equally, and then ranked into quartiles. Results A total of 106 hospitals were surveyed, with the majority being in the public sector (71.7%) and in the metropolitan setting (56.6%). We found infrastructure, staffing, and systems lacking as only 19.8% of hospitals had negative pressure rooms and 44.4% had quarantine facilities for staff. Merely 36.8% of hospitals employed accredited intensivists and 54.8% of hospitals maintained an ideal nurse-to-patient ratio. 31.1% of hospitals did not have a staffing model, while 37.7% of hospitals did not have surge policies. On Chi-square analysis, statistically significant differences ( p   〈  0.05) were noted between public and private sectors along with metropolitan versus rural settings in various elements. Almost all ranks showed significant disparity between public–private and metropolitan–rural settings, with private and metropolitan hospitals having a greater proportion in the 1st rank, while public and rural hospitals had a greater proportion in the lower ranks. Conclusion Pakistan has an underdeveloped critical care network with significant inequity between public–private and metropolitan–rural strata. We hope for future resource allocation and capacity development projects for critical care in order to reduce these disparities.
    Type of Medium: Online Resource
    ISSN: 1364-8535
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2051256-9
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  • 4
    Online Resource
    Online Resource
    Army Medical College ; 2023
    In:  Pakistan Armed Forces Medical Journal Vol. 73, No. 2 ( 2023-04-17), p. 353-56
    In: Pakistan Armed Forces Medical Journal, Army Medical College, Vol. 73, No. 2 ( 2023-04-17), p. 353-56
    Abstract: Objective: To compare adjusted calcium levels with ionised Calcium in chronic renal failure patients with hypoalbuminemia for the correct assessment of their Calcium status. Study Design: Cross-sectional study. Place and Duration of Study: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from Mar 2020 to Jan 2021. Methodology: A total of 304 individuals aged 18 to 90 years, of either gender were included in the study. Participants were differentiated into stages of Chronic renal failure based on the estimated glomerular filtration rate calculated through the Chronic Kidney Disease Epidemiology Collaboration equation. Serum total Calcium, urea and creatinine were analysed on ADVIA 1800R Clinical Chemistry Auto analyser. In addition, ionised Calcium was analysed on Cobas b221 blood gas and electrolyte analyser. Results: Mean age of the study participants was 56.3±16.03 years. 130(42.5%) individuals had stage-5 while 102(33.3%) had stage 4 chronic kidney disease. Based on ionised Calcium concentration, 37.3% of participants had hypocalcaemia, 57.2% had normocalcaemia, and 4.9% had hypercalcaemia. 57.5% had albumin concentration between 20-29g/L. Cohen’s Kappa statistical analysis showed adjusted Calcium to be a poor predictor of the correct Calcium status of the patients with hypoalbuminemia. Conclusion: Adjusted Calcium, using the Modified Payne formula, overestimates Calcium status in patients of chronic renal failure with hypoalbuminemia when compared with total unadjusted Calcium levels hence misclassifying true hypocalcaemic patients as normocalcaemic.Keywords: Adjusted calcium, Chronic renal failure, Estimated glomerular filtration rate, Hypoalbuminemia, Ionised calcium.
    Type of Medium: Online Resource
    ISSN: 2411-8842 , 0030-9648
    Language: Unknown
    Publisher: Army Medical College
    Publication Date: 2023
    detail.hit.zdb_id: 2923742-7
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  • 5
    In: Nature Genetics, Springer Science and Business Media LLC, Vol. 55, No. 3 ( 2023-03), p. 369-376
    Abstract: Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of the protein-coding regions of the genome identified a causal role for ten genes and a concentration of rare variant signals in evolutionarily constrained genes 1 . This recent study—and most other large-scale human genetics studies—was mainly composed of individuals of European (EUR) ancestry, and the generalizability of the findings in non-EUR populations remains unclear. To address this gap, we designed a custom sequencing panel of 161 genes selected based on the current knowledge of SCZ genetics and sequenced a new cohort of 11,580 SCZ cases and 10,555 controls of diverse ancestries. Replicating earlier work, we found that cases carried a significantly higher burden of rare protein-truncating variants (PTVs) among evolutionarily constrained genes (odds ratio = 1.48; P  = 5.4 × 10 −6 ). In meta-analyses with existing datasets totaling up to 35,828 cases and 107,877 controls, this excess burden was largely consistent across five ancestral populations. Two genes ( SRRM2 and AKAP11 ) were newly implicated as SCZ risk genes, and one gene ( PCLO ) was identified as shared by individuals with SCZ and those with autism. Overall, our results lend robust support to the rare allelic spectrum of the genetic architecture of SCZ being conserved across diverse human populations.
    Type of Medium: Online Resource
    ISSN: 1061-4036 , 1546-1718
    RVK:
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1494946-5
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Army Medical College ; 2023
    In:  Pakistan Armed Forces Medical Journal Vol. 73, No. 2 ( 2023-04-18), p. 477-80
    In: Pakistan Armed Forces Medical Journal, Army Medical College, Vol. 73, No. 2 ( 2023-04-18), p. 477-80
    Abstract: Objective: To assess growth hormone (GH) stimulation test efficacy in short stature workup for establishing GH deficiency. Study Design: Cross-sectional survey. Place and Duration of Study: Diagnostic Endocrine Section, Department of Chemical Pathology & Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi Pakistan, from Aug 2020 to Jan 2021. Methodology: The study was conducted on 129 individuals aged 2-16 years. History, axiological data and biochemical parameters were assessed to establish GH deficiency for short stature workup. Results: Out of 129 individuals, 76(59%) boys and 53(41%) girls reported GH stimulation tests. 81(62.3%) children were in 〈 3rd percentile, 29(22.3%) in 〈 5th percentile, 9(6.9%) in 〈 10th percentile and 5(3.8%) in 〈 25th percentile. Among the group with bone age difference 〉 2 years, 34(82.9%) fell in 〈 3rd percentile. GH Stimulation test post-Levo Dopa was performed in 102(78.46%) patients. 49(37.4%) patients responded inadequately to the GH stimulation test. The adequate response to the GH Stimulation test improved as the percentile declined from the 50th to the 3rd percentile. Conclusion: GH stimulation test results can only partially rely upon though their importance remains in combination with other short-stature workup parameters for ruling out growth hormone deficiency. 
    Type of Medium: Online Resource
    ISSN: 2411-8842 , 0030-9648
    Language: Unknown
    Publisher: Army Medical College
    Publication Date: 2023
    detail.hit.zdb_id: 2923742-7
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  • 7
    Online Resource
    Online Resource
    Lahore Medical and Dental College ; 2021
    In:  Pakistan Journal of Medical and Health Sciences Vol. 15, No. 8 ( 2021-08-25), p. 1899-1902
    In: Pakistan Journal of Medical and Health Sciences, Lahore Medical and Dental College, Vol. 15, No. 8 ( 2021-08-25), p. 1899-1902
    Abstract: Aim: To evaluate the radiographical success of Regenerative endodontics procedure in permanent immature teeth with necrotic pulp. Methods: This Descriptive case series was conducted at the Department of Operative Dentistry, de’Montmorency College of Dentistry/ Punjab Dental Hospital, Lahore from November 2015 to November 2016. A total of 30 cases were included using non-probability consecutive sampling. Patients of both genders with age range from 9 to 14 years were considered. Performance of procedure and evaluation of success was done in terms of root development on periapical radiographs. . Data was entered and analysed with IBM SPSS 20. Level of significance was kept at p-value ≤ 0.05 Results: Out of 30 patients, 13 were females and 17 were males. Mean age of patients included in this study was 11.5±1.737. Follow up at 12 months showed 90% success, with 27 cases showed root development on periapical radiograph. There was no significant relation of success with age and gender of patient with p- value greater than 0.05. Conclusion: It is concluded from current study that Regenerative Endodontics procedure in permanent immature teeth is encouraging and can be recommended for the treatment of permanent immature teeth with necrotic pulp. Further research studies are required for evaluation of root development in regenerative endodontics procedure. Key words: Regenerative Endodontics, Permanent Immature teeth, Root development
    Type of Medium: Online Resource
    URL: Issue
    Language: Unknown
    Publisher: Lahore Medical and Dental College
    Publication Date: 2021
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  • 8
    Online Resource
    Online Resource
    Lahore Medical and Dental College ; 2021
    In:  Pakistan Journal of Medical and Health Sciences Vol. 15, No. 8 ( 2021-08-30), p. 2448-2450
    In: Pakistan Journal of Medical and Health Sciences, Lahore Medical and Dental College, Vol. 15, No. 8 ( 2021-08-30), p. 2448-2450
    Abstract: Objective: The aim of the study is to correlate the AST to platelets ratio (APRI) with different stages of liver fibrosis measured by the fibroscan. Methods: The study included 40 patients. The study was conducted in outpatient clinic of Lahore General Hospital. The study duration was from November-2020 to January-2021. Their fibroscan data was collected from hepatic clinic of general hospital OPD and their AST and Platelets values were obtained retrogradely from the PACS system of hospital. Correlation between the APRI and fibroscan values was done by linear Pearson correlation test. Results: APRI values showed moderately positive correlation with increased kpa values and different stages of fibrosis (r=0.55). Similarly, the correlation coefficient of AST also shown to be moderately positive correlated with kpa values and stages of fibrosis however this correlation was slightly weak as compared to APRI values (r=0.49). The correlation coefficient (r) for platelets showed moderately negative correlation with liver fibrosis stages (r=-0.43). Conclusions: APRI levels increased as the degree of fibrosis and inflammation increased in patients suffering from chronic hep B and hep C. So, our data showed the clinical significance of APRI levels in diagnosing extent of liver fibrosis and cirrhosis. Keywords: AST, Platelets, APRI, fibroscan, chronic hepatitis
    Type of Medium: Online Resource
    URL: Issue
    Language: Unknown
    Publisher: Lahore Medical and Dental College
    Publication Date: 2021
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  • 9
    In: Reaction Kinetics, Mechanisms and Catalysis, Springer Science and Business Media LLC, Vol. 135, No. 1 ( 2022-02), p. 499-510
    Type of Medium: Online Resource
    ISSN: 1878-5190 , 1878-5204
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2537214-2
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  • 10
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2012
    In:  Australasian Physical & Engineering Sciences in Medicine Vol. 35, No. 3 ( 2012-9), p. 297-300
    In: Australasian Physical & Engineering Sciences in Medicine, Springer Science and Business Media LLC, Vol. 35, No. 3 ( 2012-9), p. 297-300
    Type of Medium: Online Resource
    ISSN: 0158-9938 , 1879-5447
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2012
    detail.hit.zdb_id: 2003728-4
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