In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 7 ( 2021-7-6), p. e1009688-
Abstract:
There is an urgent need for effective therapeutic interventions against SARS-CoV-2, including new variants that continue to arise. Neutralizing monoclonal antibodies have shown promise in clinical studies. We investigated the therapeutic efficacy of a combination of two potent monoclonal antibodies, C135-LS and C144-LS that carry half-life extension mutations, in the rhesus macaque model of COVID-19. Twelve young adult macaques (three groups of four animals) were inoculated intranasally and intra-tracheally with a high dose of SARS-CoV-2 and 24 hours later, treated intravenously with a high (40 mg/kg) or low (12 mg/kg) dose of the C135-LS and C144-LS antibody combination, or a control monoclonal antibody. Animals were monitored for 7 days. Compared to the control animals, animals treated with either dose of the anti-SARS-CoV-2 antibodies showed similarly improved clinical scores, lower levels of virus replication in upper and lower respiratory tract, and significantly reduced interstitial pneumonia, as measured by comprehensive lung histology. In conclusion, this study provides proof-of-concept in support of further clinical development of these monoclonal antibodies against COVID-19 during early infection.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009688
DOI:
10.1371/journal.ppat.1009688.g001
DOI:
10.1371/journal.ppat.1009688.g002
DOI:
10.1371/journal.ppat.1009688.g003
DOI:
10.1371/journal.ppat.1009688.g004
DOI:
10.1371/journal.ppat.1009688.g005
DOI:
10.1371/journal.ppat.1009688.g006
DOI:
10.1371/journal.ppat.1009688.g007
DOI:
10.1371/journal.ppat.1009688.s001
DOI:
10.1371/journal.ppat.1009688.s002
DOI:
10.1371/journal.ppat.1009688.s003
DOI:
10.1371/journal.ppat.1009688.s004
DOI:
10.1371/journal.ppat.1009688.s005
DOI:
10.1371/journal.ppat.1009688.s006
DOI:
10.1371/journal.ppat.1009688.s007
DOI:
10.1371/journal.ppat.1009688.s008
DOI:
10.1371/journal.ppat.1009688.s009
DOI:
10.1371/journal.ppat.1009688.s010
DOI:
10.1371/journal.ppat.1009688.s011
DOI:
10.1371/journal.ppat.1009688.s012
DOI:
10.1371/journal.ppat.1009688.s013
DOI:
10.1371/journal.ppat.1009688.s014
DOI:
10.1371/journal.ppat.1009688.s015
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2205412-1
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