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  • 1
    Online Resource
    Online Resource
    Dowex 50W in Aqueous Medium: Highly Efficient Biginelli Condensation Procedure for the Synthesis of 4-Aryl-3,4-dihydropyrimidones
    The Japan Institute of Heterocyclic Chemistry ; 2007
    In:  HETEROCYCLES Vol. 71, No. 1 ( 2007), p. 181-
    Details
    In: HETEROCYCLES, The Japan Institute of Heterocyclic Chemistry, Vol. 71, No. 1 ( 2007), p. 181-
    Type of Medium: Online Resource
    ISSN: 0385-5414
    URL: Article
    DOI: 10.3987/COM-06-10924
    RVK:
    VA 4550
    Language: English
    Publisher: The Japan Institute of Heterocyclic Chemistry
    Publication Date: 2007
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  • 2
    Online Resource
    Online Resource
    A Green Method for the Synthesis of 2-Arylbenzothiazoles
    The Japan Institute of Heterocyclic Chemistry ; 2007
    In:  HETEROCYCLES Vol. 71, No. 8 ( 2007), p. 1837-
    Details
    In: HETEROCYCLES, The Japan Institute of Heterocyclic Chemistry, Vol. 71, No. 8 ( 2007), p. 1837-
    Type of Medium: Online Resource
    ISSN: 0385-5414
    URL: Article
    DOI: 10.3987/COM-07-11079
    RVK:
    VA 4550
    Language: English
    Publisher: The Japan Institute of Heterocyclic Chemistry
    Publication Date: 2007
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  • 3
    Online Resource
    Online Resource
    Extra-Gonadal Teratomas in Atypical Sites in Neonates and Children – Our Experience and Review of the Literature
    Science Repository OU ; 2021
    In:  Clinical Oncology and Research
    Details
    In: Clinical Oncology and Research, Science Repository OU
    Abstract: Background: Extra-gonadal teratomas are rare tumors in Pediatric surgical practice. We studied the teratomas of atypical sites attended in our tertiary care center. Aim: Aim of the study was to find out the incidence of pediatric teratomas in atypical sites, clinical presentation and histological variation. Material and Methods: Over 15 years (January 2005 to December 2020), 29 cases of pediatric teratomas in atypical sites were studied. These sites included neck (number-one), retroperitoneum (number-fourteen), adrenal gland (number-two), renal (number-two), gastric(number-three), pancreas (number-one), pulmonary (number-one), floor of the mouth(number-one), oral (number-two), abdominal wall (numberone) and the mesentery (number-one). Patients were treated in the Department of Pediatric Surgery and specimens were reviewed in the Department of Pathology. Age, sex, clinical presentation, investigations (all patients had complete blood examination and alpha-fetoprotein) and imaging (USG of the local part and CECT as guided by the organ of involvement). Results: 29 pediatric teratomas in uncommon sites were reviewed. Out of 14 cases of retroperitoneal teratoma, three were immature. Cervical teratoma in a neonate was mature. Three cases of gastric teratomas were reported as mature. Two cases of adrenal teratomas also showed the histological features of mature teratoma. Renal teratomas (two) were benign. One each of pulmonary teratoma, pancreas and floor of the mouth were reported as mature. Two patients presented with oral teratoma were reported as mature teratomas. One patient had teratoma arising from the abdominal wall and was resected completely (mature teratoma). Teratoma arising from the mesentery also underwent complete resection. Conclusion: A small percentage of Pediatric teratomas occur in atypical sites. In our series, retroperitoneal tumors were predominant. Early surgical excision is the treatment of choice. Malignant change is known to occur in Pediatric teratoma and the patients need long term follow-up.
    Type of Medium: Online Resource
    ISSN: 2613-4942 , 2613-4942
    URL: Journal
    URL: Article
    DOI: 10.31487/j.COR
    DOI: 10.31487/j.COR.2021.02.03
    Language: Unknown
    Publisher: Science Repository OU
    Publication Date: 2021
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  • 4
    Online Resource
    Online Resource
    Unusual renal tumor in an infant
    IP Innovative Publication Pvt Ltd ; 2021
    In:  Indian Journal of Pathology and Oncology Vol. 8, No. 3 ( 2021-8-28), p. 400-402
    Details
    In: Indian Journal of Pathology and Oncology, IP Innovative Publication Pvt Ltd, Vol. 8, No. 3 ( 2021-8-28), p. 400-402
    Abstract: : Two-month-old female presented with left loin swelling and pain. The swelling was 8cmx6cm and it was ballotable in nature. It was gradually increasing in size. : To find out the incidence of this rare, high index of suspicion, investigations including cytopathology and histopathology, early diagnosis and management. : The informed consent from the parents of the patient was taken. The study was carried out in a tertiary care hospital in Kolkata. On CT a heterogenous renal mass was detected. Fine Needle Aspiration cytology from the mass showed mature neural elements, squamous epithelium, mature fat cells a few atypical oval to spindle shaped cells. Cytologically diagnosed as mature teratoma. The tumor was excised. Histopathological examination revealed the diagnosis of immature teratoma. : Immature teratoma is one of the rare causes of Pediatric Kidney Tumor. Renal teratoma is an extremely uncommon tumor in infancy. But it is one of the differential diagnoses of renal mass in infants. Diagnosis may be suspected from radiological investigation and confirmed by histopathological examination. A good prognosis can be expected after proper management.
    Type of Medium: Online Resource
    ISSN: 2394-6784 , 2394-6792
    URL: Journal
    URL: Article
    DOI: 10.18231/ijpo
    DOI: 10.18231/j.ijpo.2021.079
    Language: Unknown
    Publisher: IP Innovative Publication Pvt Ltd
    Publication Date: 2021
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  • 5
    Online Resource
    Online Resource
    Immunohistochemistry-based comparative study in detection of Hirschsprung’s disease in infants in a Tertiary Care Center
    Georg Thieme Verlag KG ; 2017
    In:  Journal of Laboratory Physicians Vol. 9, No. 02 ( 2017-04), p. 076-080
    Details
    In: Journal of Laboratory Physicians, Georg Thieme Verlag KG, Vol. 9, No. 02 ( 2017-04), p. 076-080
    Abstract: BACKGROUND: Hirschsprung’s disease (HD) is the major cause of pediatric intestinal obstruction with a complex pattern of inheritance. The absence of ganglion cells along with an analysis of hypertrophy and hyperplasia of nerves in the nerve plexus of submucosa and muscularis mucosae is regarded as a potential hallmark for its diagnosis. AIMS AND OBJECTIVES: This study was undertaken to ascertain the (1) clinical profile, (2) mode of presentation, and (3) to compare the role of calretinin immunostaining with acetylcholinesterase in the diagnosis of HD. MATERIALS AND METHODS: This prospective and observational study was conducted in the Department of Pathology, IPGME & R from June 2014 to May 2015. One hundred and four patients clinically and radiologically diagnosed with HD underwent surgery were included in the study. The data of every patient including age, sex, and presenting symptoms were recorded. Eventually, histopathological, calretinin, and acetylcholinesterase immunohistochemical examination were done. RESULTS: Total numbers of cases studied were 104, which aged between 0 days and 365 days. Male preponderance (76.92%) was noted. The overall sensitivity, specificity, positive, and negative predictive value of acetylcholinesterase were 100%, 86.44%, 84.91%, and 100%, respectively. The concordance of detection of ganglion cells and nerve fibers, and thereby diagnosis of Hirschsprung’s and non-HD using calretinin and the gold standard was statistically in strong agreement (κ = 0.749, 95% confidence interval: 0.635–0.863). CONCLUSIONS: Calretinin stands out as the single and indispensable tool that differentiates HD from other mimickers.
    Type of Medium: Online Resource
    ISSN: 0974-2727 , 0974-7826
    URL: Article
    DOI: 10.4103/0974-2727.199623
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2017
    detail.hit.zdb_id: 2461120-7
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  • 6
    Online Resource
    Online Resource
    Spectrum of pediatric kidney tumours with special references to WT1 immunostain at a tertiary care hospital
    Medknow ; 2022
    In:  Journal of Cancer Research and Therapeutics Vol. 18, No. 1 ( 2022), p. 209-213
    Details
    In: Journal of Cancer Research and Therapeutics, Medknow, Vol. 18, No. 1 ( 2022), p. 209-213
    Abstract: Pediatric renal tumours are the second most common solid tumours in children. The most common in this group is Wilms tumour with mesoblastic nephroma being the 2 nd most common tumour in children, younger than 3 months. Aims and Objectives: The present study was conducted to study the epidemiological occurrence of pediatric renal tumours at a tertiary care hospital and to study the diagnostic efficacy of WT1 immunostaining in distinguishing Wilms tumour from other types of renal tumours. Materials and Methods: It was a single institution-based prospective and observational study conducted for 2 years (from October 2013 to September 2015) in the department of pathology in our hospital. A total of 50 cases were enrolled in this study all were below 15 years of age. Results: Nephroblastoma or Wilms tumour was found to be the most common type, occurring in 66% cases. Fourteen out of 33 cases of Wilms tumour showed triphasic components (blastemal, epithelial, and stromal) with Blastemal type Wilms being the second most common (11 cases). WT1 immunostaining was positive in 93.9% cases of nephroblastoma. The highest amount of nuclear positivity noted in blastemal cells followed by epithelial cells. Rhabdomyoblastic differentiation and regressive variant showed nonspecific cytoplasmic staining. Cystic partially differentiated nephroblastoma and diffuse anaplasia type Wilms tumour showed nuclear staining in blastemal cells. Conclusion: The expression of WT1 immunostain was found to be diagnostically significant in differentiating Wilms tumour from other renal tumours.
    Type of Medium: Online Resource
    ISSN: 0973-1482
    URL: Article
    DOI: 10.4103/jcrt.JCRT_436_19
    Language: English
    Publisher: Medknow
    Publication Date: 2022
    detail.hit.zdb_id: 2187633-2
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  • 7
    Online Resource
    Online Resource
    An Epidemiological Review of Sacrococcygeal Teratoma over Five Years in a Tertiary Care Hospital
    Georg Thieme Verlag KG ; 2018
    In:  Indian Journal of Medical and Paediatric Oncology Vol. 39, No. 01 ( 2018-01), p. 4-7
    Details
    In: Indian Journal of Medical and Paediatric Oncology, Georg Thieme Verlag KG, Vol. 39, No. 01 ( 2018-01), p. 4-7
    Abstract: Background: Teratoma refers to neoplasm containing at least two germ cell layers derivatives foreign to the site of origin. Sacrococcygeal teratoma is most common congenital tumor commonly present as an exophytic mass of varying size at coccyx. Aims and Objectives: (1) The aim is to find age, sex, and clinical presentation of cases of sacrococcygeal teratoma. (2) Application of American Academy of Pediatrics' surgical section classification and histological grading in all cases. Materials and Methods: A retrospective, observational study was conducted in the Department of Pathology in collaboration with the Department of Pediatric Surgery from February 2009 to January 2014. A total 13 cases of sacrococcygeal teratoma were included in the present study. The records of these patients were reviewed, and clinical profiles were noted. An average 12 slides were examined in each case to evaluate histological type and grades. Results: A retrospective study was conducted including thirteen cases of histologically confirmed sacrococcygeal teratoma over 5 years period. Male to female ratio was 1:2. As per as age distribution is concerned, 3 neonates (23%) presented with sacrococcygeal mass. Associated congenital malformation was seen in 2 cases (15.4%). According to the American Academy of Pediatrics (Altman's) classification, 23% of cases were Type I, 31% of cases patients Type II, 31% of cases Type III and 15% were for Type IV. The significant presacral component was noted in all malignant tumors. Conclusion: Two clinical patterns were observed in sacrococcygeal teratoma related to the age of presentation. As sacrococcygeal teratoma has potential to become malignant, meticulous search for the malignant component is required for histopathological categorization.
    Type of Medium: Online Resource
    ISSN: 0971-5851 , 0975-2129
    URL: Article
    DOI: 10.4103/ijmpo.ijmpo_239_14
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2018
    detail.hit.zdb_id: 2181724-8
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  • 8
    Online Resource
    Online Resource
    Leydig cell tumor of testis in a child: An uncommon presentation
    Medknow ; 2017
    In:  Journal of Indian Association of Pediatric Surgeons Vol. 22, No. 3 ( 2017), p. 181-
    Details
    In: Journal of Indian Association of Pediatric Surgeons, Medknow, Vol. 22, No. 3 ( 2017), p. 181-
    Type of Medium: Online Resource
    ISSN: 0971-9261
    URL: Article
    DOI: 10.4103/jiaps.JIAPS_4_17
    Language: English
    Publisher: Medknow
    Publication Date: 2017
    detail.hit.zdb_id: 2164528-0
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  • 9
    Online Resource
    Online Resource
    Spectrum of meningioma with special reference to prognostic utility of ER,PR and Ki67 expression
    Georg Thieme Verlag KG ; 2017
    In:  Journal of Laboratory Physicians Vol. 9, No. 04 ( 2017-10), p. 308-313
    Details
    In: Journal of Laboratory Physicians, Georg Thieme Verlag KG, Vol. 9, No. 04 ( 2017-10), p. 308-313
    Abstract: BACKGROUND: Meningiomas are the most common primary central nervous system neoplasms originating from the arachnoid cap cells and constitute between 13% and 26% of all intracranial tumors. AIMS AND OBJECTIVES: The aim of the study was to analyze the age-, sex-, and site-wise distribution of different histological patterns of meningiomas seen in our center and to assess the status of estrogen receptor (ER), progesterone receptor (PR), and proliferation marker Ki-67 in various grades of meningioma. MATERIALS AND METHODS: A prospective study was done in 90 cases. Patients presented with symptoms of headache and seizure and underwent subsequent excision surgery at Neurosurgery Department were taken. We have studied histological typing and grading of the tumors, and immunohistochemical staining was done for ER, PR, and Ki-67. STATISTICAL ANALYSIS: Two-group comparison was done using Mann–Whitney U-test and Fisher’s exact test. Comparison of Ki-67 expression between Grade 1 and Grade 2 meningiomas was determined using Mann–Whitney U-test. Comparison of ER and PR status between different histological grades was done by Fisher’s exact test. Two-tailed P 〈 0.001 was considered statistically significant. RESULTS: According to histological type, meningothelial meningioma is most common (38.8%) followed by transitional (22.2%). PR positivity is seen in 96.34% of Grade 1 tumors, and all Grade 2 tumors were PR negative (Fisher’s exact test P 〈 0.001). About 3.66% of Grade 1 and all Grade 2 tumors were positive for ER (Fisher’s exact test two-tailed P 〈 0.001). Mean Ki-67 labeling index (LI) was 2.57 ± 1.674 among Grade I tumors, 7.11 ± 1.084 in Grade II meningiomas. CONCLUSIONS: Most of Grade 1 meningiomas show PRs positivity and lack of ERs positivity. Meningiomas with higher proliferation index and negative PR are very likely to be Grade II or Grade III. Evaluation of ER, PR status, and Ki-67 labeling index (LI) with histological evaluation helps us in providing information about the biologic behavior of meningiomas.
    Type of Medium: Online Resource
    ISSN: 0974-2727 , 0974-7826
    URL: Article
    DOI: 10.4103/JLP.JLP_158_16
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2017
    detail.hit.zdb_id: 2461120-7
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  • 10
    Online Resource
    Online Resource
    Spectrum of Pediatric gastrointestinal tumors with special reference to clinico-pathological findings.
    IOSR Journals ; 2016
    In:  IOSR Journal of Dental and Medical Sciences Vol. 15, No. 09 ( 2016-09), p. 49-53
    Details
    In: IOSR Journal of Dental and Medical Sciences, IOSR Journals, Vol. 15, No. 09 ( 2016-09), p. 49-53
    Type of Medium: Online Resource
    ISSN: 2279-0861 , 2279-0853
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.9790/0853-150912
    DOI: 10.9790/0853
    DOI: 10.9790/0853-1509124953
    Language: Unknown
    Publisher: IOSR Journals
    Publication Date: 2016
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