In:
American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 62, No. 5 ( 2001-05-01), p. 799-804
Kurzfassung:
Objective —To assess blood oxygen binding in calves
with diarrhea. Animals —22 dairy and 26 double-muscled calves
with diarrhea, 31 healthy dairy calves and 37 healthy double-muscled calves. Procedure —Severity of disease, including the ability
of affected calves to stand, was evaluated. Hydration and signs of depression were scored. Venous and
arterial blood samples were collected, and 2,3-diphosphoglycerate, ATP, chloride, inorganic phosphate, lactate,
pyruvate, total protein, albumin, and hemoglobin concentrations, and Hct, pH, Pco 2 , and Po 2 were
determined. Oxygen equilibrium curves (OEC) were constructed under standard conditions, and oxygen
extraction ratios were calculated. Results —Recumbent calves of both breed-types
were more dehydrated and had more severe signs of depression than ambulatory affected calves. In both
breed-types, hemoglobin oxygen affinity was increased in calves with diarrhea, compared with
healthy calves, as indicated by a decrease in standard partial oxygen pressure (P50). Diarrhea induced
hypocapnia and hypothermia in the most severely affected calves, which counteracted the acidosisinduced
right shift in arterial and venous OEC. Arterial and venous P50 were significantly less in doublemuscled
calves with diarrhea than healthy calves, whereas P50 for affected dairy calves were similar to
those of healthy calves. Except in the most severely affected dairy calves, oxygen extraction ratio was significantly
less in calves with diarrhea, compared with healthy calves. Conclusions and Clinical Relevance —Release of
oxygen from blood may be impaired in calves with diarrhea, depending on the effect of the disease on
certain blood biochemical variables. ( Am J Vet Res 2001;62:799–804).
Materialart:
Online-Ressource
ISSN:
0002-9645
DOI:
10.2460/ajvr.2001.62.799
Sprache:
Unbekannt
Verlag:
American Veterinary Medical Association (AVMA)
Publikationsdatum:
2001
ZDB Id:
2056942-7
SSG:
22
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