In:
Clinical Endocrinology, Wiley, Vol. 89, No. 5 ( 2018-11), p. 667-676
Abstract:
Abnormal liver function tests ( LFT s) are frequent in Turner syndrome ( TS ). The causes and clinical significance are unclear. Aims To investigate the prevalence of elevated LFT s in adult TS ; secondly, to analyse the associations between elevated LFT s, TS ‐karyotypes and TS ‐related conditions; and thirdly, to evaluate liver stiffness and histological assessment. Methods A total of 125 TS women were retrospectively studied. Karyotypes, clinical and biochemical details and aortic measurements were recorded. Fibroscan and liver biopsy results were noted. Results Elevated LFT s were found in 49.6%: gamma‐glutamyltransferase ( GGT ) in 88.7%, ALK in 45.2%, ALT in 40.3% and AST in 29%. A FIB ‐4 index 〉 1.3 was found in 11.8%. Women with isochromosome of the X long arm, iso[X](q), had a higher prevalence of elevated LFT s. A lower prevalence of abnormal GGT was found in patients with 45,X/46, XX , 45,X/47, XXX or 45,X/46, XX /47, XXX . Subjects with raised GGT were older, shorter and more likely to have higher triglyceride levels. There was no association with HRT duration after adjusting for age. Among patients with elevated aminotransferases, no differences were noted, except for higher HDL ‐cholesterol levels. The sinuses and ascending aorta diameter were greater in the elevated LFT s group. Fibroscan was suggestive of significant liver fibrosis in 38.1%. Among 11 biopsies, liver architectural changes were reported in 45.4%, including two with cirrhosis. Conclusions Elevated LFT s in TS are common and important to detect given the possible progression towards severe liver disease. An association between raised LFT s and karyotype iso[X]q was demonstrated. We have also shown a new association between abnormal LFT s and aortic dilatation.
Type of Medium:
Online Resource
ISSN:
0300-0664
,
1365-2265
DOI:
10.1111/cen.2018.89.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2004597-9
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